TOPIC 1 0.01524 TOPIC 2 0.01471 mice 0.35496 genotyp 0.20283 mous 0.12467 polymorph 0.19070 transgen 0.08784 allel 0.14506 develop 0.03947 associ 0.05069 model 0.03775 frequenc 0.04562 wild-typ 0.02355 gene 0.03342 knockout 0.02177 genet 0.01698 murin 0.01884 popul 0.01685 anim 0.01674 suscept 0.01528 c57bl 0.01498 homozyg 0.01476 balb 0.00989 distribut 0.01242 gener 0.00987 control 0.01240 exhibit 0.00959 homozygot 0.01040 vivo 0.00921 influenc 0.01015 lack 0.00770 healthi 0.00990 defici 0.00707 carrier 0.00955 cre 0.00703 signific 0.00894 heterozyg 0.00697 individu 0.00886 embryon 0.00683 risk 0.00850 null 0.00675 differ 0.00776 Mice 0.26707 Genotype 0.13075 Animals 0.20472 Polymorphism, Genetic 0.12173 Mice, Inbred C57BL 0.06831 Humans 0.10770 Mice, Transgenic 0.06536 Alleles 0.05765 Mice, Knockout 0.06523 Middle Aged 0.04965 Disease Models, Animal 0.03695 Gene Frequency 0.04714 Mice, Inbred BALB C 0.01878 Adult 0.04599 Mice, Mutant Strains 0.01456 Genetic Predisposition to Disease 0.04235 Transgenes 0.01150 Aged 0.03091 Mice, Inbred Strains 0.00933 Polymerase Chain Reaction 0.02796 Immunohistochemistry 0.00576 Case-Control Studies 0.02655 Gene Expression 0.00537 Polymorphism, Single Nucleotide 0.01854 Mice, Inbred C3H 0.00476 Polymorphism, Restriction Fragment Length 0.01543 Gene Targeting 0.00472 Variation (Genetics) 0.00980 Time Factors 0.00448 Adolescent 0.00938 Gene Deletion 0.00430 Aged, 80 and over 0.00923 Aging 0.00396 Homozygote 0.00873 Spleen 0.00391 Risk Factors 0.00859 Models, Animal 0.00369 Heterozygote 0.00817 Integrases 0.00364 Asian Continental Ancestry Group 0.00776 TOPIC 3 0.01400 TOPIC 4 0.01335 apoptosi 0.21336 patient 0.81736 cell 0.08839 clinic 0.03664 apoptot 0.04947 methods 0.02269 bcl-2 0.04720 conclusions 0.01513 induc 0.03971 evalu 0.00836 bax 0.02764 aim 0.00795 caspas 0.02696 objective 0.00657 death 0.02177 consecut 0.00608 caspase-3 0.01961 frequent 0.00601 activ 0.01550 perform 0.00578 trail 0.01239 patients 0.00524 proapoptot 0.01057 cohort 0.00507 pathwai 0.01046 diagnos 0.00500 inhibit 0.00969 seven 0.00480 induct 0.00904 suffer 0.00349 caspase-8 0.00878 accord 0.00342 anti-apoptot 0.00867 retrospect 0.00327 cleavag 0.00837 underw 0.00306 inhibitor 0.00833 occurr 0.00292 antiapoptot 0.00831 subgroup 0.00263 Apoptosis 0.19454 Humans 0.20626 Humans 0.07436 Adult 0.16795 Caspases 0.05697 Middle Aged 0.16644 Proto-Oncogene Proteins c-bcl-2 0.05149 Aged 0.10873 Cell Line, Tumor 0.02991 Adolescent 0.05098 Animals 0.02229 Aged, 80 and over 0.03390 bcl-2-Associated X Protein 0.01970 Child 0.02270 Cell Survival 0.01894 Case-Control Studies 0.02196 Mitochondria 0.01887 Retrospective Studies 0.01944 Apoptosis Regulatory Proteins 0.01690 Child, Preschool 0.01591 Membrane Glycoproteins 0.01632 Prospective Studies 0.01101 Enzyme Activation 0.01478 Treatment Outcome 0.00773 In Situ Nick-End Labeling 0.01378 Cohort Studies 0.00691 Antineoplastic Agents 0.01313 Severity of Illness Index 0.00666 Tumor Necrosis Factor-alpha 0.01164 Follow-Up Studies 0.00529 Blotting, Western 0.01134 Infant 0.00412 Cytochromes c 0.01056 Prognosis 0.00350 Antigens, CD95 0.01040 Sensitivity and Specificity 0.00278 Carrier Proteins 0.01018 Risk Factors 0.00251 Mice 0.00955 Disease Progression 0.00205 TOPIC 5 0.01335 TOPIC 6 0.01296 health 0.06869 ethic 0.04286 care 0.05610 research 0.03873 nurs 0.02705 issu 0.02256 servic 0.02306 public 0.01408 educ 0.02100 medic 0.01312 commun 0.01892 health 0.01282 practic 0.01743 moral 0.01253 medic 0.01494 consent 0.01227 profession 0.01339 practic 0.01184 physician 0.01337 concern 0.01124 program 0.01332 polici 0.00966 student 0.01307 conflict 0.00863 survei 0.01295 right 0.00836 particip 0.01260 articl 0.00824 manag 0.01218 accept 0.00815 need 0.01157 law 0.00760 provid 0.01026 social 0.00760 knowledg 0.00931 debat 0.00744 home 0.00901 question 0.00743 interview 0.00880 paper 0.00734 Humans 0.14800 Humans 0.14909 Adult 0.03213 United States 0.03724 United States 0.03180 Informed Consent 0.01675 Questionnaires 0.02463 Ethics, Medical 0.01059 Middle Aged 0.02036 Personal Autonomy 0.00955 Aged 0.01902 Decision Making 0.00929 Attitude of Health Personnel 0.01116 Ethics, Research 0.00841 Adolescent 0.01004 Great Britain 0.00776 Attitude to Health 0.00984 Human Experimentation 0.00668 Great Britain 0.00921 Public Policy 0.00643 Nurse's Role 0.00886 Morals 0.00608 Health Knowledge, Attitudes, Practice 0.00858 Biomedical Research 0.00600 Patient Education 0.00784 Research Subjects 0.00595 Internet 0.00761 Social Justice 0.00589 Health Services Accessibility 0.00581 Confidentiality 0.00583 Communication 0.00576 Social Responsibility 0.00579 Clinical Competence 0.00555 Bioethics 0.00562 Data Collection 0.00551 Physician-Patient Relations 0.00544 Social Support 0.00550 Politics 0.00537 Socioeconomic Factors 0.00522 Conflict of Interest 0.00534 TOPIC 7 0.01256 TOPIC 8 0.01140 mutat 0.53064 promot 0.20474 gene 0.05630 transcript 0.06502 caus 0.02417 element 0.05279 exon 0.02318 gene 0.04997 sequenc 0.02049 site 0.03661 missens 0.01804 bind 0.03384 novel 0.01634 region 0.03285 heterozyg 0.01589 activ 0.02850 identifi 0.01433 regul 0.02410 point 0.01364 assai 0.02099 detect 0.01263 factor 0.01935 codon 0.01155 regulatori 0.01898 delet 0.01140 upstream 0.01844 homozyg 0.01114 sp1 0.01439 carri 0.01013 report 0.01315 analysi 0.00913 box 0.01263 screen 0.00836 sequenc 0.01210 germlin 0.00728 express 0.01122 frequenc 0.00594 contain 0.01084 substitut 0.00548 shift 0.01020 Mutation 0.19204 Promoter Regions (Genetics) 0.13295 Humans 0.11234 Base Sequence 0.05639 DNA Mutational Analysis 0.07231 Molecular Sequence Data 0.04491 Point Mutation 0.03624 Humans 0.04486 Base Sequence 0.03191 Transcription Factors 0.04338 Mutation, Missense 0.02977 Animals 0.03844 Molecular Sequence Data 0.02263 Transcription, Genetic 0.03558 Polymerase Chain Reaction 0.02162 DNA-Binding Proteins 0.03393 Adult 0.02138 Gene Expression Regulation 0.02963 Exons 0.01970 Binding Sites 0.02321 Pedigree 0.01840 Mice 0.02241 Heterozygote 0.01609 Cell Line 0.02043 Phenotype 0.01517 Genes, Reporter 0.01789 Middle Aged 0.01464 Transfection 0.01740 Genotype 0.01239 Trans-Activation (Genetics) 0.01428 Sequence Analysis, DNA 0.01085 Luciferases 0.01428 Amino Acid Substitution 0.01044 Cell Line, Tumor 0.01268 Polymorphism, Single-Stranded Conformational 0.00993 Trans-Activators 0.01124 Child 0.00972 Response Elements 0.01064 Germ-Line Mutation 0.00914 DNA 0.01009 TOPIC 9 0.01138 TOPIC 10 0.01082 domain 0.25205 transcript 0.29694 protein 0.09720 factor 0.12042 motif 0.03980 regul 0.06686 c-termin 0.03904 gene 0.05498 bind 0.03731 repress 0.04479 function 0.03041 express 0.03058 n-termin 0.02920 activ 0.02456 contain 0.02580 promot 0.02136 region 0.02011 protein 0.01678 conserv 0.01863 repressor 0.01583 homolog 0.01640 target 0.01554 truncat 0.01556 function 0.01512 terminu 0.01459 regulatori 0.01464 interact 0.01313 finger 0.01224 tail 0.01293 zinc 0.01113 residu 0.01264 bind 0.01085 transmembran 0.01101 dna-bind 0.00807 full-length 0.00999 act 0.00696 structur 0.00857 transactiv 0.00678 cytoplasm 0.00835 mediat 0.00624 Protein Structure, Tertiary 0.10703 Transcription Factors 0.12153 Amino Acid Sequence 0.09606 Transcription, Genetic 0.10003 Molecular Sequence Data 0.08620 DNA-Binding Proteins 0.08945 Animals 0.05528 Animals 0.04649 Humans 0.05057 Humans 0.03801 Protein Binding 0.03533 Gene Expression Regulation 0.03599 Sequence Homology, Amino Acid 0.02929 Trans-Activators 0.03330 Cell Line 0.02585 Repressor Proteins 0.03004 Recombinant Fusion Proteins 0.01881 Promoter Regions (Genetics) 0.02999 Binding Sites 0.01860 Mice 0.02514 Mice 0.01850 Nuclear Proteins 0.02493 Sequence Alignment 0.01801 Trans-Activation (Genetics) 0.01999 Amino Acid Motifs 0.01792 RNA, Messenger 0.01548 Mutation 0.01707 Molecular Sequence Data 0.01536 Recombinant Proteins 0.01220 Cell Line 0.01424 COS Cells 0.01101 Base Sequence 0.01368 Membrane Proteins 0.01055 Homeodomain Proteins 0.01225 Models, Molecular 0.01021 Reverse Transcriptase Polymerase Chain Reaction 0.01181 Base Sequence 0.01016 Zinc Fingers 0.00840 Transfection 0.00959 Transfection 0.00828 TOPIC 11 0.01074 TOPIC 12 0.00982 patient 0.06986 surviv 0.13808 toxic 0.03399 patient 0.09488 respons 0.02834 prognost 0.06552 dai 0.02169 outcom 0.03810 advanc 0.02057 prognosi 0.03648 chemotherapi 0.02011 clinic 0.02947 cancer 0.01994 factor 0.02942 phase 0.01993 stage 0.02855 median 0.01925 poor 0.02762 surviv 0.01852 signific 0.02754 combin 0.01836 analysi 0.02564 grade 0.01749 independ 0.02339 month 0.01749 multivari 0.01943 docetaxel 0.01622 statu 0.01899 gemcitabin 0.01533 associ 0.01884 cycl 0.01516 predict 0.01766 metastat 0.01463 correl 0.01762 regimen 0.01406 recurr 0.01438 treatment 0.01332 predictor 0.01199 paclitaxel 0.01286 disease-fre 0.00845 Humans 0.08381 Prognosis 0.13183 Antineoplastic Combined Chemotherapy Protocols 0.06399 Humans 0.09307 Middle Aged 0.06167 Middle Aged 0.08495 Aged 0.06127 Aged 0.07610 Adult 0.04837 Adult 0.06695 Treatment Outcome 0.03817 Survival Analysis 0.06206 Drug Administration Schedule 0.02728 Aged, 80 and over 0.04148 Fluorouracil 0.02296 Survival Rate 0.03904 Deoxycytidine 0.02255 Neoplasm Staging 0.03113 Survival Analysis 0.02207 Tumor Markers, Biological 0.02990 Taxoids 0.02076 Disease-Free Survival 0.02403 Cisplatin 0.01947 Multivariate Analysis 0.02124 Antineoplastic Agents 0.01823 Predictive Value of Tests 0.02075 Paclitaxel 0.01598 Retrospective Studies 0.02055 Infusions, Intravenous 0.01514 Treatment Outcome 0.01459 Camptothecin 0.01396 Proportional Hazards Models 0.01366 Antimetabolites, Antineoplastic 0.01340 Immunohistochemistry 0.01325 Aged, 80 and over 0.01313 Neoplasm Recurrence, Local 0.01012 Neutropenia 0.01207 Disease Progression 0.00873 Antineoplastic Agents, Phytogenic 0.01206 Follow-Up Studies 0.00855 TOPIC 13 0.00967 TOPIC 14 0.00931 genom 0.21463 cell 0.22260 sequenc 0.18098 stem 0.10079 conserv 0.05533 progenitor 0.04965 duplic 0.03212 hematopoiet 0.03559 structur 0.01990 differenti 0.02963 complet 0.01951 embryon 0.02325 evolut 0.01811 lineag 0.02030 eukaryot 0.01550 hsc 0.01725 ortholog 0.01456 adult 0.01460 speci 0.01320 marrow 0.01321 compar 0.01212 bone 0.01144 nucleotid 0.01184 erythroid 0.01130 evolutionari 0.01110 cd34+ 0.00939 organ 0.01093 precursor 0.00920 homolog 0.01011 potenti 0.00917 motif 0.00980 cd34 0.00837 comparison 0.00978 marker 0.00767 similar 0.00974 hematopoiesi 0.00759 region 0.00938 msc 0.00746 analysi 0.00937 self-renew 0.00735 Molecular Sequence Data 0.08498 Stem Cells 0.07762 Base Sequence 0.06180 Cell Differentiation 0.06992 Animals 0.05957 Animals 0.06776 Evolution, Molecular 0.04873 Mice 0.05053 Phylogeny 0.04232 Humans 0.04485 Sequence Analysis, DNA 0.04172 Hematopoietic Stem Cells 0.04157 Sequence Alignment 0.03819 Cells, Cultured 0.03013 Amino Acid Sequence 0.03706 Cell Lineage 0.02446 Genomics 0.03459 Embryo 0.02042 Genome 0.03417 Bone Marrow Cells 0.02005 Humans 0.02601 Antigens, CD34 0.01968 Conserved Sequence 0.02557 Cell Proliferation 0.01698 Computational Biology 0.02468 Hematopoiesis 0.01512 Chromosome Mapping 0.01984 DNA-Binding Proteins 0.01365 Sequence Homology, Amino Acid 0.01838 Flow Cytometry 0.01307 Sequence Homology, Nucleic Acid 0.01675 Transcription Factors 0.01210 Models, Genetic 0.01667 Stem Cell Transplantation 0.01132 Genome, Human 0.01606 Cell Line 0.01121 Genome, Bacterial 0.01362 Mice, Inbred C57BL 0.01099 Gene Duplication 0.01200 Reverse Transcriptase Polymerase Chain Reaction 0.00800 TOPIC 15 0.00916 TOPIC 16 0.00892 syndrom 0.23088 phosphoryl 0.12902 congenit 0.05099 kinas 0.11714 anomali 0.03300 akt 0.05938 retard 0.02772 activ 0.05893 report 0.02729 tyrosin 0.03541 malform 0.02620 protein 0.02934 abnorm 0.01982 phosphatas 0.02516 featur 0.01978 signal 0.02479 mental 0.01828 pten 0.02460 associ 0.01806 pi3k 0.02154 clinic 0.01755 pathwai 0.01973 case 0.01520 regul 0.01807 defect 0.01497 serin 0.01536 disord 0.01386 inhibit 0.01507 patient 0.01039 src 0.01458 development 0.00968 cell 0.01385 delai 0.00855 3-kinas 0.01302 rare 0.00844 phosphatidylinositol 0.01198 sever 0.00784 inhibitor 0.01132 describ 0.00751 rapamycin 0.01101 Humans 0.16536 Phosphorylation 0.12347 Syndrome 0.06267 Protein-Serine-Threonine Kinases 0.07595 Abnormalities, Multiple 0.05133 Proto-Oncogene Proteins 0.06069 Child 0.04644 Proto-Oncogene Proteins c-akt 0.04789 Child, Preschool 0.04150 1-Phosphatidylinositol 3-Kinase 0.04532 Infant 0.04061 Humans 0.04391 Adult 0.02916 Signal Transduction 0.03799 Infant, Newborn 0.02765 Animals 0.02854 Adolescent 0.02597 Protein Kinases 0.02146 Mental Retardation 0.02146 Tumor Suppressor Proteins 0.01632 Diagnosis, Differential 0.01399 Phosphoric Monoester Hydrolases 0.01608 Heart Defects, Congenital 0.01097 Enzyme Activation 0.01576 Growth Disorders 0.01053 Cell Line, Tumor 0.01410 Craniofacial Abnormalities 0.00887 Mice 0.01355 Fatal Outcome 0.00885 Serine 0.01319 Magnetic Resonance Imaging 0.00863 Cell Line 0.01259 Phenotype 0.00843 Cells, Cultured 0.01234 Developmental Disabilities 0.00812 PTEN Phosphohydrolase 0.01182 Chromosome Deletion 0.00758 Tyrosine 0.01127 Karyotyping 0.00725 Transfection 0.01108 TOPIC 17 0.00824 TOPIC 18 0.00806 viru 0.11840 speci 0.11129 viral 0.06386 phylogenet 0.03893 infect 0.05853 sequenc 0.02596 hiv-1 0.04772 evolut 0.02520 virus 0.03459 tree 0.02262 hiv 0.03309 lineag 0.02250 replic 0.03200 diverg 0.02120 immunodefici 0.02547 evolutionari 0.01662 envelop 0.01211 relationship 0.01504 aids 0.01166 genu 0.01478 capsid 0.01060 clade 0.01389 particl 0.01053 origin 0.01354 host 0.01050 phylogeni 0.01230 infecti 0.01019 rdna 0.01197 antiretrovir 0.00994 molecular 0.01196 human 0.00991 morpholog 0.01159 influenza 0.00954 analys 0.01156 rna 0.00951 taxa 0.01042 virion 0.00948 repres 0.00910 gag 0.00900 divers 0.00891 Humans 0.06350 Phylogeny 0.13330 HIV-1 0.06209 Animals 0.11158 HIV Infections 0.05946 Evolution, Molecular 0.06388 Virus Replication 0.04525 Molecular Sequence Data 0.05723 RNA, Viral 0.04232 Species Specificity 0.05429 Animals 0.02775 Base Sequence 0.04402 DNA, Viral 0.02747 Sequence Analysis, DNA 0.03796 Cell Line 0.02343 Evolution 0.02776 Genome, Viral 0.02246 Variation (Genetics) 0.02447 Viral Proteins 0.02133 Models, Genetic 0.02280 Molecular Sequence Data 0.01760 DNA Primers 0.01856 Anti-HIV Agents 0.01614 DNA, Ribosomal 0.01789 Viral Envelope Proteins 0.01308 DNA, Mitochondrial 0.01545 Drug Resistance, Viral 0.01194 Sequence Alignment 0.01459 Acquired Immunodeficiency Syndrome 0.01179 Geography 0.01104 Genes, Viral 0.01145 Likelihood Functions 0.01077 Capsid Proteins 0.01048 Bayes Theorem 0.00960 Viral Load 0.01016 RNA, Ribosomal 0.00771 CD4 Lymphocyte Count 0.00904 DNA, Ribosomal Spacer 0.00670 Antiretroviral Therapy, Highly Active 0.00891 Fossils 0.00654 TOPIC 19 0.00796 TOPIC 20 0.00792 polymorph 0.09484 develop 0.07543 haplotyp 0.08985 embryo 0.04064 associ 0.08675 express 0.03810 snp 0.08394 embryon 0.03655 gene 0.05430 neural 0.03233 singl 0.03855 zebrafish 0.02696 nucleotid 0.03566 notch 0.02270 allel 0.02847 pattern 0.02089 suscept 0.02393 mous 0.01776 genotyp 0.02338 vertebr 0.01562 variat 0.02152 xenopu 0.01511 linkag 0.01889 development 0.01228 genet 0.01789 signal 0.01180 disequilibrium 0.01705 earli 0.01174 popul 0.01691 embryogenesi 0.01149 region 0.01513 tube 0.01118 common 0.01451 dorsal 0.01087 individu 0.01336 hedgehog 0.01013 candid 0.01229 hox 0.00948 frequenc 0.01136 requir 0.00932 Polymorphism, Single Nucleotide 0.12094 Animals 0.10744 Humans 0.09366 Gene Expression Regulation, Developmental 0.08567 Haplotypes 0.08915 Mice 0.03363 Genetic Predisposition to Disease 0.05348 Homeodomain Proteins 0.03317 Genotype 0.05201 Transcription Factors 0.03175 Polymorphism, Genetic 0.05143 In Situ Hybridization 0.03148 Linkage Disequilibrium 0.04454 Zebrafish 0.02764 Gene Frequency 0.03769 Body Patterning 0.02482 Alleles 0.02673 Embryo, Nonmammalian 0.02144 Case-Control Studies 0.02488 Embryonic Development 0.02058 Adult 0.02441 Morphogenesis 0.01755 Middle Aged 0.02434 Signal Transduction 0.01621 Variation (Genetics) 0.02072 Trans-Activators 0.01422 Aged 0.01306 Membrane Proteins 0.01340 European Continental Ancestry Group 0.01166 Zebrafish Proteins 0.01228 Sequence Analysis, DNA 0.00982 Xenopus Proteins 0.01204 Genetic Markers 0.00940 Xenopus laevis 0.01136 Base Sequence 0.00869 Cell Differentiation 0.01134 Polymerase Chain Reaction 0.00839 Mesoderm 0.01130 DNA Mutational Analysis 0.00796 Receptors, Notch 0.01130 TOPIC 21 0.00789 TOPIC 22 0.00780 cell 0.54641 structur 0.19528 line 0.26734 conform 0.03392 human 0.05545 fold 0.03039 cytotox 0.01557 crystal 0.02363 deriv 0.01478 dimer 0.02270 establish 0.01124 form 0.01955 hela 0.00889 stabil 0.01483 k562 0.00818 loop 0.01334 kill 0.00712 residu 0.01294 vitro 0.00581 molecul 0.01126 parent 0.00470 nmr 0.01017 carcinoma 0.00462 bond 0.00980 cellular 0.00356 energi 0.00932 panel 0.00351 helic 0.00851 sublin 0.00318 interfac 0.00846 immort 0.00297 interact 0.00809 lymphoblastoid 0.00244 resolut 0.00783 assai 0.00181 monom 0.00752 coloni 0.00181 helix 0.00743 cultur 0.00159 solut 0.00729 Humans 0.20545 Models, Molecular 0.09830 Cell Line, Tumor 0.18601 Protein Conformation 0.06184 Tumor Cells, Cultured 0.05301 Crystallography, X-Ray 0.04165 Cell Line 0.05194 Protein Structure, Secondary 0.02975 Animals 0.02780 Molecular Sequence Data 0.02634 Cell Proliferation 0.02779 Protein Folding 0.02626 Cell Survival 0.02396 Thermodynamics 0.02603 Blotting, Western 0.01625 Protein Structure, Tertiary 0.02523 Transfection 0.01612 Nucleic Acid Conformation 0.02456 Gene Expression Regulation, Neoplastic 0.01600 Amino Acid Sequence 0.02355 Reverse Transcriptase Polymerase Chain Reaction 0.01518 Binding Sites 0.02328 Dose-Response Relationship, Drug 0.01379 Kinetics 0.02200 Mice 0.01180 Humans 0.02071 Hela Cells 0.01167 Dimerization 0.01954 Flow Cytometry 0.01101 Animals 0.01923 K562 Cells 0.01022 Circular Dichroism 0.01568 Cell Division 0.00992 Nuclear Magnetic Resonance, Biomolecular 0.01495 Time Factors 0.00937 Models, Chemical 0.01450 Antineoplastic Agents 0.00739 Protein Binding 0.01394 Cell Line, Transformed 0.00608 Structure-Activity Relationship 0.01318 TOPIC 23 0.00778 TOPIC 24 0.00771 neuron 0.15862 cell 0.22069 brain 0.07657 lymphocyt 0.05846 cortex 0.02627 t-cell 0.03840 cortic 0.01924 cd4 0.02218 synapt 0.01689 tcr 0.01887 neural 0.01479 immun 0.01629 motor 0.01467 cd8 0.01573 hippocamp 0.01422 cd4+ 0.01571 adult 0.01195 il-2 0.01524 hippocampu 0.01180 cytotox 0.01282 glial 0.01140 cd8+ 0.01244 area 0.01122 effector 0.01225 glutam 0.01050 killer 0.01149 nucleu 0.01045 natur 0.01136 astrocyt 0.01024 receptor 0.01052 olfactori 0.00951 thymu 0.00951 synaps 0.00863 thymocyt 0.00929 region 0.00773 thymic 0.00839 neuroprotect 0.00765 subset 0.00827 sensori 0.00751 memori 0.00809 Neurons 0.09727 T-Lymphocytes 0.06891 Animals 0.09151 Lymphocyte Activation 0.04476 Brain 0.06164 Humans 0.03757 Rats 0.04536 CD4-Positive T-Lymphocytes 0.03181 Nerve Tissue Proteins 0.03937 Animals 0.03041 Immunohistochemistry 0.03545 Killer Cells, Natural 0.02856 Hippocampus 0.02623 Mice 0.02672 Cerebral Cortex 0.01904 Antigens, CD 0.02615 Rats, Sprague-Dawley 0.01459 CD8-Positive T-Lymphocytes 0.02526 Animals, Newborn 0.01332 Mice, Inbred C57BL 0.01893 Cells, Cultured 0.01096 Thymus Gland 0.01856 Synapses 0.01061 Flow Cytometry 0.01855 Rats, Wistar 0.00976 B-Lymphocytes 0.01707 Time Factors 0.00951 Interleukin-2 0.01705 Cell Count 0.00948 Receptors, Antigen, T-Cell 0.01620 Synaptic Transmission 0.00916 T-Lymphocyte Subsets 0.01554 Mice 0.00893 Lymphocytes 0.01553 Neuroglia 0.00809 Membrane Glycoproteins 0.01401 Cerebellum 0.00782 Cells, Cultured 0.01190 Astrocytes 0.00762 Cell Proliferation 0.01173 TOPIC 25 0.00765 TOPIC 26 0.00762 chromosom 0.23965 breast 0.37050 aberr 0.03461 cancer 0.32487 transloc 0.03204 women 0.03556 cytogenet 0.03017 tamoxifen 0.02755 delet 0.02558 mcf-7 0.02602 abnorm 0.02503 estrogen 0.01110 rearrang 0.02493 mda-mb-231 0.00721 genom 0.02311 statu 0.00720 karyotyp 0.02300 adjuv 0.00690 gain 0.01417 hormon 0.00605 loss 0.01308 tam 0.00604 region 0.01138 mammari 0.00549 arm 0.01121 ductal 0.00548 breakpoint 0.01109 aromatas 0.00547 trisomi 0.01084 postmenopaus 0.00541 mosaic 0.01081 anastrozol 0.00460 duplic 0.01071 endocrin 0.00450 cgh 0.01052 letrozol 0.00426 case 0.00895 axillari 0.00399 imbal 0.00892 earli 0.00370 Humans 0.08007 Breast Neoplasms 0.31929 In Situ Hybridization, Fluorescence 0.07723 Humans 0.12066 Chromosome Aberrations 0.07384 Middle Aged 0.02422 Karyotyping 0.06449 Receptors, Estrogen 0.02308 Translocation, Genetic 0.03782 Tamoxifen 0.02297 Chromosome Mapping 0.02366 Antineoplastic Agents, Hormonal 0.01702 Nucleic Acid Hybridization 0.02163 Aged 0.01691 Chromosome Banding 0.02082 Carcinoma, Ductal, Breast 0.01353 Chromosome Deletion 0.01900 Chemotherapy, Adjuvant 0.01333 Adult 0.01696 Mammography 0.01297 Cytogenetic Analysis 0.01490 Breast 0.01244 Aneuploidy 0.01477 Adult 0.01198 Chromosomes 0.01419 Neoplasm Staging 0.01030 Trisomy 0.01318 Aromatase Inhibitors 0.00946 Chromosomes, Human 0.01101 Neoplasms 0.00941 Gene Rearrangement 0.00939 Receptors, Progesterone 0.00902 Chromosomes, Human, Pair 8 0.00935 Postmenopause 0.00857 Chromosomes, Human, Pair 1 0.00932 Prognosis 0.00836 Mosaicism 0.00916 Mastectomy 0.00814 Chromosomes, Human, X 0.00909 Antineoplastic Agents 0.00784 TOPIC 27 0.00740 TOPIC 28 0.00738 fetal 0.06078 patient 0.10554 pregnanc 0.05981 chemotherapi 0.08857 matern 0.05288 therapi 0.04293 birth 0.04791 surviv 0.04255 infant 0.03880 treatment 0.03755 neonat 0.03707 relaps 0.02770 prenat 0.03375 treat 0.02153 gestat 0.03095 adjuv 0.02078 mother 0.02248 receiv 0.02012 week 0.01896 radiotherapi 0.01875 women 0.01841 complet 0.01771 deliveri 0.01621 remiss 0.01750 pregnant 0.01556 regimen 0.01738 fetu 0.01335 diseas 0.01337 fetus 0.01196 cyclophosphamid 0.01307 placent 0.01182 achiev 0.01186 placenta 0.01151 advanc 0.01156 preterm 0.01134 refractori 0.01144 newborn 0.01107 rate 0.01124 abort 0.01035 improv 0.01023 Pregnancy 0.18145 Humans 0.09750 Humans 0.08728 Antineoplastic Combined Chemotherapy Protocols 0.07709 Infant, Newborn 0.08506 Treatment Outcome 0.04993 Adult 0.04000 Combined Modality Therapy 0.04024 Prenatal Diagnosis 0.02926 Middle Aged 0.03214 Gestational Age 0.02349 Antineoplastic Agents 0.02946 Pregnancy Outcome 0.01991 Cyclophosphamide 0.02851 Ultrasonography, Prenatal 0.01929 Adult 0.02839 Fetus 0.01695 Chemotherapy, Adjuvant 0.02603 Pregnancy Complications 0.01400 Survival Analysis 0.02347 Fetal Diseases 0.01219 Disease-Free Survival 0.02267 Placenta 0.01200 Doxorubicin 0.01904 Pregnancy Trimester, First 0.01132 Remission Induction 0.01887 Maternal Age 0.01016 Aged 0.01734 Infant, Premature 0.01003 Neoplasm Recurrence, Local 0.01631 Infant 0.00942 Neoplasm Staging 0.01561 Birth Weight 0.00825 Prognosis 0.01533 Down Syndrome 0.00809 Survival Rate 0.01452 Risk Factors 0.00775 Methotrexate 0.01236 Cesarean Section 0.00693 Recurrence 0.01211 TOPIC 29 0.00715 TOPIC 30 0.00709 carcinoma 0.20725 vivo 0.17192 node 0.05863 vitro 0.12518 lymph 0.04884 mice 0.07378 tumor 0.04042 model 0.05634 squamou 0.03824 human 0.05344 grade 0.03152 growth 0.04387 correl 0.03118 xenograft 0.03263 invas 0.02097 antitumor 0.02450 immunohistochem 0.01853 inhibit 0.02279 case 0.01851 nude 0.02222 posit 0.01720 inject 0.02124 histolog 0.01621 murin 0.02038 stage 0.01582 effect 0.01884 scc 0.01560 bear 0.01380 metastasi 0.01366 mous 0.01284 signific 0.01157 anim 0.01263 ki-67 0.01130 scid 0.01155 specimen 0.01095 establish 0.01103 stain 0.01077 surviv 0.01024 immunohistochemistri 0.00983 therapeut 0.00974 Humans 0.08805 Mice 0.20869 Middle Aged 0.08225 Animals 0.19218 Aged 0.07825 Mice, Nude 0.07326 Immunohistochemistry 0.07633 Mice, Inbred BALB C 0.04327 Carcinoma, Squamous Cell 0.07431 Cell Line, Tumor 0.04016 Adult 0.04391 Neoplasm Transplantation 0.03903 Tumor Markers, Biological 0.04202 Transplantation, Heterologous 0.03733 Lymphatic Metastasis 0.04138 Mice, SCID 0.02941 Aged, 80 and over 0.03546 Xenograft Model Antitumor Assays 0.02832 Neoplasm Staging 0.02698 Disease Models, Animal 0.01944 Lymph Nodes 0.02402 Tumor Cells, Cultured 0.01511 Carcinoma 0.02294 Mice, Inbred C57BL 0.01149 Ki-67 Antigen 0.01908 Neoplasms, Experimental 0.00903 Neoplasm Invasiveness 0.01879 Cell Proliferation 0.00837 Adenocarcinoma 0.01528 Humans 0.00705 Prognosis 0.01377 Time Factors 0.00680 Disease Progression 0.01092 Melanoma, Experimental 0.00520 Gene Expression Regulation, Neoplastic 0.01035 Antineoplastic Agents 0.00459 Esophageal Neoplasms 0.00994 Gene Therapy 0.00419 Neoplasm Proteins 0.00801 Apoptosis 0.00393 TOPIC 31 0.00708 TOPIC 32 0.00707 children 0.22600 gene 0.21592 adult 0.11191 profil 0.10634 year 0.05617 microarrai 0.10517 parent 0.05509 analysi 0.05055 young 0.05145 arrai 0.04199 child 0.03552 express 0.04004 childhood 0.03294 identifi 0.03698 adolesc 0.03288 cdna 0.02155 pediatr 0.03261 differenti 0.01721 height 0.01865 data 0.01495 boi 0.01819 set 0.01362 girl 0.01788 global 0.01341 old 0.01778 signatur 0.01319 mother 0.01177 oligonucleotid 0.01176 statur 0.00973 transcript 0.01163 school 0.00957 transcriptom 0.01046 problem 0.00953 chip 0.00975 infant 0.00952 valid 0.00963 older 0.00918 compar 0.00918 adulthood 0.00879 technolog 0.00862 Child 0.22956 Oligonucleotide Array Sequence Analysis 0.25387 Child, Preschool 0.12131 Gene Expression Profiling 0.19994 Adolescent 0.11488 Humans 0.05762 Humans 0.08606 Reverse Transcriptase Polymerase Chain Reaction 0.02698 Infant 0.07985 Gene Expression Regulation 0.02299 Age Factors 0.02448 Gene Expression Regulation, Neoplastic 0.02109 Adult 0.01769 RNA, Messenger 0.01865 Infant, Newborn 0.01436 Gene Expression 0.01695 Body Height 0.01058 DNA, Complementary 0.01667 Parents 0.01028 Transcription, Genetic 0.01600 Growth Disorders 0.00590 Cluster Analysis 0.01554 Risk Factors 0.00531 Microarray Analysis 0.01422 Aging 0.00502 Animals 0.01420 Severity of Illness Index 0.00440 Reproducibility of Results 0.01351 Follow-Up Studies 0.00435 RNA 0.00898 Pediatrics 0.00370 Computational Biology 0.00771 Cross-Sectional Studies 0.00353 Up-Regulation 0.00740 Child Development 0.00316 Nucleic Acid Hybridization 0.00692 Parent-Child Relations 0.00287 Polymerase Chain Reaction 0.00578 Mothers 0.00268 Genomics 0.00482 TOPIC 33 0.00679 TOPIC 34 0.00663 immun 0.12176 cell 0.16053 vaccin 0.10325 cycl 0.14103 respons 0.06471 cyclin 0.07902 antigen 0.04963 arrest 0.05784 protect 0.02279 p21 0.03337 immunotherapi 0.02189 phase 0.03134 ctl 0.02167 prolifer 0.02796 epitop 0.02087 progress 0.02766 dendrit 0.01785 p27 0.02587 induc 0.01766 regul 0.01999 cell 0.01615 kinas 0.01864 challeng 0.01504 cyclin-depend 0.01429 immunogen 0.01372 retinoblastoma 0.01351 cytotox 0.01101 inhibitor 0.01302 t-cell 0.01099 cdk2 0.01078 elicit 0.00967 cip1 0.01072 immunolog 0.00936 cell-cycl 0.01067 cd8+ 0.00858 cdk 0.01044 prime 0.00840 prb 0.01034 lymphocyt 0.00834 waf1 0.01003 Animals 0.06326 Cell Cycle 0.11518 Cancer Vaccines 0.04963 Cell Cycle Proteins 0.09759 Humans 0.03594 Cell Proliferation 0.03844 Dendritic Cells 0.03547 Humans 0.03720 T-Lymphocytes, Cytotoxic 0.03502 Cyclin-Dependent Kinase Inhibitor p21 0.03494 Antigens, Neoplasm 0.03470 Cyclin-Dependent Kinase Inhibitor p27 0.02717 Immunotherapy 0.02863 Tumor Suppressor Proteins 0.02503 T-Lymphocytes 0.02344 Cyclin D1 0.02452 Mice 0.02172 G1 Phase 0.02411 Vaccines, DNA 0.02008 Cyclin-Dependent Kinases 0.02242 CD8-Positive T-Lymphocytes 0.01978 S Phase 0.01989 Mice, Inbred BALB C 0.01899 Retinoblastoma Protein 0.01979 Vaccination 0.01865 Cyclins 0.01862 Interferon Type II 0.01337 Cell Line, Tumor 0.01774 Epitopes 0.01332 Cell Division 0.01486 Lymphocyte Activation 0.01306 G2 Phase 0.01214 Epitopes, T-Lymphocyte 0.01288 E2F Transcription Factors 0.01167 Mice, Inbred C57BL 0.01182 Phosphorylation 0.01086 Antigen Presentation 0.01085 Cyclin-Dependent Kinase 2 0.01055 Immunization 0.01043 CDC2-CDC28 Kinases 0.01022 TOPIC 35 0.00656 TOPIC 36 0.00646 plant 0.15475 clone 0.15119 arabidopsi 0.04535 sequenc 0.12336 root 0.03368 cdna 0.07140 seed 0.03258 librari 0.04436 leav 0.02779 gene 0.04187 flower 0.02180 analysi 0.02740 leaf 0.01959 tag 0.02535 transgen 0.01826 homolog 0.02303 thaliana 0.01645 est 0.02150 pollen 0.01398 identifi 0.02107 seedl 0.01214 character 0.01943 tomato 0.01200 isol 0.01834 speci 0.00983 encod 0.01598 tobacco 0.00924 contain 0.01579 germin 0.00887 bac 0.01561 floral 0.00787 genom 0.01523 rice 0.00678 construct 0.01483 fruit 0.00673 ident 0.01404 shoot 0.00673 novel 0.01403 mosaic 0.00646 full-length 0.01040 Arabidopsis 0.07930 Molecular Sequence Data 0.12104 Gene Expression Regulation, Plant 0.06252 Cloning, Molecular 0.10457 Plant Leaves 0.04893 Base Sequence 0.08188 Arabidopsis Proteins 0.04482 Amino Acid Sequence 0.07741 Plants, Genetically Modified 0.04457 DNA, Complementary 0.07398 Plant Proteins 0.04305 Gene Library 0.04463 Genes, Plant 0.03920 Sequence Analysis, DNA 0.04363 Flowers 0.02741 Animals 0.03067 Plants 0.02726 Sequence Homology, Amino Acid 0.03047 Plant Diseases 0.02678 Sequence Alignment 0.03047 DNA, Plant 0.02486 Expressed Sequence Tags 0.02908 Seeds 0.02477 Phylogeny 0.01344 Plant Roots 0.02439 DNA Primers 0.01313 Tobacco 0.01847 Polymerase Chain Reaction 0.00962 Genome, Plant 0.01425 Chromosomes, Artificial, Bacterial 0.00908 Lycopersicon esculentum 0.01027 Reverse Transcriptase Polymerase Chain Reaction 0.00891 Pollen 0.01016 Blotting, Northern 0.00755 RNA, Plant 0.01002 Sequence Homology, Nucleic Acid 0.00646 Oryza sativa 0.00976 Gene Expression Profiling 0.00634 Transformation, Genetic 0.00952 Blotting, Southern 0.00595 TOPIC 37 0.00641 TOPIC 38 0.00637 case 0.35280 express 0.40998 report 0.11386 mrna 0.20493 rare 0.04901 level 0.11576 present 0.04583 protein 0.04250 diagnosi 0.02995 rt-pcr 0.04141 literatur 0.02235 transcript 0.02403 diagnos 0.02036 expression 0.01982 woman 0.01715 quantit 0.01192 man 0.01465 real-tim 0.01068 unusu 0.01219 revers 0.00989 reveal 0.01137 tissu 0.00958 describ 0.01121 correl 0.00837 occur 0.01071 regul 0.00659 author 0.01006 abund 0.00640 clinic 0.00940 upregul 0.00557 bilater 0.00923 messeng 0.00433 year 0.00809 examin 0.00416 right 0.00799 semi-quantit 0.00389 histori 0.00784 transcription-pcr 0.00385 extrem 0.00765 immunohistochemistri 0.00366 Humans 0.26726 RNA, Messenger 0.29284 Adult 0.13220 Reverse Transcriptase Polymerase Chain Reaction 0.16306 Middle Aged 0.07034 Gene Expression 0.05106 Aged 0.04351 Gene Expression Regulation 0.03517 Diagnosis, Differential 0.04043 Gene Expression Regulation, Neoplastic 0.02765 Fatal Outcome 0.01991 Humans 0.02044 Tomography, X-Ray Computed 0.01801 Gene Expression Profiling 0.02011 Adolescent 0.01664 Base Sequence 0.01839 Child 0.01306 Immunohistochemistry 0.01640 Magnetic Resonance Imaging 0.01205 Blotting, Northern 0.01481 Infant 0.01136 DNA Primers 0.01392 Follow-Up Studies 0.01083 Blotting, Western 0.01382 Child, Preschool 0.00938 Up-Regulation 0.01369 Treatment Outcome 0.00872 Transcription, Genetic 0.01110 Biopsy 0.00684 DNA, Complementary 0.00957 Infant, Newborn 0.00381 DNA-Binding Proteins 0.00810 Aged, 80 and over 0.00342 Cells, Cultured 0.00712 Retrospective Studies 0.00330 Transcription Factors 0.00666 Neoplasms, Multiple Primary 0.00309 Gene Expression Regulation, Enzymologic 0.00650 Hamartoma 0.00222 In Situ Hybridization 0.00607 TOPIC 39 0.00629 TOPIC 40 0.00628 research 0.02944 rat 0.30720 nation 0.02740 anim 0.11523 medic 0.02357 model 0.04919 institut 0.01661 effect 0.04131 medicin 0.01584 control 0.02891 internat 0.01527 inject 0.02203 societi 0.01500 experiment 0.02044 univers 0.01376 induc 0.02026 meet 0.01371 administr 0.01780 scienc 0.01317 increas 0.01542 work 0.01220 compar 0.01437 world 0.01204 rodent 0.01338 scientif 0.01121 dai 0.01191 health 0.01103 treat 0.01116 collabor 0.01045 week 0.01098 centuri 0.01035 decreas 0.01043 center 0.01010 examin 0.00947 industri 0.01004 reduc 0.00855 present 0.00953 animal 0.00852 recommend 0.00872 wistar 0.00840 Humans 0.17038 Rats 0.32684 United States 0.04554 Animals 0.22704 History, 20th Century 0.04009 Rats, Sprague-Dawley 0.08144 Animals 0.03188 Rats, Wistar 0.06781 History, 19th Century 0.01775 Disease Models, Animal 0.04103 History, 21st Century 0.01505 Rats, Inbred F344 0.01567 Portraits 0.01418 Rats, Inbred Strains 0.00660 Great Britain 0.01164 Carcinogens 0.00557 Germany 0.01136 Models, Animal 0.00466 France 0.00801 Time Factors 0.00429 Societies, Medical 0.00697 Rats, Inbred Lew 0.00424 International Cooperation 0.00662 Animals, Newborn 0.00244 Europe 0.00648 Animals, Genetically Modified 0.00229 Drug Industry 0.00648 Random Allocation 0.00220 Research 0.00643 Behavior, Animal 0.00201 Neoplasms 0.00620 Organ Size 0.00178 Canada 0.00610 Injections, Intraperitoneal 0.00171 Biomedical Research 0.00566 Aging 0.00169 Research Support 0.00490 Dose-Response Relationship, Drug 0.00161 History, 18th Century 0.00472 Species Specificity 0.00161 TOPIC 41 0.00621 TOPIC 42 0.00611 kinas 0.10610 dna 0.18173 activ 0.09372 repair 0.10942 protein 0.04462 damag 0.10582 pathwai 0.04444 break 0.03479 phosphoryl 0.03810 dsb 0.01626 signal 0.03808 excis 0.01585 mapk 0.03431 atm 0.01526 erk 0.03213 double-strand 0.01404 inhibit 0.02938 strand 0.01150 inhibitor 0.02661 pathwai 0.01075 p38 0.02527 checkpoint 0.01049 jnk 0.02235 comet 0.00951 mitogen-activ 0.01906 rad51 0.00784 erk1 0.01696 foci 0.00756 pkc 0.01693 lesion 0.00750 induc 0.01437 assai 0.00743 cell 0.01309 xrcc1 0.00676 extracellular 0.01300 recombin 0.00634 regul 0.01188 cellular 0.00615 signal-regul 0.01050 homolog 0.00604 Phosphorylation 0.05987 DNA Damage 0.14594 Signal Transduction 0.05794 DNA Repair 0.11446 Enzyme Activation 0.04254 DNA-Binding Proteins 0.06794 MAP Kinase Signaling System 0.04092 Humans 0.04754 Animals 0.03439 DNA 0.03775 Extracellular Signal-Regulated MAP Kinases 0.03197 Cell Cycle Proteins 0.02384 Protein Kinase C 0.02939 Animals 0.02194 p38 Mitogen-Activated Protein Kinases 0.02776 Ultraviolet Rays 0.02146 Mitogen-Activated Protein Kinases 0.02679 Nuclear Proteins 0.01927 Humans 0.02448 Protein-Serine-Threonine Kinases 0.01726 Enzyme Inhibitors 0.02324 Recombination, Genetic 0.01660 Mitogen-Activated Protein Kinase 3 0.02284 Comet Assay 0.01619 JNK Mitogen-Activated Protein Kinases 0.02273 DNA Glycosylases 0.01169 Mitogen-Activated Protein Kinase 1 0.02174 Fibroblasts 0.01006 Cell Line, Tumor 0.01814 Cell Line 0.00975 Cells, Cultured 0.01777 Tumor Suppressor Proteins 0.00973 Mice 0.01609 DNA Repair Enzymes 0.00832 Protein-Serine-Threonine Kinases 0.01533 Cells, Cultured 0.00756 Blotting, Western 0.01422 Mutation 0.00746 Tetradecanoylphorbol Acetate 0.01219 Rad51 Recombinase 0.00708 TOPIC 43 0.00609 TOPIC 44 0.00598 patient 0.18503 macrophag 0.05706 month 0.12001 cytokin 0.04938 year 0.11859 respons 0.03728 median 0.05436 immun 0.03650 follow-up 0.05213 product 0.03376 rang 0.04553 ifn-gamma 0.02830 mean 0.03984 il-10 0.02570 long-term 0.03040 cell 0.02274 methods 0.01643 ifn 0.02146 time 0.01433 interferon 0.02069 evalu 0.01194 monocyt 0.01860 period 0.01171 induc 0.01853 durat 0.01133 dendrit 0.01820 baselin 0.01007 il-4 0.01685 conclusions 0.00998 lps 0.01517 follow 0.00911 innat 0.01455 retrospect 0.00891 stimul 0.01383 total 0.00842 il-12 0.01373 receiv 0.00832 receptor 0.01364 prospect 0.00785 ifn-alpha 0.01236 Middle Aged 0.11968 Interferon Type II 0.04665 Adult 0.11961 Cytokines 0.04634 Humans 0.08752 Macrophages 0.04425 Follow-Up Studies 0.07597 Membrane Glycoproteins 0.03221 Aged 0.06336 Receptors, Cell Surface 0.03098 Adolescent 0.05556 Dendritic Cells 0.02970 Retrospective Studies 0.05065 Lipopolysaccharides 0.02664 Treatment Outcome 0.04252 Interleukin-10 0.02521 Prospective Studies 0.03572 Toll-Like Receptors 0.02303 Time Factors 0.02939 Animals 0.02279 Aged, 80 and over 0.02109 Cells, Cultured 0.02087 Child 0.01841 Interleukin-12 0.01979 Child, Preschool 0.01648 Interleukin-4 0.01830 Age Factors 0.00672 Mice 0.01827 Disease Progression 0.00638 Monocytes 0.01779 Longitudinal Studies 0.00551 Th1 Cells 0.01453 Infant 0.00503 Interferon-alpha 0.01411 Incidence 0.00429 Humans 0.01339 Recurrence 0.00346 Immunity, Natural 0.01316 Prognosis 0.00328 DNA-Binding Proteins 0.01264 TOPIC 45 0.00589 TOPIC 46 0.00570 vector 0.12488 leukemia 0.12846 gene 0.07490 acut 0.11063 transfer 0.06559 myeloid 0.05263 express 0.03263 aml 0.05124 effici 0.03193 mds 0.02820 adenoviru 0.03160 lymphoblast 0.02300 therapi 0.03006 leukaemia 0.02073 deliveri 0.02872 blast 0.01814 transduct 0.02289 leukem 0.01807 transgen 0.02284 patient 0.01721 adenovir 0.01980 myelodysplast 0.01539 transduc 0.01870 marrow 0.01483 recombin 0.01687 syndrom 0.01454 inject 0.01330 malign 0.01239 retrovir 0.01202 flt3 0.01198 vivo 0.01178 bone 0.01118 viral 0.01052 promyelocyt 0.01111 deliv 0.00985 hematolog 0.01056 lentivir 0.00965 mll 0.01055 aav 0.00841 granulocyt 0.00894 Genetic Vectors 0.15033 Humans 0.09023 Gene Therapy 0.09783 Acute Disease 0.06232 Adenoviridae 0.07648 Leukemia, Myeloid 0.04882 Animals 0.06163 Myelodysplastic Syndromes 0.03576 Gene Transfer Techniques 0.06035 Leukemia 0.03186 Transduction, Genetic 0.04519 Leukemia, Myelocytic, Acute 0.03061 Humans 0.02909 Leukemia, Lymphocytic, Acute 0.02248 Transgenes 0.02110 Middle Aged 0.02153 Dependovirus 0.02020 Child 0.01830 Retroviridae 0.01777 Adult 0.01738 Gene Expression 0.01771 Adolescent 0.01711 Lentivirus 0.01401 Leukemia, Promyelocytic, Acute 0.01665 Cell Line 0.01311 Aged 0.01561 Mice 0.01116 Oncogene Proteins, Fusion 0.01411 Green Fluorescent Proteins 0.01086 Transcription Factors 0.01219 beta-Galactosidase 0.00954 Child, Preschool 0.01179 Transfection 0.00872 Bone Marrow 0.01161 Recombinant Proteins 0.00791 Proto-Oncogene Proteins 0.01152 Adenoviruses, Human 0.00765 Antineoplastic Agents 0.01008 Plasmids 0.00748 Bone Marrow Cells 0.01008 TOPIC 47 0.00554 TOPIC 48 0.00549 year 0.09849 nuclear 0.18762 incid 0.09511 protein 0.07696 mortal 0.06647 degrad 0.06574 rate 0.04195 cytoplasm 0.06568 older 0.02762 nucleu 0.05120 elderli 0.02661 ubiquitin 0.03909 cohort 0.02570 local 0.03608 trend 0.02052 proteasom 0.03258 data 0.02021 ligas 0.02203 increas 0.01946 nuclei 0.02130 popul 0.01835 accumul 0.01941 period 0.01776 export 0.01833 registri 0.01589 transloc 0.01828 diagnos 0.01553 cellular 0.01244 younger 0.01353 stabil 0.01222 morbid 0.01265 import 0.01196 death 0.01207 target 0.01085 estim 0.01187 lamin 0.00940 regist 0.01110 nls 0.00664 risk 0.01083 nucleolar 0.00609 Aged 0.09281 Cell Nucleus 0.14179 Incidence 0.07366 Cytoplasm 0.05203 Middle Aged 0.06842 Animals 0.04820 Humans 0.06486 Ubiquitin 0.04756 Adult 0.05220 Proteasome Endopeptidase Complex 0.04648 Aged, 80 and over 0.04132 Humans 0.04367 Registries 0.03942 Active Transport, Cell Nucleus 0.03159 Age Factors 0.03555 Nuclear Proteins 0.03056 Cohort Studies 0.03466 Ubiquitin-Protein Ligases 0.02617 Risk Factors 0.02459 Cell Line 0.02024 Adolescent 0.02421 Hela Cells 0.01930 Age Distribution 0.02378 Protein Transport 0.01814 Sex Distribution 0.01448 Mice 0.01279 Sweden 0.01228 Protein Binding 0.01178 United States 0.01102 Transfection 0.01110 Aging 0.01086 Nuclear Localization Signals 0.01092 Child 0.01084 Microscopy, Fluorescence 0.01070 Infant 0.01021 COS Cells 0.00878 Child, Preschool 0.00981 Immunoprecipitation 0.00860 Infant, Newborn 0.00930 Protein Structure, Tertiary 0.00802 TOPIC 49 0.00541 TOPIC 50 0.00537 mutant 0.31527 mutat 0.06411 wild-typ 0.08708 domin 0.05750 mutat 0.06957 autosom 0.05617 defect 0.03611 inherit 0.05371 phenotyp 0.02743 famili 0.05063 delet 0.02274 disord 0.04420 wild 0.02080 recess 0.03755 function 0.01638 affect 0.03753 rescu 0.01565 caus 0.03289 requir 0.01559 hereditari 0.03079 lack 0.01526 diseas 0.03050 exhibit 0.01490 clinic 0.02713 reduc 0.01455 genet 0.02596 null 0.01375 phenotyp 0.01769 suggest 0.01238 gene 0.01615 essenti 0.01207 character 0.01574 disrupt 0.01192 syndrom 0.01448 mutagenesi 0.01124 rare 0.01172 lethal 0.01063 heterogen 0.01057 affect 0.00985 form 0.01044 Mutation 0.30223 Humans 0.14557 Phenotype 0.05279 Pedigree 0.08622 Gene Deletion 0.03617 Mutation 0.05821 Molecular Sequence Data 0.03163 Adult 0.03177 Amino Acid Sequence 0.02790 Phenotype 0.02823 Animals 0.02627 Child 0.02742 Mutagenesis 0.02262 DNA Mutational Analysis 0.02593 Mutagenesis, Site-Directed 0.01618 Genes, Dominant 0.02505 Base Sequence 0.01484 Family Health 0.02474 Point Mutation 0.01472 Genes, Recessive 0.02460 Genetic Complementation Test 0.01385 Genetic Predisposition to Disease 0.01990 Alleles 0.01079 Adolescent 0.01912 Cell Line 0.01004 Middle Aged 0.01436 Amino Acid Substitution 0.00920 Child, Preschool 0.01383 Sequence Deletion 0.00797 Age of Onset 0.01230 Protein Structure, Tertiary 0.00764 Genetic Screening 0.01099 Membrane Proteins 0.00754 Consanguinity 0.01062 Sequence Homology, Amino Acid 0.00693 Syndrome 0.01050 Saccharomyces cerevisiae Proteins 0.00645 Genotype 0.00989 Temperature 0.00626 Infant 0.00977 TOPIC 51 0.00526 TOPIC 52 0.00523 cell 0.79118 histon 0.10582 prolifer 0.12545 chromatin 0.08784 cellular 0.01612 acetyl 0.03394 prolif 0.00977 transcript 0.03202 pcna 0.00759 modif 0.02861 incorpor 0.00410 deacetylas 0.02416 quiescent 0.00398 activ 0.02076 brdu 0.00342 recruit 0.02008 label 0.00266 hdac 0.01933 mitogen 0.00206 remodel 0.01899 viabil 0.00172 silenc 0.01665 antigen 0.00156 nucleosom 0.01618 rcas1 0.00152 regul 0.01615 type 0.00136 repress 0.01569 bromodeoxyuridin 0.00130 p300 0.01399 cycl 0.00128 lysin 0.01154 cell-specif 0.00128 structur 0.01146 single-cel 0.00127 cbp 0.01141 pre-b 0.00095 associ 0.01129 line 0.00083 heterochromatin 0.01077 Cell Proliferation 0.16874 Histones 0.09419 Humans 0.10393 Chromatin 0.07669 Animals 0.09197 Histone Deacetylases 0.05368 Cell Line, Tumor 0.05875 Acetylation 0.04292 Cell Division 0.03828 Transcription, Genetic 0.03203 Cells, Cultured 0.03653 Animals 0.02991 Mice 0.02630 Nuclear Proteins 0.02102 Cell Survival 0.02530 Transcription Factors 0.02089 Cell Line 0.01562 Nucleosomes 0.02077 Tumor Cells, Cultured 0.01410 Gene Silencing 0.01970 Flow Cytometry 0.01046 Chromatin Immunoprecipitation 0.01831 Proliferating Cell Nuclear Antigen 0.01002 Acetyltransferases 0.01817 Immunohistochemistry 0.00941 Humans 0.01810 Cell Differentiation 0.00914 Hydroxamic Acids 0.01804 Apoptosis 0.00850 DNA-Binding Proteins 0.01749 Cell Cycle 0.00839 Chromatin Assembly and Disassembly 0.01666 Time Factors 0.00821 Methylation 0.01598 Bromodeoxyuridine 0.00552 Repressor Proteins 0.01502 Cell Movement 0.00439 Lysine 0.01500 Rats 0.00435 Histone Acetyltransferases 0.01487 TOPIC 53 0.00521 TOPIC 54 0.00514 patient 0.06160 oxid 0.13121 surgeri 0.06151 antioxid 0.03669 surgic 0.04949 oxygen 0.03649 recurr 0.04560 stress 0.03496 oper 0.03241 reactiv 0.03365 complic 0.03144 nitric 0.02716 procedur 0.02552 radic 0.02467 postop 0.02330 damag 0.02401 resect 0.02148 protect 0.02127 underw 0.01945 speci 0.02054 perform 0.01891 ros 0.02018 manag 0.01588 peroxid 0.01850 preoper 0.01458 increas 0.01781 case 0.01163 product 0.01673 techniqu 0.01033 glutathion 0.01555 remov 0.00932 superoxid 0.01498 success 0.00926 free 0.01255 undergo 0.00907 synthas 0.01233 anesthesia 0.00739 enzym 0.01120 laparoscop 0.00692 reduc 0.01115 Humans 0.15252 Oxidative Stress 0.08918 Treatment Outcome 0.05888 Antioxidants 0.05460 Middle Aged 0.05191 Reactive Oxygen Species 0.05407 Adult 0.04903 Oxidation-Reduction 0.04829 Aged 0.03824 Nitric Oxide Synthase 0.04155 Postoperative Complications 0.03250 Animals 0.03895 Retrospective Studies 0.02621 Nitric Oxide 0.03814 Follow-Up Studies 0.02305 Superoxide Dismutase 0.03144 Recurrence 0.01716 Hydrogen Peroxide 0.03073 Aged, 80 and over 0.01304 Glutathione 0.02421 Adolescent 0.01228 Lipid Peroxidation 0.02350 Neoplasm Recurrence, Local 0.01022 Oxygen 0.01591 Reoperation 0.00980 Nitric Oxide Synthase Type II 0.01527 Child 0.00896 Catalase 0.01427 Prospective Studies 0.00848 Nitric Oxide Synthase Type III 0.01382 Laparoscopy 0.00806 Humans 0.01357 Infant 0.00747 Free Radicals 0.01188 Risk Assessment 0.00740 DNA Damage 0.01137 Tomography, X-Ray Computed 0.00707 Free Radical Scavengers 0.00968 Time Factors 0.00656 Oxidants 0.00879 TOPIC 55 0.00509 TOPIC 56 0.00508 popul 0.23363 diabet 0.16122 genet 0.08939 insulin 0.09637 divers 0.03369 glucos 0.06212 loci 0.03060 obes 0.05133 structur 0.02419 metabol 0.02388 variat 0.02132 bmi 0.02250 distanc 0.01678 fast 0.02092 microsatellit 0.01518 mellitu 0.02039 individu 0.01323 leptin 0.01727 str 0.01286 subject 0.01686 frequenc 0.01243 bodi 0.01637 marker 0.01229 mass 0.01543 differenti 0.00966 adipos 0.01504 flow 0.00953 index 0.01273 dispers 0.00945 associ 0.01224 allel 0.00918 resist 0.01166 geograph 0.00839 adiponectin 0.01161 inbreed 0.00837 fat 0.01146 distribut 0.00829 toler 0.01090 estim 0.00736 nod 0.01003 Genetics, Population 0.10969 Diabetes Mellitus, Type 2 0.07481 Variation (Genetics) 0.09194 Insulin 0.07040 Gene Frequency 0.05142 Obesity 0.06242 Microsatellite Repeats 0.04726 Humans 0.04567 Animals 0.03412 Diabetes Mellitus, Type 1 0.04258 Humans 0.03259 Blood Glucose 0.04241 Tandem Repeat Sequences 0.03223 Insulin Resistance 0.03825 Polymerase Chain Reaction 0.02815 Body Mass Index 0.03628 Population Dynamics 0.02736 Glucose 0.02832 Geography 0.02574 Diabetes Mellitus 0.02327 DNA Fingerprinting 0.02171 Adipose Tissue 0.01876 Haplotypes 0.01975 Adult 0.01806 Demography 0.01618 Hypoglycemic Agents 0.01794 Polymorphism, Genetic 0.01583 Leptin 0.01476 Chromosomes, Human, Y 0.01452 Islets of Langerhans 0.01429 Genetic Markers 0.01303 Middle Aged 0.01235 Models, Genetic 0.01150 Glucose Tolerance Test 0.01178 Alleles 0.01101 Adiponectin 0.00861 Species Specificity 0.01023 Intercellular Signaling Peptides and Proteins 0.00859 Genotype 0.00963 Diabetes Mellitus, Experimental 0.00827 TOPIC 57 0.00502 TOPIC 58 0.00502 endotheli 0.13122 mitot 0.04702 vegf 0.09380 microtubul 0.03770 vascular 0.08949 chromosom 0.03749 angiogenesi 0.07264 spindl 0.03387 growth 0.06500 divis 0.03287 factor 0.06307 mitosi 0.02367 vessel 0.02919 cell 0.02360 cell 0.02104 segreg 0.02016 angiogen 0.02045 yeast 0.01887 endostatin 0.01278 meiotic 0.01739 antiangiogen 0.01263 centrosom 0.01715 microvessel 0.01129 checkpoint 0.01502 densiti 0.01097 meiosi 0.01401 blood 0.01042 fission 0.01282 huvec 0.00915 centromer 0.01278 endothelium 0.00904 requir 0.01243 capillari 0.00871 pomb 0.01183 vasculatur 0.00861 cytokinesi 0.01163 format 0.00857 bud 0.01158 mvd 0.00818 kinetochor 0.01034 Vascular Endothelial Growth Factor A 0.11426 Mitosis 0.06872 Neovascularization, Pathologic 0.11101 Microtubules 0.04485 Endothelial Cells 0.06742 Cell Cycle Proteins 0.04087 Endothelium, Vascular 0.06550 Mitotic Spindle Apparatus 0.04002 Humans 0.04479 Animals 0.03106 Angiogenesis Inhibitors 0.04160 Meiosis 0.03074 Neovascularization, Physiologic 0.03503 Schizosaccharomyces 0.02818 Vascular Endothelial Growth Factor Receptor-2 0.02108 Chromosome Segregation 0.01992 Animals 0.02102 Cell Division 0.01927 Umbilical Veins 0.01901 Microtubule-Associated Proteins 0.01883 Cells, Cultured 0.01764 Nuclear Proteins 0.01855 Cell Movement 0.01266 Saccharomyces cerevisiae Proteins 0.01839 Microcirculation 0.01211 Schizosaccharomyces pombe Proteins 0.01828 Fibroblast Growth Factor 2 0.01065 Tubulin 0.01732 Endostatins 0.00930 Centrosome 0.01636 Cell Proliferation 0.00877 Cell Cycle 0.01608 Blood Vessels 0.00873 Kinetochores 0.01560 Receptors, Vascular Endothelial Growth Factor 0.00838 Protein-Serine-Threonine Kinases 0.01479 Vascular Endothelial Growth Factor Receptor-1 0.00838 Cytokinesis 0.01446 Antigens, CD 0.00786 Saccharomyces cerevisiae 0.01350 TOPIC 59 0.00497 TOPIC 60 0.00495 map 0.11272 therapi 0.17769 linkag 0.06292 clinic 0.13057 locu 0.05955 treatment 0.07236 chromosom 0.05484 therapeut 0.04177 loci 0.05478 agent 0.03850 marker 0.04435 trial 0.03587 qtl 0.03785 improv 0.02922 iron 0.03329 current 0.02385 trait 0.02842 efficaci 0.01740 analysi 0.02062 approach 0.01727 region 0.02025 promis 0.01552 quantit 0.01952 strategi 0.01482 genet 0.01838 benefit 0.01455 identifi 0.01739 manag 0.01387 candid 0.01220 advanc 0.01380 lod 0.01219 drug 0.01102 genom 0.01209 option 0.01048 scan 0.01099 futur 0.01042 genome-wid 0.01061 need 0.01038 microsatellit 0.01052 new 0.00957 Chromosome Mapping 0.12674 Humans 0.29966 Quantitative Trait Loci 0.07009 Antineoplastic Agents 0.05368 Linkage (Genetics) 0.06912 Clinical Trials 0.04739 Genetic Markers 0.04358 Treatment Outcome 0.03937 Microsatellite Repeats 0.03407 Neoplasms 0.03647 Humans 0.02891 Gene Therapy 0.03308 Phenotype 0.02858 Animals 0.01932 Lod Score 0.02814 Combined Modality Therapy 0.01349 Genotype 0.02706 Antibodies, Monoclonal 0.01247 Genetic Predisposition to Disease 0.02306 Prognosis 0.01097 Iron 0.02152 Drug Therapy, Combination 0.00744 Crosses, Genetic 0.01891 Risk Assessment 0.00731 Hemochromatosis 0.01790 Randomized Controlled Trials 0.00631 Genome, Human 0.01591 Immunotherapy 0.00521 Pedigree 0.01562 Drug Delivery Systems 0.00492 Membrane Proteins 0.01291 Medical Oncology 0.00459 Animals 0.01128 Forecasting 0.00432 Histocompatibility Antigens Class I 0.01026 Clinical Trials, Phase I 0.00417 Models, Genetic 0.00925 Drug Administration Schedule 0.00414 Genome 0.00856 Time Factors 0.00383 TOPIC 61 0.00491 TOPIC 62 0.00484 signal 0.33476 organ 0.14946 pathwai 0.21187 drosophila 0.10642 transduct 0.03858 function 0.04681 regul 0.03197 conserv 0.03552 activ 0.02833 elegan 0.03540 involv 0.02153 melanogast 0.02840 downstream 0.01934 mammalian 0.02420 mediat 0.01898 develop 0.02021 intracellular 0.01823 homolog 0.01905 compon 0.01367 caenorhabd 0.01805 molecul 0.01317 vertebr 0.01546 cascad 0.01233 requir 0.01404 transduc 0.01121 anim 0.01388 target 0.01026 act 0.01289 requir 0.00965 suggest 0.01273 stat 0.00953 development 0.01225 lead 0.00916 homologu 0.01182 cellular 0.00914 wing 0.01173 kei 0.00856 mammal 0.01160 mechan 0.00845 essenti 0.01157 Signal Transduction 0.34787 Animals 0.15808 Animals 0.06314 Drosophila Proteins 0.10736 Trans-Activators 0.04832 Drosophila melanogaster 0.09423 DNA-Binding Proteins 0.04121 Drosophila 0.08434 Humans 0.03050 Caenorhabditis elegans 0.05354 Mice 0.01734 Caenorhabditis elegans Proteins 0.03304 Models, Biological 0.01640 Gene Expression Regulation, Developmental 0.02636 Transcription Factors 0.01209 Genes, Insect 0.02064 Proto-Oncogene Proteins 0.01008 Animals, Genetically Modified 0.01801 STAT5 Transcription Factor 0.00968 Amino Acid Sequence 0.01383 Milk Proteins 0.00921 Wing 0.01179 Intracellular Signaling Peptides and Proteins 0.00846 Larva 0.01129 Receptors, Cell Surface 0.00788 Molecular Sequence Data 0.01075 Gene Expression Regulation 0.00736 Models, Biological 0.01021 STAT3 Transcription Factor 0.00723 Sequence Homology, Amino Acid 0.01000 Membrane Proteins 0.00709 Mutation 0.00903 Repressor Proteins 0.00625 Embryo, Nonmammalian 0.00713 Mutation 0.00625 RNA Interference 0.00656 Cell Line 0.00578 Phenotype 0.00613 Adaptor Proteins, Signal Transducing 0.00518 Genes, Helminth 0.00534 TOPIC 63 0.00476 TOPIC 64 0.00473 risk 0.36292 radiat 0.14601 factor 0.13385 irradi 0.09503 increas 0.04750 dose 0.08211 associ 0.04302 effect 0.03118 studi 0.02681 exposur 0.02511 case 0.02517 radiotherapi 0.02114 diseas 0.02317 radiation-induc 0.01876 develop 0.02084 radiosensit 0.01849 rel 0.01808 ioniz 0.01760 assess 0.01642 expos 0.01439 histori 0.01559 x-rai 0.01429 epidemiolog 0.01347 fraction 0.01407 cardiovascular 0.01301 ion 0.01361 high-risk 0.01265 energi 0.01199 case-control 0.01165 beam 0.01171 individu 0.01043 gamma 0.01164 incid 0.01018 rai 0.00942 cohort 0.00714 damag 0.00836 identifi 0.00666 particl 0.00828 high 0.00640 biolog 0.00819 Risk Factors 0.25410 Radiation Dosage 0.07286 Humans 0.09973 Dose-Response Relationship, Radiation 0.06948 Risk Assessment 0.05572 Gamma Rays 0.04002 Case-Control Studies 0.05022 Radiation Tolerance 0.03551 Middle Aged 0.04755 Humans 0.03402 Adult 0.04541 Radiation Injuries 0.03064 Genetic Predisposition to Disease 0.03281 Radiotherapy Dosage 0.02260 Aged 0.02970 Linear Energy Transfer 0.02179 Risk 0.02625 Radiation Protection 0.02121 Cardiovascular Diseases 0.01645 Neoplasms, Radiation-Induced 0.02090 Cohort Studies 0.01498 Radiation, Ionizing 0.01931 Incidence 0.01452 Radiometry 0.01824 Odds Ratio 0.00860 Radiotherapy 0.01687 Prospective Studies 0.00651 X-Rays 0.01571 Smoking 0.00568 Heavy Ions 0.01520 Life Style 0.00564 Relative Biological Effectiveness 0.01312 Prevalence 0.00453 Radiation-Protective Agents 0.01309 Logistic Models 0.00412 Radiation-Sensitizing Agents 0.01302 Aged, 80 and over 0.00403 Radiation Monitoring 0.01231 Age Factors 0.00384 Cell Survival 0.01001 TOPIC 65 0.00450 TOPIC 66 0.00445 tumor 0.72447 rna 0.27003 malign 0.03712 sirna 0.06136 carcinoma 0.01906 interfer 0.05180 suppressor 0.01904 small 0.04858 solid 0.01821 silenc 0.04158 tumorigenesi 0.01703 interf 0.03598 progress 0.01362 rnai 0.03147 loh 0.01085 target 0.02718 wt1 0.00849 knockdown 0.01598 intratumor 0.00719 rnase 0.01577 wilm 0.00675 short 0.01424 neoplasm 0.00616 specif 0.01335 frequent 0.00586 polymeras 0.01313 medulloblastoma 0.00534 ribozym 0.01274 tumor-specif 0.00505 function 0.01265 tumor-associ 0.00498 vitro 0.01034 heterozygos 0.00484 transcript 0.00939 tumorigen 0.00423 double-strand 0.00827 oncogen 0.00416 dsrna 0.00825 loss 0.00399 inhibit 0.00811 Humans 0.16647 RNA, Small Interfering 0.15899 Neoplasms 0.08187 RNA Interference 0.13294 Cell Line, Tumor 0.04396 Gene Silencing 0.05712 Gene Expression Regulation, Neoplastic 0.03981 RNA 0.05264 Immunohistochemistry 0.02882 Base Sequence 0.03972 Genes, Tumor Suppressor 0.02699 Animals 0.02469 Loss of Heterozygosity 0.02497 RNA, Messenger 0.01922 Tumor Markers, Biological 0.01975 RNA, Double-Stranded 0.01693 Tumor Cells, Cultured 0.01760 Transfection 0.01651 Tumor Suppressor Proteins 0.01724 Transcription, Genetic 0.01392 Cell Transformation, Neoplastic 0.01694 Nucleic Acid Conformation 0.01380 Disease Progression 0.01536 Hela Cells 0.01328 Brain Neoplasms 0.01173 RNA, Catalytic 0.01259 Neoplasm Transplantation 0.01160 Humans 0.01205 Adenocarcinoma 0.01119 Cell Line 0.01141 DNA, Neoplasm 0.01017 Molecular Sequence Data 0.01028 Kidney Neoplasms 0.00836 DNA-Directed RNA Polymerases 0.00892 Mammary Neoplasms, Experimental 0.00836 RNA Polymerase II 0.00855 Aged 0.00763 RNA, Viral 0.00848 Neoplasm Staging 0.00751 Ribonuclease III 0.00843 TOPIC 67 0.00443 TOPIC 68 0.00442 isol 0.20960 dog 0.04577 strain 0.19111 anim 0.04285 sequenc 0.02984 bovin 0.03998 tuberculosi 0.02326 pig 0.03556 type 0.01538 breed 0.02880 mycobacterium 0.01513 milk 0.02715 analysi 0.01122 cat 0.02479 serotyp 0.01012 cattl 0.02184 16s 0.01002 cow 0.02116 rrna 0.00997 porcin 0.02081 character 0.00988 sheep 0.01906 speci 0.00926 canin 0.01816 belong 0.00898 prion 0.01650 divers 0.00874 prp 0.01582 ident 0.00783 product 0.01473 outbreak 0.00760 domest 0.01219 phylogenet 0.00741 calv 0.01131 identifi 0.00698 goat 0.01092 epidemiolog 0.00694 herd 0.01070 nov 0.00676 hors 0.01063 Molecular Sequence Data 0.05521 Animals 0.23805 Sequence Analysis, DNA 0.04772 Cattle 0.10842 Phylogeny 0.04742 Dogs 0.05990 DNA, Bacterial 0.04341 Swine 0.05769 Bacterial Typing Techniques 0.02956 Sheep 0.02690 Mycobacterium tuberculosis 0.02771 Dog Diseases 0.02209 RNA, Ribosomal, 16S 0.02766 Breeding 0.02052 Bacterial Proteins 0.02615 Cats 0.01747 Humans 0.02377 Prions 0.01732 Variation (Genetics) 0.02157 Horses 0.01668 Polymerase Chain Reaction 0.02038 Lactation 0.01397 Species Specificity 0.01873 Milk 0.01290 Base Sequence 0.01687 Cattle Diseases 0.01258 Animals 0.01529 Goats 0.00953 DNA, Ribosomal 0.01390 Sus scrofa 0.00854 Genes, rRNA 0.01131 Species Specificity 0.00774 Genotype 0.01126 Animals, Newborn 0.00625 Serotyping 0.01103 Dairying 0.00618 Disease Outbreaks 0.01098 Pregnancy 0.00610 Tuberculosis 0.01064 Cat Diseases 0.00571 TOPIC 69 0.00440 TOPIC 70 0.00435 liver 0.20656 coli 0.09677 hepat 0.12419 escherichia 0.05618 hcc 0.06341 plasmid 0.05002 hepatocyt 0.04679 strain 0.04676 hcv 0.03937 bacteri 0.02116 hepatocellular 0.03880 recombin 0.02009 hbv 0.03534 operon 0.02002 chronic 0.02325 bacillu 0.01989 carcinoma 0.02205 phage 0.01959 viru 0.01892 bacteria 0.01765 cirrhosi 0.01719 product 0.01722 hepatoma 0.01405 encod 0.01366 hepg2 0.01352 purifi 0.01128 fibrosi 0.01104 contain 0.01068 aim 0.00963 produc 0.01046 afp 0.00881 transfer 0.00936 portal 0.00867 sigma 0.00904 methods 0.00847 construct 0.00897 infect 0.00821 subtili 0.00895 hepatocarcinogenesi 0.00656 bacteriophag 0.00729 Liver Neoplasms 0.13351 Escherichia coli 0.15761 Liver 0.13110 Bacterial Proteins 0.07113 Carcinoma, Hepatocellular 0.10855 Plasmids 0.06277 Hepatocytes 0.05561 Escherichia coli Proteins 0.05736 Hepatitis B virus 0.03768 Gene Expression Regulation, Bacterial 0.04758 Hepacivirus 0.03490 DNA, Bacterial 0.04338 Liver Cirrhosis 0.02653 Genes, Bacterial 0.02113 Hepatitis C 0.02380 Recombinant Proteins 0.02013 Hepatitis C, Chronic 0.02173 Molecular Sequence Data 0.01867 Hepatitis B 0.02083 Operon 0.01557 Hepatitis B, Chronic 0.01884 Bacillus subtilis 0.01411 Antiviral Agents 0.01409 Cloning, Molecular 0.01370 DNA, Viral 0.01347 Chromosomes, Bacterial 0.01320 Liver Diseases 0.01205 Base Sequence 0.00919 Humans 0.01093 Lactobacillus 0.00668 Hepatitis B Surface Antigens 0.01035 Culture Media 0.00647 Fatty Liver 0.00864 Pichia 0.00569 Liver Transplantation 0.00804 RNA, Bacterial 0.00547 Alanine Transaminase 0.00762 Bacterial Toxins 0.00544 Lamivudine 0.00687 Bacteriophages 0.00534 TOPIC 71 0.00433 TOPIC 72 0.00429 express 0.76252 embryo 0.08940 gene 0.03999 oocyt 0.06219 expression 0.03008 transfer 0.03251 upregul 0.02836 matur 0.02983 downregul 0.02136 fertil 0.02664 pattern 0.01459 cycl 0.02456 tissu 0.01185 pregnanc 0.02384 correl 0.01065 reproduct 0.02257 differenti 0.00997 rate 0.01942 coexpress 0.00691 ivf 0.01925 highli 0.00639 blastocyst 0.01916 immunohistochemistri 0.00627 follicl 0.01821 transcript 0.00531 vitro 0.01698 co-express 0.00514 develop 0.01517 regul 0.00331 assist 0.01429 tissue-specif 0.00325 fsh 0.01127 ubiquit 0.00246 art 0.01014 dysregul 0.00223 ovari 0.00988 weakli 0.00164 ovul 0.00970 profil 0.00152 stage 0.00959 Gene Expression 0.07652 Pregnancy 0.07370 Reverse Transcriptase Polymerase Chain Reaction 0.06754 Oocytes 0.06680 Immunohistochemistry 0.06632 Fertilization in Vitro 0.06356 RNA, Messenger 0.06627 Embryo Transfer 0.03518 Gene Expression Regulation 0.06455 Animals 0.03441 Gene Expression Profiling 0.04818 Blastocyst 0.03048 Gene Expression Regulation, Neoplastic 0.04512 Humans 0.02537 Up-Regulation 0.03525 Embryonic Development 0.02078 Humans 0.03353 Embryo 0.02009 Down-Regulation 0.02642 Reproductive Techniques, Assisted 0.01983 Blotting, Western 0.01475 Ovary 0.01812 Animals 0.01387 Sperm Injections, Intracytoplasmic 0.01810 Transcription Factors 0.01263 Ovarian Follicle 0.01784 Gene Expression Regulation, Developmental 0.01149 Pregnancy Rate 0.01761 Neoplasm Proteins 0.01088 Infertility, Female 0.01664 Base Sequence 0.01038 Cryopreservation 0.01537 DNA Primers 0.00954 Ovulation Induction 0.01521 DNA-Binding Proteins 0.00827 Pregnancy Outcome 0.01332 Mice 0.00797 Follicle Stimulating Hormone 0.01169 Oligonucleotide Array Sequence Analysis 0.00678 Cloning, Organism 0.01141 TOPIC 73 0.00427 TOPIC 74 0.00422 lymphoma 0.15646 inhibit 0.30928 b-cell 0.05270 inhibitor 0.11526 lymphocyt 0.02915 effect 0.09890 larg 0.02426 activ 0.06942 non-hodgkin 0.02286 block 0.04903 case 0.02203 inhibitori 0.04789 cll 0.02140 suppress 0.02005 nhl 0.02110 potent 0.01960 malign 0.01995 manner 0.01666 diffus 0.01778 mechan 0.01561 rituximab 0.01702 dose-depend 0.01461 hodgkin 0.01595 prevent 0.01398 lymphoid 0.01305 decreas 0.01342 immunoglobulin 0.01298 induc 0.01293 leukemia 0.01185 vitro 0.01199 follicular 0.01139 reduc 0.00982 igh 0.01038 action 0.00852 dlbcl 0.01015 antiprolif 0.00754 rearrang 0.01007 assai 0.00580 center 0.00925 exert 0.00571 Humans 0.06585 Humans 0.11975 Lymphoma, B-Cell 0.05769 Animals 0.09705 B-Lymphocytes 0.04899 Enzyme Inhibitors 0.07683 Lymphoma, Non-Hodgkin 0.04548 Dose-Response Relationship, Drug 0.07649 Lymphoma 0.03809 Cell Line, Tumor 0.05194 Hodgkin Disease 0.02804 Cell Proliferation 0.03099 Aged 0.02373 Cell Line 0.02431 Middle Aged 0.02270 Mice 0.02267 Immunoglobulin Heavy Chains 0.02132 Time Factors 0.01903 Antibodies, Monoclonal 0.01921 Antineoplastic Agents 0.01841 Leukemia, Lymphocytic, Chronic 0.01839 Cells, Cultured 0.01804 Lymphoma, Large-Cell, Diffuse 0.01611 Down-Regulation 0.00944 Aged, 80 and over 0.01508 Blotting, Western 0.00767 Lymphoma, Follicular 0.01416 Cell Division 0.00731 Antigens, CD 0.01306 Apoptosis 0.00608 Immunophenotyping 0.01213 Rats 0.00528 Antigens, CD20 0.01185 Tumor Cells, Cultured 0.00510 Translocation, Genetic 0.01157 Thiazoles 0.00395 Adult 0.01072 Enzyme Activation 0.00382 Lymphoma, Mantle-Cell 0.01062 Transfection 0.00322 TOPIC 75 0.00418 TOPIC 76 0.00418 transplant 0.15096 water 0.04261 donor 0.07600 soil 0.03166 recipi 0.04086 commun 0.02324 graft 0.03387 contamin 0.01992 stem 0.03047 speci 0.01900 allogen 0.02929 environ 0.01769 reject 0.02422 environment 0.01538 autolog 0.01874 organ 0.01435 cell 0.01618 marin 0.01188 immunosuppress 0.01367 microbi 0.01172 allograft 0.01300 sediment 0.01169 marrow 0.01298 season 0.01145 surviv 0.01226 forest 0.01120 hematopoiet 0.01146 natur 0.01103 condit 0.01114 ecolog 0.01015 receiv 0.01026 divers 0.00991 acut 0.00997 river 0.00915 gvhd 0.00954 sourc 0.00913 engraft 0.00936 area 0.00878 diseas 0.00915 site 0.00867 Transplantation, Homologous 0.06495 Animals 0.05069 Hematopoietic Stem Cell Transplantation 0.06146 Ecosystem 0.04717 Humans 0.04553 Environmental Monitoring 0.03440 Immunosuppressive Agents 0.03397 Seasons 0.02191 Stem Cell Transplantation 0.03179 Fresh Water 0.01739 Bone Marrow Transplantation 0.03166 Water Pollutants, Chemical 0.01637 Graft vs Host Disease 0.02970 Soil Microbiology 0.01582 Kidney Transplantation 0.02904 Bacteria 0.01519 Transplantation, Autologous 0.02616 Environment 0.01464 Graft Rejection 0.02579 Conservation of Natural Resources 0.01446 Graft Survival 0.02566 Seawater 0.01359 Transplantation Conditioning 0.02477 Soil 0.01299 Tissue Donors 0.02414 Anthozoa 0.01238 Treatment Outcome 0.01625 Time Factors 0.01228 Liver Transplantation 0.01339 Geologic Sediments 0.01178 Histocompatibility Testing 0.01337 Trees 0.01126 Cyclosporine 0.01295 Water Supply 0.01102 Transplantation Chimera 0.01271 Biodiversity 0.01063 Peripheral Blood Stem Cell Transplantation 0.01206 Water 0.01044 Adult 0.01082 Water Microbiology 0.00984 TOPIC 77 0.00417 TOPIC 78 0.00415 estim 0.08561 retin 0.08185 data 0.05274 visual 0.03938 model 0.04516 optic 0.03123 method 0.04044 retina 0.03117 error 0.02645 degener 0.02982 distribut 0.01871 macular 0.02923 simul 0.01801 cone 0.01877 paramet 0.01795 photoreceptor 0.01770 statist 0.01765 pigment 0.01695 base 0.01623 amd 0.01501 power 0.01550 rod 0.01488 probabl 0.01541 age-rel 0.01454 bia 0.01504 detach 0.01430 approach 0.01502 vision 0.01366 calcul 0.01418 thick 0.01308 propos 0.01181 rpe 0.01235 likelihood 0.01156 methods 0.01185 set 0.01039 choroid 0.01113 bayesian 0.00886 examin 0.01067 assumpt 0.00781 acuiti 0.01046 Humans 0.09509 Retina 0.05774 Models, Statistical 0.08047 Humans 0.05344 Computer Simulation 0.05981 Visual Acuity 0.03377 Models, Genetic 0.05881 Macular Degeneration 0.03372 Algorithms 0.03938 Fluorescein Angiography 0.02622 Data Interpretation, Statistical 0.03712 Electroretinography 0.02450 Bayes Theorem 0.03105 Eye Proteins 0.02379 Likelihood Functions 0.02984 Pigment Epithelium of Eye 0.02242 Monte Carlo Method 0.02450 Aged 0.02096 Reproducibility of Results 0.02279 Tomography, Optical Coherence 0.01983 Sensitivity and Specificity 0.02030 Retinal Diseases 0.01983 Models, Biological 0.01895 Middle Aged 0.01901 Regression Analysis 0.01651 Retinal Degeneration 0.01761 Sample Size 0.01341 Visual Fields 0.01613 Research Design 0.01322 Retinal Ganglion Cells 0.01518 Probability 0.01251 Retinitis Pigmentosa 0.01370 Models, Theoretical 0.01209 Vision Disorders 0.01347 Markov Chains 0.01170 Cones (Retina) 0.01191 Biometry 0.01094 Retinal Detachment 0.01178 Linear Models 0.00904 Aged, 80 and over 0.01125 TOPIC 79 0.00415 TOPIC 80 0.00413 cancer 0.80560 algorithm 0.04539 bladder 0.04122 method 0.04231 tumor 0.02008 problem 0.02635 malign 0.01376 approach 0.02491 progress 0.01241 propos 0.02351 carcinogenesi 0.01225 set 0.02174 advanc 0.00996 network 0.02131 develop 0.00596 data 0.02020 type 0.00571 optim 0.01970 frequent 0.00505 base 0.01695 potenti 0.00460 comput 0.01423 cancer-rel 0.00446 paper 0.01389 superfici 0.00322 linear 0.00833 tumorigenesi 0.00318 learn 0.00824 transit 0.00262 distanc 0.00811 biomark 0.00240 gener 0.00805 deregul 0.00239 space 0.00799 carcinogen 0.00220 order 0.00794 cancer-associ 0.00199 align 0.00731 cancer-specif 0.00189 solut 0.00721 Humans 0.24555 Algorithms 0.15606 Neoplasms 0.20117 Computer Simulation 0.05139 Gene Expression Regulation, Neoplastic 0.03088 Pattern Recognition, Automated 0.04236 Tumor Markers, Biological 0.02400 Artificial Intelligence 0.03931 Antineoplastic Agents 0.01872 Models, Statistical 0.03543 Adenocarcinoma 0.01731 Reproducibility of Results 0.02839 Neoplasm Staging 0.01359 Models, Genetic 0.02696 Middle Aged 0.01227 Computational Biology 0.02571 Cell Transformation, Neoplastic 0.01084 Humans 0.02260 Prognosis 0.00970 Information Storage and Retrieval 0.02234 Aged 0.00957 Cluster Analysis 0.02226 Carcinoma, Squamous Cell 0.00775 Image Interpretation, Computer-Assisted 0.02223 Risk Factors 0.00756 Signal Processing, Computer-Assisted 0.02024 Carcinoma, Transitional Cell 0.00748 Software 0.01902 Disease Progression 0.00714 Sensitivity and Specificity 0.01888 DNA, Neoplasm 0.00693 Numerical Analysis, Computer-Assisted 0.01817 Genes, Tumor Suppressor 0.00608 Models, Biological 0.01811 Colorectal Neoplasms 0.00600 Image Enhancement 0.01710 Breast Neoplasms 0.00534 Neural Networks (Computer) 0.01607 Neoplasm Proteins 0.00529 Models, Theoretical 0.00770 TOPIC 81 0.00412 TOPIC 82 0.00405 data 0.05638 disord 0.15671 databas 0.04668 schizophrenia 0.05705 avail 0.03762 studi 0.03084 tool 0.02962 bipolar 0.03040 inform 0.02287 autism 0.02887 program 0.02258 psychiatr 0.02612 annot 0.01836 symptom 0.01883 http 0.01821 depress 0.01869 softwar 0.01627 adhd 0.01742 search 0.01514 ill 0.01273 access 0.01502 affect 0.01257 provid 0.01475 dopamin 0.01136 web 0.01456 associ 0.01095 resourc 0.01349 major 0.01029 user 0.01340 mental 0.00998 set 0.01212 find 0.00902 integr 0.01092 psychosi 0.00896 www 0.01066 comt 0.00891 allow 0.00884 hyperact 0.00888 analysi 0.00766 antipsychot 0.00790 Software 0.11061 Humans 0.10137 Internet 0.06521 Schizophrenia 0.07740 User-Computer Interface 0.06154 Autistic Disorder 0.03970 Algorithms 0.05851 Bipolar Disorder 0.03932 Databases, Genetic 0.03905 Adult 0.02979 Computational Biology 0.03642 Antipsychotic Agents 0.02762 Information Storage and Retrieval 0.02929 Mental Disorders 0.02513 Database Management Systems 0.02573 Adolescent 0.02007 Databases, Protein 0.02273 Child 0.01958 Databases, Factual 0.02169 Attention Deficit Disorder with Hyperactivity 0.01920 Computer Graphics 0.02151 Psychiatric Status Rating Scales 0.01763 Humans 0.01988 Comorbidity 0.01527 Sequence Alignment 0.01699 Psychotic Disorders 0.01462 Genomics 0.01611 Diagnostic and Statistical Manual of Mental Disorders 0.01414 Chromosome Mapping 0.01555 Receptors, Dopamine D2 0.01159 Sequence Analysis, Protein 0.01552 Nerve Tissue Proteins 0.00951 Sequence Analysis, DNA 0.01462 Schizophrenic Psychology 0.00948 Databases, Nucleic Acid 0.01220 Age of Onset 0.00821 Proteins 0.01180 Catechol O-Methyltransferase 0.00815 Gene Expression Profiling 0.00965 Substance-Related Disorders 0.00810 TOPIC 83 0.00399 TOPIC 84 0.00392 patient 0.09816 dna 0.10677 clinic 0.08375 fragment 0.09967 symptom 0.07521 pcr 0.08159 sever 0.04969 sequenc 0.06419 pain 0.04188 primer 0.05196 present 0.03142 amplifi 0.04667 sign 0.02712 restrict 0.04014 diagnosi 0.02463 amplif 0.03536 acut 0.01811 analysi 0.02628 manifest 0.01781 length 0.02219 symptomat 0.01556 polymorph 0.02108 fever 0.01538 product 0.02066 complic 0.01256 genom 0.01930 episod 0.01191 detect 0.01929 caus 0.01074 design 0.01290 asymptomat 0.01067 identif 0.01286 cours 0.01050 digest 0.01086 attack 0.01007 singl 0.01058 histori 0.01001 band 0.01035 frequent 0.00962 base 0.01024 Humans 0.18767 Polymerase Chain Reaction 0.20696 Adult 0.07537 DNA Primers 0.07904 Middle Aged 0.04147 Base Sequence 0.06540 Adolescent 0.03208 Polymorphism, Restriction Fragment Length 0.05872 Diagnosis, Differential 0.02613 Sequence Analysis, DNA 0.04311 Severity of Illness Index 0.02245 Molecular Sequence Data 0.03635 Pain 0.01993 DNA 0.03612 Aged 0.01965 Random Amplified Polymorphic DNA Technique 0.01865 Child 0.01767 Nucleic Acid Amplification Techniques 0.01627 Acute Disease 0.01551 DNA Fingerprinting 0.01485 Familial Mediterranean Fever 0.00963 Humans 0.01074 Treatment Outcome 0.00845 DNA, Bacterial 0.00900 Infant 0.00727 Restriction Mapping 0.00886 Age of Onset 0.00653 Polymorphism, Genetic 0.00850 Child, Preschool 0.00650 Animals 0.00816 Migraine Disorders 0.00609 Polymorphism, Single-Stranded Conformational 0.00707 Follow-Up Studies 0.00601 Sensitivity and Specificity 0.00679 Pain Measurement 0.00593 Genetic Markers 0.00601 Magnetic Resonance Imaging 0.00568 Gene Amplification 0.00548 Headache 0.00546 Blotting, Southern 0.00517 TOPIC 85 0.00389 TOPIC 86 0.00386 cell 0.14934 technolog 0.05143 transfect 0.13001 develop 0.04112 express 0.10333 applic 0.03715 plasmid 0.05172 new 0.03246 construct 0.05131 research 0.03057 gene 0.04478 approach 0.03037 transient 0.03213 tool 0.02108 vector 0.02882 challeng 0.01976 effici 0.01824 genom 0.01579 stabl 0.01815 discoveri 0.01530 report 0.01783 provid 0.01530 stabli 0.01740 biologi 0.01457 luciferas 0.01560 improv 0.01375 contain 0.01190 system 0.01358 clone 0.01182 advanc 0.01345 electropor 0.01124 biolog 0.01325 line 0.01118 engin 0.01311 promot 0.01014 strategi 0.01267 cdna 0.00941 field 0.01147 assai 0.00921 promis 0.01050 Transfection 0.20462 Humans 0.19052 Plasmids 0.08824 Animals 0.09963 Cell Line 0.03972 Genomics 0.03092 Genetic Vectors 0.03699 Proteomics 0.02150 Cell Line, Tumor 0.03178 Genetic Engineering 0.01546 Animals 0.02775 Biotechnology 0.01384 Genes, Reporter 0.02505 Neoplasms 0.01333 Humans 0.01916 United States 0.01143 Gene Expression 0.01843 Drug Design 0.01086 Recombinant Proteins 0.01710 Pharmacogenetics 0.00939 COS Cells 0.01657 Research 0.00851 Luciferases 0.01617 Models, Biological 0.00769 Electroporation 0.01583 Forecasting 0.00709 Cells, Cultured 0.01296 Computational Biology 0.00695 Cercopithecus aethiops 0.01180 Genetic Techniques 0.00633 Mice 0.01133 Genome, Human 0.00556 DNA, Complementary 0.01079 Molecular Biology 0.00533 Blotting, Western 0.00958 Gene Therapy 0.00530 Promoter Regions (Genetics) 0.00958 Proteome 0.00528 Green Fluorescent Proteins 0.00887 Biomedical Research 0.00491 TOPIC 87 0.00382 TOPIC 88 0.00381 express 0.32407 dna 0.46626 cell 0.20434 replic 0.10113 down-regul 0.06271 polymeras 0.02801 up-regul 0.06192 pol 0.02239 human 0.05866 helicas 0.01817 overexpress 0.03271 synthesi 0.01471 protein 0.03254 strand 0.01441 survivin 0.03049 origin 0.01276 line 0.02425 fork 0.01065 level 0.01639 genom 0.01044 ectop 0.01355 single-strand 0.00945 expression 0.01075 blm 0.00700 furthermor 0.00982 initi 0.00651 over-express 0.00972 nucleas 0.00639 suppress 0.00875 process 0.00586 decreas 0.00724 supercoil 0.00554 interestingli 0.00464 eukaryot 0.00549 induc 0.00406 stall 0.00522 role 0.00388 intermedi 0.00512 markedli 0.00352 rpa 0.00476 Down-Regulation 0.09904 DNA 0.18484 Up-Regulation 0.09731 DNA Replication 0.09915 Cell Line, Tumor 0.06058 DNA-Binding Proteins 0.05161 Gene Expression Regulation, Neoplastic 0.05513 DNA Helicases 0.03354 Humans 0.04712 DNA-Directed DNA Polymerase 0.02618 RNA, Messenger 0.03946 DNA, Single-Stranded 0.02210 Neoplasm Proteins 0.03857 Nucleic Acid Conformation 0.02181 Reverse Transcriptase Polymerase Chain Reaction 0.03530 DNA Damage 0.01411 Transfection 0.02930 Animals 0.01273 Microtubule-Associated Proteins 0.02890 Plasmids 0.01262 Blotting, Western 0.02382 Replication Origin 0.01244 Gene Expression 0.01808 Humans 0.00977 Gene Expression Regulation 0.01647 Base Sequence 0.00925 Tumor Cells, Cultured 0.01099 Models, Genetic 0.00845 Cell Proliferation 0.00950 DNA Repair 0.00819 Gene Expression Profiling 0.00841 DNA, Superhelical 0.00670 DNA, Complementary 0.00749 Escherichia coli 0.00652 Cell Line 0.00732 DNA Primers 0.00644 Immunohistochemistry 0.00608 DNA, Viral 0.00612 Membrane Proteins 0.00560 Adenosine Triphosphate 0.00612 TOPIC 89 0.00379 TOPIC 90 0.00374 colon 0.15724 drug 0.20631 colorect 0.14010 resist 0.06293 melanoma 0.13271 agent 0.05042 cancer 0.05698 cytotox 0.03060 apc 0.04093 anticanc 0.02396 adenoma 0.03990 sensit 0.02371 malign 0.02336 doxorubicin 0.02008 polyposi 0.01818 inhibitor 0.01988 polyp 0.01756 chemotherapeut 0.01981 adenomat 0.01659 paclitaxel 0.01761 melanocyt 0.01481 treatment 0.01609 braf 0.01055 chemotherapi 0.01578 adenocarcinoma 0.01051 revers 0.01435 rectal 0.00921 multidrug 0.01420 ht-29 0.00898 mdr1 0.01416 mucosa 0.00892 topoisomeras 0.01216 develop 0.00884 toxic 0.01024 carcinogenesi 0.00884 chemosensit 0.01016 uveal 0.00883 effect 0.00992 crypt 0.00773 p-gp 0.00987 Colorectal Neoplasms 0.15869 Antineoplastic Agents 0.09904 Colonic Neoplasms 0.12645 Drug Resistance, Neoplasm 0.08537 Melanoma 0.11829 Humans 0.07073 Skin Neoplasms 0.05190 Doxorubicin 0.04242 Humans 0.04528 P-Glycoprotein 0.03479 Adenoma 0.03149 Drug Resistance, Multiple 0.03227 Colon 0.02484 Paclitaxel 0.02989 Adenomatous Polyposis Coli 0.02125 Antineoplastic Agents, Phytogenic 0.02813 Adenocarcinoma 0.02122 Antibiotics, Antineoplastic 0.01960 Intestinal Mucosa 0.01735 Etoposide 0.01517 Colonoscopy 0.01313 Drug Screening Assays, Antitumor 0.01308 Genes, APC 0.01246 Genes, MDR 0.01217 Melanocytes 0.01116 Reverse Transcriptase Inhibitors 0.01165 Middle Aged 0.00928 Multidrug Resistance-Associated Proteins 0.00959 Aged 0.00789 Drug Interactions 0.00953 Rectal Neoplasms 0.00755 Tumor Cells, Cultured 0.00906 Colonic Polyps 0.00714 Camptothecin 0.00877 Cell Transformation, Neoplastic 0.00648 Cell Line, Tumor 0.00857 Uveal Neoplasms 0.00622 Fluorouracil 0.00821 Proto-Oncogene Proteins B-raf 0.00593 Neoplasms 0.00816 TOPIC 91 0.00368 TOPIC 92 0.00363 mrna 0.09318 corneal 0.03685 translat 0.08994 len 0.03190 antisens 0.04546 cataract 0.03133 rna 0.03399 visual 0.03005 initi 0.02641 glaucoma 0.02792 ribosom 0.02570 ocular 0.02600 protein 0.02273 methods 0.01865 transcript 0.01847 conclusions 0.01589 oligonucleotid 0.01649 cornea 0.01449 utr 0.01619 surgeri 0.01425 mirna 0.01591 examin 0.01376 regul 0.01569 aberr 0.01357 termin 0.01522 intraocular 0.01272 eukaryot 0.01493 acuiti 0.01260 synthesi 0.01390 refract 0.01185 sens 0.01367 mean 0.01151 codon 0.01360 iop 0.01136 stabil 0.01138 anterior 0.01088 poli 0.01105 perform 0.01059 decai 0.01099 myopia 0.00906 RNA, Messenger 0.11497 Humans 0.07222 Protein Biosynthesis 0.07374 Visual Acuity 0.04105 Base Sequence 0.04371 Cataract 0.03501 3' Untranslated Regions 0.03095 Cornea 0.02947 Molecular Sequence Data 0.03002 Middle Aged 0.02572 Oligonucleotides, Antisense 0.02982 Aged 0.02467 5' Untranslated Regions 0.02758 Glaucoma 0.02421 MicroRNAs 0.02603 Adult 0.02340 RNA-Binding Proteins 0.02451 Intraocular Pressure 0.02249 Ribosomes 0.02421 Lens, Crystalline 0.02137 Transcription, Genetic 0.02350 Lens Implantation, Intraocular 0.01787 Animals 0.02030 Aged, 80 and over 0.01590 RNA Stability 0.01914 Myopia 0.01590 Nucleic Acid Conformation 0.01431 Glaucoma, Open-Angle 0.01484 Humans 0.01369 Cataract Extraction 0.01460 RNA Processing, Post-Transcriptional 0.01166 Refraction, Ocular 0.01351 RNA, Antisense 0.01064 Postoperative Complications 0.01233 Gene Expression Regulation 0.00900 Phacoemulsification 0.01233 Saccharomyces cerevisiae Proteins 0.00829 Eye Proteins 0.01115 Ribosomal Proteins 0.00799 Lenses, Intraocular 0.01097 TOPIC 93 0.00362 TOPIC 94 0.00361 area 0.03316 lung 0.31836 countri 0.02848 pulmonari 0.06574 popul 0.02709 nsclc 0.05015 european 0.02622 respiratori 0.03690 region 0.02534 non-smal 0.02974 north 0.02178 airwai 0.02372 south 0.01895 adenocarcinoma 0.02353 europ 0.01750 alveolar 0.01475 geograph 0.01659 ventil 0.01396 northern 0.01655 a549 0.01383 africa 0.01517 non-small-cel 0.01216 southern 0.01461 small 0.01181 origin 0.01231 fibrosi 0.01175 america 0.01210 sclc 0.01171 india 0.01130 bronchial 0.01126 eastern 0.01085 copd 0.01087 central 0.01076 interstiti 0.00965 live 0.01070 compar 0.00944 world 0.01048 obstruct 0.00944 asia 0.01010 breath 0.00899 Humans 0.07932 Lung Neoplasms 0.29101 Europe 0.04300 Carcinoma, Non-Small-Cell Lung 0.12380 India 0.03556 Lung 0.09110 Geography 0.02840 Carcinoma, Small Cell 0.02377 Brazil 0.02244 Humans 0.01954 Spain 0.02132 Lung Diseases 0.01271 Italy 0.01793 Adenocarcinoma 0.01249 Prevalence 0.01567 Pulmonary Disease, Chronic Obstructive 0.01152 Demography 0.01515 Respiratory Function Tests 0.00954 Russia 0.01406 Pulmonary Alveoli 0.00918 Haplotypes 0.01376 Cystic Fibrosis 0.00848 Africa 0.01364 Pulmonary Fibrosis 0.00824 Phylogeny 0.01276 Bronchi 0.00778 Genetics, Population 0.01255 Respiration, Artificial 0.00702 Australia 0.01182 Forced Expiratory Volume 0.00690 Population Dynamics 0.01167 Smoking 0.00684 Animals 0.01089 Bronchoalveolar Lavage Fluid 0.00681 Asia 0.01004 Respiratory Mucosa 0.00517 Emigration and Immigration 0.00971 Aged 0.00511 South Africa 0.00814 Hypertension, Pulmonary 0.00432 TOPIC 95 0.00360 TOPIC 96 0.00358 splice 0.12774 cognit 0.03687 exon 0.10082 memori 0.03673 altern 0.09807 movement 0.03314 isoform 0.08204 learn 0.03291 intron 0.07210 task 0.03277 site 0.03214 perform 0.03150 transcript 0.02491 impair 0.02361 gene 0.02086 deficit 0.01850 encod 0.01672 motor 0.01689 variant 0.01640 process 0.01492 identifi 0.01488 visual 0.01419 novel 0.01480 spatial 0.01411 sequenc 0.01465 test 0.01373 human 0.01342 languag 0.01309 protein 0.01330 attent 0.01296 lack 0.01261 behavior 0.01246 function 0.01020 particip 0.01203 report 0.01007 abil 0.01200 pre-mrna 0.00966 word 0.01194 reveal 0.00816 object 0.01089 Alternative Splicing 0.12262 Humans 0.07963 Exons 0.11170 Adult 0.03951 Protein Isoforms 0.09277 Neuropsychological Tests 0.03295 Introns 0.08465 Cognition Disorders 0.03142 RNA Splicing 0.04433 Cognition 0.02989 Base Sequence 0.03444 Memory 0.02747 RNA, Messenger 0.03377 Reaction Time 0.02465 Molecular Sequence Data 0.03213 Psychomotor Performance 0.02282 Reverse Transcriptase Polymerase Chain Reaction 0.01753 Attention 0.01908 Humans 0.01631 Visual Perception 0.01810 RNA Precursors 0.01421 Photic Stimulation 0.01642 RNA Splice Sites 0.01387 Analysis of Variance 0.01596 RNA-Binding Proteins 0.00977 Learning 0.01345 Spliceosomes 0.00943 Behavior, Animal 0.01136 Mice 0.00922 Space Perception 0.01093 DNA, Complementary 0.00825 Cues 0.01075 Hela Cells 0.00718 Brain 0.01060 Isoenzymes 0.00654 Movement 0.01038 Amino Acid Sequence 0.00581 Brain Mapping 0.00882 Models, Genetic 0.00536 Memory Disorders 0.00802 TOPIC 97 0.00356 TOPIC 98 0.00348 stain 0.07199 heart 0.10522 case 0.04203 cardiac 0.09592 biopsi 0.03993 left 0.04328 immunohistochem 0.03923 ventricular 0.03585 sarcoma 0.03561 failur 0.03320 tissu 0.03197 right 0.02372 posit 0.02555 cardiomyopathi 0.01966 specimen 0.02421 cardiomyocyt 0.01890 histolog 0.02387 hypertrophi 0.01488 section 0.02187 atrial 0.01436 immunohistochemistri 0.01761 valv 0.01265 immunostain 0.01358 dilat 0.01126 malign 0.01316 sudden 0.01094 immunoreact 0.01275 myocyt 0.01079 soft 0.01268 myocardi 0.01023 stromal 0.01098 ecg 0.00987 marker 0.01052 cardiovascular 0.00965 neg 0.00998 caus 0.00958 neoplasm 0.00927 hypertroph 0.00952 benign 0.00805 death 0.00873 Immunohistochemistry 0.16608 Myocardium 0.05613 Humans 0.07994 Humans 0.04848 Tumor Markers, Biological 0.04981 Electrocardiography 0.04199 Adult 0.04784 Myocytes, Cardiac 0.04095 Aged 0.04248 Heart 0.03323 Middle Aged 0.03959 Echocardiography 0.02429 Sarcoma 0.02546 Heart Failure, Congestive 0.02353 Diagnosis, Differential 0.02346 Heart Ventricles 0.02205 Biopsy 0.02263 Heart Rate 0.02139 Aged, 80 and over 0.01789 Cardiomyopathy, Dilated 0.01471 Immunoenzyme Techniques 0.01607 Heart Defects, Congenital 0.01433 Soft Tissue Neoplasms 0.01428 Cardiomyopathies 0.01424 Adolescent 0.01305 Long QT Syndrome 0.01421 Biopsy, Fine-Needle 0.01231 Arrhythmia 0.01364 Sarcoma, Ewing's 0.01090 Heart Diseases 0.01238 Biopsy, Needle 0.00979 Myocardial Contraction 0.01184 Bone Neoplasms 0.00831 Death, Sudden, Cardiac 0.01027 Child 0.00662 Cardiomyopathy, Hypertrophic 0.00961 Paraffin Embedding 0.00643 Atrial Fibrillation 0.00819 Ki-67 Antigen 0.00622 Hypertrophy, Left Ventricular 0.00772 TOPIC 99 0.00347 TOPIC 100 0.00346 protein 0.88225 infect 0.18778 function 0.01567 viru 0.10055 kda 0.01447 viral 0.05154 encod 0.01238 herp 0.02772 cellular 0.01195 ebv 0.02532 abund 0.00608 simplex 0.02357 purifi 0.00552 cmv 0.02272 polypeptid 0.00545 replic 0.02035 immunoblot 0.00446 hsv-1 0.01799 proteom 0.00396 latent 0.01583 homologu 0.00308 cytomegaloviru 0.01576 lysat 0.00261 epstein-barr 0.01496 homolog 0.00223 hsv 0.01338 phosphoprotein 0.00190 herpesviru 0.01190 interestingli 0.00178 host 0.01091 post-transl 0.00168 virus 0.01026 ubiquit 0.00150 lytic 0.00899 multifunct 0.00126 antivir 0.00889 calreticulin 0.00107 cellular 0.00760 hypothet 0.00090 demonstr 0.00745 Proteins 0.09460 DNA, Viral 0.05333 Amino Acid Sequence 0.07948 Viral Proteins 0.05000 Animals 0.06506 Herpesvirus 1, Human 0.04099 Molecular Sequence Data 0.05061 Herpesvirus 4, Human 0.03978 Humans 0.04651 Virus Replication 0.03607 Carrier Proteins 0.03402 Cytomegalovirus 0.02687 Blotting, Western 0.03326 Antiviral Agents 0.02684 Recombinant Proteins 0.02310 Humans 0.02678 Membrane Proteins 0.02184 Cytomegalovirus Infections 0.02230 Electrophoresis, Polyacrylamide Gel 0.01612 Herpes Simplex 0.02097 Sequence Homology, Amino Acid 0.01382 RNA, Viral 0.01840 Cell Line 0.01130 Simplexvirus 0.01726 Protein Binding 0.00956 Gene Expression Regulation, Viral 0.01548 Recombinant Fusion Proteins 0.00865 Epstein-Barr Virus Infections 0.01542 Neoplasm Proteins 0.00789 Viral Envelope Proteins 0.01504 Protein Processing, Post-Translational 0.00754 Herpesvirus 8, Human 0.01488 Proteomics 0.00672 Herpesvirus 2, Human 0.01459 Immunoblotting 0.00669 Ganciclovir 0.01278 Molecular Weight 0.00596 Antibodies, Viral 0.01272 Sequence Alignment 0.00574 Immediate-Early Proteins 0.01253 TOPIC 101 0.00342 TOPIC 102 0.00341 behavior 0.08942 methyl 0.17282 person 0.04877 gene 0.07133 depress 0.03886 promot 0.06478 social 0.03607 dna 0.06377 behaviour 0.02673 epigenet 0.04060 psycholog 0.02025 hypermethyl 0.03111 particip 0.01767 cpg 0.02981 serotonin 0.01624 methyltransferas 0.02233 anxieti 0.01613 statu 0.01951 individu 0.01536 island 0.01940 studi 0.01408 silenc 0.01712 relat 0.01368 mgmt 0.01438 relationship 0.01364 inactiv 0.01265 emot 0.01328 rassf1a 0.01188 examin 0.01196 aberr 0.01139 trait 0.01113 associ 0.01081 cope 0.01108 suppressor 0.01024 physic 0.01072 region 0.01011 distress 0.01005 frequent 0.01001 percept 0.00921 loss 0.00981 Humans 0.06320 DNA Methylation 0.20209 Adult 0.05110 Promoter Regions (Genetics) 0.08252 Questionnaires 0.03378 CpG Islands 0.06457 Adaptation, Psychological 0.02846 Epigenesis, Genetic 0.04865 Depression 0.02664 Gene Silencing 0.03757 Anxiety 0.01982 Azacitidine 0.02765 Serotonin Plasma Membrane Transport Proteins 0.01713 Gene Expression Regulation, Neoplastic 0.01984 Behavior, Animal 0.01665 Methylation 0.01891 Stress, Psychological 0.01636 DNA (Cytosine-5-)-Methyltransferase 0.01830 Adolescent 0.01486 Genes, Tumor Suppressor 0.01544 Social Behavior 0.01425 Tumor Suppressor Proteins 0.01522 Personality 0.01367 Polymerase Chain Reaction 0.01496 Serotonin 0.01265 Humans 0.01352 Middle Aged 0.01252 Base Sequence 0.01349 Membrane Glycoproteins 0.01220 DNA Modification Methylases 0.01127 Analysis of Variance 0.01175 DNA, Neoplasm 0.01114 Psychiatric Status Rating Scales 0.01127 DNA-Binding Proteins 0.01111 Nerve Tissue Proteins 0.01089 Genomic Imprinting 0.00944 Interpersonal Relations 0.01012 O(6)-Methylguanine-DNA Methyltransferase 0.00944 Self Concept 0.00964 Methyl-CpG-Binding Protein 2 0.00893 TOPIC 103 0.00341 TOPIC 104 0.00339 arteri 0.08260 cleft 0.03715 coronari 0.04652 palat 0.02667 vascular 0.03274 facial 0.02354 stroke 0.03124 dental 0.02086 infarct 0.02760 lip 0.02081 aortic 0.02317 later 0.01796 myocardi 0.02254 teeth 0.01739 ischemia 0.02009 tooth 0.01545 ischem 0.01939 molar 0.01391 vein 0.01685 upper 0.01367 vessel 0.01505 flap 0.01310 aneurysm 0.01496 deform 0.01308 cerebr 0.01492 face 0.01204 cardiovascular 0.01481 nasal 0.01180 atherosclerosi 0.01443 cranial 0.01059 cad 0.01430 craniofaci 0.01049 chd 0.01225 perman 0.00925 carotid 0.01220 maxillari 0.00919 reperfus 0.01202 posterior 0.00875 aorta 0.01160 mandibular 0.00868 Humans 0.05852 Humans 0.09425 Myocardial Infarction 0.03980 Cleft Palate 0.03568 Cerebrovascular Accident 0.02753 Child 0.02858 Aged 0.02611 Cleft Lip 0.02812 Arteriosclerosis 0.02554 Adolescent 0.02457 Coronary Disease 0.02136 Cephalometry 0.02092 Coronary Arteriosclerosis 0.02004 Adult 0.01834 Aorta 0.01728 Mandible 0.01805 Risk Factors 0.01622 Maxilla 0.01582 Muscle, Smooth, Vascular 0.01606 Incisor 0.01547 Middle Aged 0.01567 Skull 0.01411 Stents 0.01532 Face 0.01401 Brain Ischemia 0.01391 Reconstructive Surgical Procedures 0.01337 Coronary Vessels 0.01291 Surgical Flaps 0.01256 Coronary Angiography 0.01266 Anodontia 0.00746 Aorta, Thoracic 0.00983 Molar 0.00710 Tunica Intima 0.00976 Malocclusion 0.00704 Ischemia 0.00931 Orthodontics, Corrective 0.00633 Carotid Arteries 0.00925 Treatment Outcome 0.00620 Angioplasty, Transluminal, Percutaneous Coronary 0.00922 Facial Bones 0.00607 TOPIC 105 0.00333 TOPIC 106 0.00329 wheat 0.04162 exposur 0.13398 rice 0.03887 expos 0.04452 marker 0.02331 toxic 0.03425 cultivar 0.02247 carcinogen 0.02823 maiz 0.02236 chemic 0.02767 line 0.02120 mutagen 0.02557 plant 0.01717 adduct 0.02449 diploid 0.01594 genotox 0.02421 cross 0.01531 effect 0.02219 parent 0.01526 environment 0.01364 hybrid 0.01433 air 0.01321 access 0.01361 worker 0.01288 barlei 0.01298 assess 0.01126 speci 0.01158 studi 0.01119 grain 0.01122 pah 0.01094 yield 0.01113 indic 0.01069 ssr 0.01099 occup 0.01046 wild 0.01000 biomark 0.01022 breed 0.00990 potenti 0.00995 deriv 0.00969 level 0.00981 Triticum 0.06696 Mutagens 0.05744 Oryza sativa 0.05444 Animals 0.03628 Genes, Plant 0.04416 Occupational Exposure 0.03608 DNA, Plant 0.04330 Carcinogens 0.03465 Chromosomes, Plant 0.04235 Mutagenicity Tests 0.03311 Zea mays 0.03875 Humans 0.03079 Crosses, Genetic 0.03325 Dose-Response Relationship, Drug 0.03029 Plant Diseases 0.03226 Environmental Exposure 0.02519 Genome, Plant 0.02837 Micronucleus Tests 0.02180 Plant Proteins 0.02458 DNA Adducts 0.01884 Genetic Markers 0.02369 Air Pollutants 0.01811 Hybridization, Genetic 0.02109 Environmental Monitoring 0.01408 Hordeum 0.01967 Risk Assessment 0.01311 Polyploidy 0.01872 Benzo(a)pyrene 0.01308 Seeds 0.01842 DNA Damage 0.01298 Immunity, Natural 0.01621 Biological Markers 0.01275 Species Specificity 0.01522 Environmental Pollutants 0.01208 Breeding 0.01239 Polycyclic Hydrocarbons, Aromatic 0.01142 Plants, Genetically Modified 0.01163 Micronuclei, Chromosome-Defective 0.01102 Plant Leaves 0.00966 Lymphocytes 0.01015 TOPIC 107 0.00329 TOPIC 108 0.00323 channel 0.10228 renal 0.15134 calcium 0.05369 kidnei 0.09918 ca2+ 0.03756 cerevisia 0.05595 current 0.03556 yeast 0.04814 atp 0.02595 saccharomyc 0.04717 ion 0.02273 urinari 0.04373 sodium 0.02066 urin 0.03121 intracellular 0.01974 rcc 0.02996 potenti 0.01958 failur 0.02023 releas 0.01262 tubular 0.01592 transient 0.01223 excret 0.01480 subunit 0.01177 creatinin 0.01291 potassium 0.01128 glomerular 0.01195 gate 0.01083 nephropathi 0.01140 open 0.01038 tubul 0.01054 conduct 0.00958 dialysi 0.00961 membran 0.00938 clear 0.00936 activ 0.00919 proteinuria 0.00825 blocker 0.00871 tract 0.00823 function 0.00803 polycyst 0.00780 Calcium 0.11225 Saccharomyces cerevisiae 0.13207 Animals 0.06059 Kidney 0.10709 Membrane Potentials 0.03121 Kidney Neoplasms 0.06732 Patch-Clamp Techniques 0.02854 Saccharomyces cerevisiae Proteins 0.06226 Adenosine Triphosphate 0.02564 Carcinoma, Renal Cell 0.05196 Calcium Channels 0.02538 Kidney Failure, Chronic 0.03188 Calcium Signaling 0.02454 Kidney Diseases 0.02511 Ion Channel Gating 0.02411 Renal Dialysis 0.01587 Ion Channels 0.02371 Creatinine 0.01472 Sodium Channels 0.02168 Humans 0.01346 Electrophysiology 0.01627 Gene Expression Regulation, Fungal 0.01325 Potassium Channels, Voltage-Gated 0.01387 Kidney Glomerulus 0.01060 Rats 0.01217 Polycystic Kidney, Autosomal Dominant 0.01009 Potassium Channels 0.01090 Glomerular Filtration Rate 0.00860 Oocytes 0.01060 Kidney Transplantation 0.00751 Xenopus laevis 0.01017 Proteinuria 0.00656 Magnesium 0.00904 Genes, Fungal 0.00649 Potassium 0.00880 Kidney Failure, Acute 0.00649 Sodium 0.00844 Kidney Tubules 0.00632 Dose-Response Relationship, Drug 0.00750 Membrane Proteins 0.00602 TOPIC 109 0.00322 TOPIC 110 0.00318 transform 0.16123 p53 0.29055 fibroblast 0.10350 suppressor 0.03759 growth 0.07249 tumor 0.03367 tgf-beta 0.04699 protein 0.02863 tgf-beta1 0.02684 p16 0.02659 factor 0.02414 mdm2 0.02500 oncogen 0.02179 express 0.02246 cell 0.01778 apoptosi 0.02031 human 0.01424 cell 0.01932 signal 0.01393 pathwai 0.01531 smad 0.01351 arf 0.01511 express 0.01303 ink4a 0.01260 induc 0.01205 human 0.01226 factor-beta 0.01069 p73 0.01165 collagen 0.01012 wild-typ 0.01137 smad4 0.01005 alter 0.00993 prolifer 0.00971 p53-depend 0.00981 tgfbeta 0.00961 target 0.00946 cellular 0.00902 induc 0.00896 beta 0.00892 role 0.00853 Transforming Growth Factor beta 0.14090 Tumor Suppressor Protein p53 0.29073 Fibroblasts 0.13485 Genes, p53 0.07029 Cell Transformation, Neoplastic 0.06523 Nuclear Proteins 0.05438 Trans-Activators 0.03949 Proto-Oncogene Proteins 0.03985 DNA-Binding Proteins 0.03466 Tumor Suppressor Proteins 0.03661 Cells, Cultured 0.02530 Proto-Oncogene Proteins c-mdm2 0.03282 Mice 0.02119 Cyclin-Dependent Kinase Inhibitor p16 0.03148 Signal Transduction 0.01792 Genes, Tumor Suppressor 0.02934 Receptors, Transforming Growth Factor beta 0.01745 Apoptosis 0.02796 Smad3 Protein 0.01711 Cell Cycle Proteins 0.01925 NIH 3T3 Cells 0.01595 Gene Expression Regulation, Neoplastic 0.01639 Smad2 Protein 0.01211 Tumor Suppressor Protein p14ARF 0.01233 Humans 0.01201 DNA-Binding Proteins 0.01147 Smad Proteins 0.01112 Cyclin-Dependent Kinase Inhibitor p21 0.01081 Smad4 Protein 0.01041 Trans-Activation (Genetics) 0.01057 Cell Proliferation 0.00973 DNA Damage 0.00940 Cell Line, Transformed 0.00928 Humans 0.00544 Cell Line 0.00820 Genes, p16 0.00479 Genes, ras 0.00735 Cell Transformation, Neoplastic 0.00403 Fibrosis 0.00680 Cell Line, Tumor 0.00399 TOPIC 111 0.00314 TOPIC 112 0.00312 bind 0.30996 recombin 0.13473 site 0.21470 element 0.08040 affin 0.04495 insert 0.07784 specif 0.03368 genom 0.04548 interact 0.03287 integr 0.03535 bound 0.03103 sequenc 0.03459 recognit 0.02325 homolog 0.02549 protein 0.02083 site 0.02245 dissoci 0.01234 delet 0.01830 motif 0.01229 repeat 0.01689 complex 0.01125 transposon 0.01629 surfac 0.01011 mobil 0.01414 ligand 0.00923 contain 0.01269 target 0.00844 transposit 0.01245 recogn 0.00774 retrotransposon 0.01168 directli 0.00772 event 0.01064 determin 0.00695 transpos 0.01004 contain 0.00674 termin 0.00984 pocket 0.00648 parp-1 0.00966 constant 0.00628 dna 0.00944 Protein Binding 0.19140 Recombination, Genetic 0.13714 Binding Sites 0.16501 DNA Transposable Elements 0.08939 Models, Molecular 0.02790 Base Sequence 0.05312 Kinetics 0.02232 Retroelements 0.03852 Molecular Sequence Data 0.01984 Molecular Sequence Data 0.03420 Ligands 0.01709 Mutagenesis, Insertional 0.03069 Humans 0.01674 Animals 0.01520 Amino Acid Sequence 0.01346 Repetitive Sequences, Nucleic Acid 0.01520 Surface Plasmon Resonance 0.01213 Terminal Repeat Sequences 0.01436 Binding, Competitive 0.01151 Models, Genetic 0.01401 Recombinant Proteins 0.01144 Integrases 0.01352 Protein Structure, Tertiary 0.01077 Chromosome Mapping 0.01088 Animals 0.00649 Poly(ADP-ribose) Polymerases 0.01081 DNA 0.00631 Genome 0.01074 DNA-Binding Proteins 0.00624 Transposases 0.01001 Electrophoretic Mobility Shift Assay 0.00579 Long Interspersed Nucleotide Elements 0.00941 Cell Line 0.00558 Recombinant Proteins 0.00878 Base Sequence 0.00516 Virus Integration 0.00853 Protein Conformation 0.00513 Sequence Deletion 0.00829 Mutagenesis, Site-Directed 0.00509 Blotting, Southern 0.00755 TOPIC 113 0.00310 TOPIC 114 0.00309 enzym 0.14514 antibodi 0.25404 activ 0.09988 antigen 0.07941 substrat 0.08406 monoclon 0.05335 proteas 0.04299 neutral 0.03207 cleavag 0.03866 mab 0.03150 catalyt 0.03360 specif 0.02884 site 0.02196 igg 0.01991 enzymat 0.01982 sera 0.01869 degrad 0.01653 epitop 0.01644 cleav 0.01597 recogn 0.01513 cathepsin 0.01448 reactiv 0.01389 purifi 0.01376 surfac 0.01352 serin 0.01301 elisa 0.01315 proteolyt 0.01289 immunoglobulin 0.01311 catalyz 0.01267 recombin 0.01254 specif 0.01236 detect 0.01139 inhibitor 0.01063 polyclon 0.01129 reaction 0.01041 serum 0.01029 kinet 0.01011 serolog 0.00942 biochem 0.00894 direct 0.00924 Substrate Specificity 0.09363 Antibodies, Monoclonal 0.15946 Kinetics 0.07068 Enzyme-Linked Immunosorbent Assay 0.04986 Catalysis 0.04972 Antibodies 0.04465 Recombinant Proteins 0.03939 Immunoglobulin G 0.04461 Amino Acid Sequence 0.02535 Humans 0.02991 Serine Endopeptidases 0.02500 Antibody Specificity 0.02743 Molecular Sequence Data 0.02348 Autoantibodies 0.02222 Hydrolysis 0.02118 Epitopes 0.01899 Binding Sites 0.01665 Animals 0.01765 Enzyme Activation 0.01648 Antigens, Neoplasm 0.01492 Catalytic Domain 0.01630 Mice 0.01311 Hydrogen-Ion Concentration 0.01513 Immunoglobulin Variable Region 0.01304 Enzyme Stability 0.01255 Immunoglobulin M 0.01276 Models, Molecular 0.01170 Antibodies, Viral 0.01254 Peptide Hydrolases 0.01117 Antibodies, Neoplasm 0.01215 Mutagenesis, Site-Directed 0.01082 Radioimmunotherapy 0.00967 Escherichia coli 0.00962 Rabbits 0.00897 Endopeptidases 0.00817 Immunoglobulin Fragments 0.00783 Cysteine Endopeptidases 0.00792 Blotting, Western 0.00730 Animals 0.00679 Antibodies, Bacterial 0.00730 TOPIC 115 0.00307 TOPIC 116 0.00307 actin 0.05550 hospit 0.08013 cell 0.04952 patient 0.05944 regul 0.03792 medic 0.05024 filament 0.02903 unit 0.03514 protein 0.02827 percent 0.03270 cytoskeleton 0.02538 record 0.02899 rho 0.02256 care 0.02638 gtpase 0.02063 center 0.02474 migrat 0.02035 univers 0.02062 branch 0.01785 clinic 0.01913 exchang 0.01572 period 0.01676 polar 0.01560 retrospect 0.01495 cytoskelet 0.01516 admiss 0.01315 format 0.01472 methods 0.01253 myosin 0.01423 intens 0.01249 dynam 0.01319 year 0.01122 requir 0.01306 januari 0.01122 role 0.01300 conclusions 0.01008 function 0.01279 mean 0.01003 small 0.01106 discharg 0.00985 Actins 0.09613 Humans 0.10945 Cytoskeleton 0.05231 Retrospective Studies 0.08231 Animals 0.03782 Adult 0.02585 Cell Movement 0.03779 Middle Aged 0.02018 Microfilament Proteins 0.03697 United States 0.01918 rho GTP-Binding Proteins 0.02316 Adolescent 0.01721 Cytoskeletal Proteins 0.01877 Aged 0.01610 Guanine Nucleotide Exchange Factors 0.01302 Hospitalization 0.01585 cdc42 GTP-Binding Protein 0.01299 Prospective Studies 0.01121 rac GTP-Binding Proteins 0.01220 Referral and Consultation 0.01071 Mice 0.01213 Length of Stay 0.01014 Microscopy, Fluorescence 0.01063 Aged, 80 and over 0.00918 Humans 0.01053 Infant 0.00900 rhoA GTP-Binding Protein 0.01042 Hospitals, University 0.00875 rac1 GTP-Binding Protein 0.01021 Hospitals 0.00853 Cell Polarity 0.00981 Prescriptions, Drug 0.00850 Models, Biological 0.00924 Child, Preschool 0.00761 Nerve Tissue Proteins 0.00921 Child 0.00653 Microfilaments 0.00849 Emergency Service, Hospital 0.00653 GTP Phosphohydrolases 0.00799 Hospital Mortality 0.00536 TOPIC 117 0.00304 TOPIC 118 0.00299 discuss 0.03700 membran 0.19576 concept 0.03346 plasma 0.02801 theori 0.02050 intracellular 0.02568 approach 0.01909 traffick 0.02382 problem 0.01873 vesicl 0.02360 paper 0.01776 mthfr 0.02051 research 0.01765 folat 0.01949 context 0.01540 homocystein 0.01785 work 0.01370 compart 0.01608 consid 0.01360 surfac 0.01560 wai 0.01324 endoplasm 0.01523 articl 0.01283 reticulum 0.01479 view 0.01278 local 0.01454 understand 0.01235 cytosol 0.01383 practic 0.01226 outer 0.01357 aspect 0.01209 golgi 0.01304 framework 0.01191 endosom 0.01271 term 0.01180 protein 0.01105 issu 0.01170 cytoplasm 0.01099 perspect 0.01122 transloc 0.01064 Humans 0.23810 Cell Membrane 0.10188 Animals 0.03218 Protein Transport 0.06010 History, 20th Century 0.01097 Membrane Proteins 0.04647 United States 0.00985 Endoplasmic Reticulum 0.03582 Models, Biological 0.00956 Methylenetetrahydrofolate Reductase (NADPH2) 0.03021 Terminology 0.00913 Endocytosis 0.02813 Research Design 0.00808 Homocysteine 0.02787 History, 19th Century 0.00548 Animals 0.02095 Child 0.00512 Golgi Apparatus 0.01919 Psychological Theory 0.00401 Folic Acid 0.01542 Pregnancy 0.00393 Endosomes 0.01469 Models, Psychological 0.00382 Vesicular Transport Proteins 0.01388 Models, Theoretical 0.00375 Microscopy, Confocal 0.01091 Philosophy 0.00364 Membrane Glycoproteins 0.00989 Concept Formation 0.00332 Lysosomes 0.00916 Evolution 0.00318 Membrane Microdomains 0.00890 Adult 0.00314 Cytosol 0.00861 Research 0.00289 Hyperhomocysteinemia 0.00813 Neurosciences 0.00278 Intracellular Membranes 0.00776 Phenotype 0.00267 Humans 0.00773 TOPIC 119 0.00298 TOPIC 120 0.00298 select 0.26207 host 0.03934 adapt 0.07464 speci 0.03774 evolut 0.06623 insect 0.03628 fit 0.03251 parasit 0.02598 evolutionari 0.02909 larva 0.02149 natur 0.02771 adult 0.01809 evolv 0.02186 trap 0.01616 environ 0.01886 coloni 0.01599 competit 0.01691 differ 0.01426 gener 0.01377 pheromon 0.01302 plastic 0.01048 predat 0.00974 direct 0.00958 egg 0.00954 advantag 0.00931 larval 0.00952 diverg 0.00910 aphid 0.00918 strong 0.00865 feed 0.00874 pressur 0.00854 field 0.00873 trait 0.00832 natur 0.00815 neutral 0.00832 juvenil 0.00802 constraint 0.00828 suggest 0.00780 forc 0.00763 colour 0.00705 Selection (Genetics) 0.13676 Animals 0.23485 Evolution 0.10630 Larva 0.04948 Animals 0.08037 Insect Proteins 0.02382 Evolution, Molecular 0.06636 Moths 0.01962 Adaptation, Physiological 0.06268 Host-Parasite Relations 0.01830 Models, Genetic 0.03380 Insects 0.01690 Adaptation, Biological 0.01607 Species Specificity 0.01613 Variation (Genetics) 0.01585 Feeding Behavior 0.01392 Models, Biological 0.01394 Beetles 0.01266 Environment 0.01258 Wasps 0.01182 Humans 0.01151 Pest Control, Biological 0.01123 Phenotype 0.00717 Pheromones 0.01093 Analysis of Variance 0.00677 Bees 0.00998 Mutation 0.00581 Population Density 0.00976 Reproduction 0.00566 Insecticides 0.00968 Time Factors 0.00537 Bombyx 0.00902 Ecosystem 0.00467 Aphids 0.00898 Genetics, Population 0.00460 Diptera 0.00873 Species Specificity 0.00405 Ants 0.00832 Competitive Behavior 0.00364 Insect Control 0.00773 TOPIC 121 0.00297 TOPIC 122 0.00292 infect 0.07953 growth 0.10163 bacteri 0.06692 egfr 0.10145 pathogen 0.06029 factor 0.09882 host 0.04409 receptor 0.09511 bacteria 0.04288 epiderm 0.05108 virul 0.02362 kinas 0.03865 strain 0.01986 tyrosin 0.03717 pseudomona 0.01498 egf 0.03204 aureu 0.01469 inhibitor 0.02752 biofilm 0.01464 kit 0.02590 aeruginosa 0.01432 gefitinib 0.02023 staphylococcu 0.01274 c-kit 0.01762 antimicrobi 0.01203 gist 0.01702 caus 0.01011 cell 0.01433 organ 0.00988 pdgf 0.01189 microbi 0.00986 activ 0.01156 defens 0.00903 signal 0.01094 horizont 0.00902 express 0.01063 streptococcu 0.00822 platelet-deriv 0.00986 spp 0.00790 target 0.00911 Bacterial Proteins 0.07287 Receptor, Epidermal Growth Factor 0.19299 Virulence 0.04377 Epidermal Growth Factor 0.05728 Bacteria 0.04141 Quinazolines 0.05443 Anti-Bacterial Agents 0.03452 Proto-Oncogene Proteins c-kit 0.04445 Staphylococcus aureus 0.02961 Antineoplastic Agents 0.04385 DNA, Bacterial 0.02954 Protein Kinase Inhibitors 0.03005 Pseudomonas aeruginosa 0.02379 Signal Transduction 0.02434 Genes, Bacterial 0.02338 Platelet-Derived Growth Factor 0.01812 Gene Expression Regulation, Bacterial 0.01925 Gastrointestinal Stromal Tumors 0.01770 Biofilms 0.01383 Receptor, erbB-2 0.01733 Bacterial Infections 0.01331 Phosphorylation 0.01729 Colony Count, Microbial 0.01309 Humans 0.01493 Genome, Bacterial 0.01305 Receptor Protein-Tyrosine Kinases 0.01350 Virulence Factors 0.01154 Transforming Growth Factor alpha 0.01092 Humans 0.01140 Drug Resistance, Neoplasm 0.00987 Staphylococcal Infections 0.01121 Antibodies, Monoclonal 0.00848 Microbial Sensitivity Tests 0.01007 Ligands 0.00836 Symbiosis 0.00974 Receptor, Platelet-Derived Growth Factor alpha 0.00776 Bacterial Outer Membrane Proteins 0.00937 Immunohistochemistry 0.00739 Gram-Negative Bacteria 0.00933 Carcinoma, Non-Small-Cell Lung 0.00713 TOPIC 123 0.00292 TOPIC 124 0.00292 model 0.33941 human 0.76562 dynam 0.04825 mous 0.03819 network 0.04201 primat 0.02422 experiment 0.03582 monkei 0.02254 simul 0.02555 rhesu 0.01114 base 0.01600 rodent 0.01096 predict 0.01469 macaqu 0.01029 propos 0.01412 chimpanze 0.00958 paramet 0.01141 anim 0.00856 system 0.01129 murin 0.00594 stochast 0.00994 highli 0.00492 biolog 0.00937 nonhuman 0.00471 theoret 0.00930 baboon 0.00456 gener 0.00901 non-human 0.00345 mathemat 0.00861 implic 0.00328 connect 0.00842 ident 0.00312 comput 0.00776 potenti 0.00304 explain 0.00700 model 0.00302 fit 0.00675 endogen 0.00239 fluctuat 0.00668 macaca 0.00217 Models, Biological 0.14498 Humans 0.41727 Computer Simulation 0.09451 Animals 0.06001 Animals 0.05770 Mice 0.02931 Models, Genetic 0.04765 Macaca mulatta 0.02560 Models, Theoretical 0.03587 Species Specificity 0.01265 Models, Statistical 0.02671 Pan troglodytes 0.01163 Stochastic Processes 0.02551 Genome, Human 0.00739 Models, Chemical 0.01610 Primates 0.00717 Humans 0.01366 Macaca fascicularis 0.00608 Kinetics 0.01347 Cell Line 0.00525 Algorithms 0.01328 Macaca 0.00334 Signal Transduction 0.00893 Cells, Cultured 0.00323 Nonlinear Dynamics 0.00889 Recombinant Proteins 0.00315 Time Factors 0.00807 Disease Models, Animal 0.00308 Disease Models, Animal 0.00795 Base Sequence 0.00289 Mathematics 0.00732 Molecular Sequence Data 0.00206 Computational Biology 0.00705 DNA 0.00206 Neural Networks (Computer) 0.00657 DNA, Complementary 0.00199 Gene Expression Regulation 0.00492 Papio 0.00199 Models, Neurological 0.00465 Models, Animal 0.00184 TOPIC 125 0.00291 TOPIC 126 0.00290 score 0.11280 bone 0.20960 assess 0.06182 marrow 0.04586 qualiti 0.05241 osteoblast 0.02340 measur 0.05190 fractur 0.02324 scale 0.04174 miner 0.02179 life 0.03427 bmd 0.02115 valid 0.02573 hip 0.01661 disabl 0.02528 osteoporosi 0.01587 evalu 0.02056 spine 0.01560 reliabl 0.01679 densiti 0.01541 health 0.01617 osteoclast 0.01393 questionnair 0.01556 skelet 0.01309 instrument 0.01478 joint 0.01137 agreement 0.01347 alkalin 0.01123 item 0.01165 knee 0.01051 mean 0.01137 phosphatas 0.01035 qol 0.01083 hand 0.00972 statu 0.01012 femor 0.00971 outcom 0.00989 foot 0.00953 clinic 0.00986 radiograph 0.00845 Humans 0.07600 Bone Density 0.04786 Quality of Life 0.07420 Humans 0.04695 Questionnaires 0.05787 Bone and Bones 0.04294 Reproducibility of Results 0.05103 Osteoblasts 0.03590 Severity of Illness Index 0.02636 Bone Marrow Cells 0.02713 Adult 0.02580 Osteoporosis 0.02588 Middle Aged 0.02535 Bone Neoplasms 0.02119 Disability Evaluation 0.02113 Osteoclasts 0.02115 Activities of Daily Living 0.02001 Femur 0.01846 Health Status 0.01948 Osteogenesis 0.01801 Aged 0.01850 Alkaline Phosphatase 0.01657 Psychometrics 0.01730 Diphosphonates 0.01615 Health Status Indicators 0.01497 Tibia 0.01245 Disabled Persons 0.01459 Bone Resorption 0.01196 Observer Variation 0.01139 Carrier Proteins 0.00927 Mental Retardation 0.00985 Bone Marrow 0.00908 Sickness Impact Profile 0.00880 Collagen Type I 0.00866 Outcome Assessment (Health Care) 0.00835 Bone Development 0.00851 Prospective Studies 0.00816 Osteocalcin 0.00787 Aged, 80 and over 0.00737 Aged 0.00776 TOPIC 127 0.00289 TOPIC 128 0.00286 carbon 0.03323 skin 0.16468 solut 0.03195 keratinocyt 0.04969 concentr 0.02048 hair 0.03663 water 0.02030 cutan 0.03042 nitrogen 0.02021 pigment 0.02357 sourc 0.01631 epiderm 0.02270 liquid 0.01577 epidermi 0.01872 determin 0.01468 uvb 0.01756 phosphat 0.01391 psoriasi 0.01690 acet 0.01379 keratin 0.01580 chromatographi 0.01215 ultraviolet 0.01536 condit 0.01206 melanocyt 0.01378 yield 0.01191 basal 0.01374 sodium 0.01069 topic 0.01295 buffer 0.01061 dermal 0.00988 separ 0.00964 uva 0.00981 column 0.00958 bcc 0.00970 product 0.00953 exposur 0.00892 isotop 0.00942 examin 0.00854 mol 0.00932 lesion 0.00830 Humans 0.04361 Skin 0.09824 Chromatography, High Pressure Liquid 0.03895 Skin Neoplasms 0.08759 Hydrogen-Ion Concentration 0.03864 Ultraviolet Rays 0.07671 Carbon 0.01927 Keratinocytes 0.07258 Nitrogen 0.01896 Humans 0.04940 Water 0.01608 Epidermis 0.03474 Carbon Dioxide 0.01183 Psoriasis 0.02436 Culture Media 0.01066 Hair 0.01731 Adsorption 0.00997 Skin Diseases 0.01570 Kinetics 0.00906 Adult 0.01448 Animals 0.00853 Carcinoma, Basal Cell 0.01199 Reproducibility of Results 0.00849 Sunlight 0.01187 Carbon Isotopes 0.00800 Melanocytes 0.01038 Time Factors 0.00740 Melanins 0.00977 Electrochemistry 0.00698 Hair Follicle 0.00965 Oxidation-Reduction 0.00641 Middle Aged 0.00743 Chromatography, Liquid 0.00614 Administration, Topical 0.00709 Sensitivity and Specificity 0.00603 Skin Pigmentation 0.00640 Phosphates 0.00599 Dermatologic Agents 0.00628 Fermentation 0.00592 Alopecia 0.00586 TOPIC 129 0.00286 TOPIC 130 0.00283 muscl 0.21886 regul 0.25157 skelet 0.05816 regulatori 0.07149 smooth 0.04233 role 0.04960 muscular 0.03858 control 0.04770 dystrophi 0.03803 function 0.04536 fiber 0.03696 mechan 0.03480 myopathi 0.01818 cellular 0.03013 contract 0.01768 kei 0.02307 smc 0.01512 process 0.02151 myoblast 0.01372 modul 0.02003 weak 0.01207 involv 0.01701 neuromuscular 0.01110 homeostasi 0.01624 atrophi 0.01085 network 0.01526 dmd 0.01011 act 0.01493 dystrophin 0.00953 physiolog 0.01358 myogen 0.00927 neg 0.01293 duchenn 0.00755 critic 0.01279 forc 0.00754 coordin 0.01263 mdx 0.00728 balanc 0.01232 relax 0.00722 specif 0.01213 Muscle, Skeletal 0.18773 Animals 0.18677 Muscle Proteins 0.02898 Gene Expression Regulation 0.06652 Muscular Dystrophy, Duchenne 0.02614 Humans 0.05733 Muscle Fibers 0.02602 Signal Transduction 0.03064 Humans 0.02307 Models, Biological 0.02611 Muscular Diseases 0.02120 Homeostasis 0.02362 Muscles 0.02035 Transcription Factors 0.02126 Muscular Dystrophies 0.01985 Mice 0.01757 Muscle Contraction 0.01955 Transcription, Genetic 0.01493 Dystrophin 0.01824 Gene Expression Regulation, Developmental 0.01241 Myotonic Dystrophy 0.01330 DNA-Binding Proteins 0.01179 Myocytes, Smooth Muscle 0.01284 Mutation 0.00687 Muscle, Smooth 0.01226 Genes, Regulator 0.00625 Myoblasts 0.01089 Feedback, Biochemical 0.00578 Electromyography 0.01089 Repressor Proteins 0.00531 Mice, Inbred mdx 0.01012 Cell Differentiation 0.00450 Muscle, Smooth, Vascular 0.00820 Carrier Proteins 0.00357 Immunohistochemistry 0.00793 Trypanosoma brucei brucei 0.00337 Animals 0.00786 Trans-Activators 0.00310 Adult 0.00724 Molecular Sequence Data 0.00299 TOPIC 131 0.00280 TOPIC 132 0.00280 isol 0.03956 recent 0.08325 pathogen 0.03305 discuss 0.05147 fungal 0.03071 develop 0.04652 fungi 0.02624 current 0.04158 speci 0.02344 understand 0.03390 wall 0.02218 advanc 0.03301 candida 0.02026 research 0.03148 fungu 0.02014 past 0.02868 produc 0.01943 year 0.02656 albican 0.01796 decad 0.02504 yeast 0.01767 articl 0.02052 aspergillu 0.01757 focus 0.02013 strain 0.01606 summar 0.01996 spore 0.01314 focu 0.01929 product 0.01149 knowledg 0.01916 caus 0.01011 futur 0.01834 filament 0.01001 emerg 0.01612 growth 0.00964 review 0.01572 grow 0.00918 progress 0.01487 fusarium 0.00913 particular 0.01429 Fungal Proteins 0.06471 Humans 0.32991 DNA, Fungal 0.05221 Animals 0.10159 Ascomycota 0.04493 Models, Biological 0.01277 Gene Expression Regulation, Fungal 0.04262 Neoplasms 0.00901 Genes, Fungal 0.03463 Forecasting 0.00701 Plant Diseases 0.03043 United States 0.00494 Candida albicans 0.02734 Prognosis 0.00286 Antifungal Agents 0.02667 Research 0.00278 Fungi 0.02460 Mice 0.00274 Spores, Fungal 0.02127 Clinical Trials 0.00235 Cell Wall 0.01238 Genetic Predisposition to Disease 0.00227 Basidiomycota 0.01230 History, 20th Century 0.00227 Hyphae 0.01179 Drug Design 0.00223 Fusarium 0.01156 Molecular Biology 0.00219 Virulence 0.01128 Signal Transduction 0.00219 Aspergillus nidulans 0.01081 Child 0.00200 Candida 0.00987 Mutation 0.00188 Genome, Fungal 0.00979 Biomedical Research 0.00188 Culture Media 0.00964 Disease Models, Animal 0.00180 Candidiasis 0.00917 Aging 0.00176 TOPIC 133 0.00279 TOPIC 134 0.00275 ratio 0.13971 lipid 0.07787 interv 0.07074 cholesterol 0.05473 associ 0.05606 fatti 0.04531 confid 0.05563 lipoprotein 0.03773 regress 0.04663 apoe 0.03643 odd 0.04614 acid 0.03600 risk 0.04211 apolipoprotein 0.02433 adjust 0.03959 level 0.02229 studi 0.02964 plasma 0.02195 compar 0.02306 ldl 0.02151 logist 0.02066 metabol 0.02054 signific 0.01816 increas 0.01687 methods 0.01643 triglycerid 0.01541 hazard 0.01428 hdl 0.01339 analysi 0.01410 statin 0.01131 determin 0.01338 apo 0.01105 multivari 0.01329 low-dens 0.01080 conclusions 0.01138 epsilon4 0.01058 statist 0.01119 phospholipid 0.00999 cohort 0.01063 sterol 0.00988 Middle Aged 0.08212 Apolipoproteins E 0.06409 Odds Ratio 0.06906 Cholesterol 0.06114 Aged 0.06219 Lipids 0.04685 Risk Factors 0.05959 Triglycerides 0.04350 Logistic Models 0.05704 Lipid Metabolism 0.03823 Case-Control Studies 0.05098 Humans 0.03452 Adult 0.04886 Fatty Acids 0.03189 Cohort Studies 0.03632 Arteriosclerosis 0.02750 Humans 0.03310 Lipoproteins 0.02207 Regression Analysis 0.02347 Receptors, LDL 0.02019 Multivariate Analysis 0.01899 Hydroxymethylglutaryl-CoA Reductase Inhibitors 0.01812 Confidence Intervals 0.01718 Apolipoproteins B 0.01644 Prospective Studies 0.01498 Hypercholesterolemia 0.01517 Aged, 80 and over 0.01219 Lipoproteins, LDL 0.01297 Proportional Hazards Models 0.00936 Phospholipids 0.01113 Risk Assessment 0.00719 Apolipoprotein A-I 0.01034 Smoking 0.00704 Lipoproteins, HDL 0.00946 Risk 0.00684 Anticholesteremic Agents 0.00866 Sex Factors 0.00535 Lipoprotein Lipase 0.00858 Predictive Value of Tests 0.00495 Carrier Proteins 0.00850 TOPIC 135 0.00274 TOPIC 136 0.00266 brain 0.05690 prostat 0.24394 seizur 0.04233 cancer 0.19517 epilepsi 0.03797 androgen 0.03750 neurolog 0.02545 psa 0.02584 sleep 0.02368 progress 0.02193 cerebr 0.02064 npc 0.02032 lobe 0.01782 lncap 0.01951 disturb 0.01555 men 0.01307 onset 0.01461 pca 0.01299 abnorm 0.01427 pc-3 0.01247 patient 0.01387 increas 0.01235 eeg 0.01342 antigen 0.01101 disord 0.01279 benign 0.00981 matter 0.01131 nasopharyng 0.00965 ataxia 0.01114 androgen-independ 0.00890 gener 0.01107 prostate-specif 0.00839 sever 0.01056 suggest 0.00837 find 0.00992 bph 0.00824 tempor 0.00938 clusterin 0.00804 includ 0.00891 prostatectomi 0.00766 Brain 0.08182 Prostatic Neoplasms 0.33599 Humans 0.06480 Prostate-Specific Antigen 0.04650 Epilepsy 0.05302 Receptors, Androgen 0.04037 Electroencephalography 0.04974 Prostate 0.03711 Magnetic Resonance Imaging 0.04481 Humans 0.03522 Anticonvulsants 0.02719 Androgens 0.02929 Seizures 0.01990 Adenocarcinoma 0.02669 Infant 0.01626 Prostatic Hyperplasia 0.01759 Child 0.01626 Nasopharyngeal Neoplasms 0.01528 Brain Diseases 0.01161 Prostatectomy 0.01384 Adult 0.01013 Androgen Antagonists 0.01318 Adolescent 0.00949 Disease Progression 0.01244 Age of Onset 0.00801 Gene Expression Regulation, Neoplastic 0.01199 Child, Preschool 0.00689 Tumor Markers, Biological 0.01054 Cerebral Cortex 0.00665 Neoplasms 0.00931 Middle Aged 0.00657 Antineoplastic Agents, Hormonal 0.00877 Epilepsy, Temporal Lobe 0.00653 Cell Line, Tumor 0.00807 Sleep 0.00633 Aged 0.00667 Epilepsy, Generalized 0.00589 Neoplasms, Hormone-Dependent 0.00593 Diagnosis, Differential 0.00529 Prostatic Intraepithelial Neoplasia 0.00437 TOPIC 137 0.00265 TOPIC 138 0.00264 imag 0.13397 marker 0.21084 volum 0.04188 diagnosi 0.13988 magnet 0.03886 diagnost 0.09308 reson 0.03417 clinic 0.06364 mri 0.02992 molecular 0.03561 scan 0.02810 diagnos 0.02177 measur 0.02181 biomark 0.02167 tomographi 0.01960 specif 0.02058 evalu 0.01946 tool 0.01541 perform 0.01714 confirm 0.01538 comput 0.01706 establish 0.01360 digit 0.01554 valu 0.01258 techniqu 0.01509 assess 0.01244 resolut 0.01467 earli 0.01187 assess 0.01466 cea 0.01166 ultrasound 0.01390 reliabl 0.01070 area 0.01115 suspect 0.01051 pet 0.01085 detect 0.01043 contrast 0.00950 monitor 0.00997 monitor 0.00875 distinguish 0.00968 Magnetic Resonance Imaging 0.12454 Humans 0.13261 Image Processing, Computer-Assisted 0.05780 Tumor Markers, Biological 0.09172 Humans 0.05441 Biological Markers 0.09126 Tomography, X-Ray Computed 0.04933 Diagnosis, Differential 0.05764 Positron-Emission Tomography 0.02869 Sensitivity and Specificity 0.04172 Sensitivity and Specificity 0.02630 Genetic Markers 0.03192 Imaging, Three-Dimensional 0.02233 Prognosis 0.01853 Radiopharmaceuticals 0.02005 Carcinoembryonic Antigen 0.01255 Contrast Media 0.01509 Predictive Value of Tests 0.01168 Magnetic Resonance Spectroscopy 0.01360 Middle Aged 0.00881 Image Interpretation, Computer-Assisted 0.01220 Reproducibility of Results 0.00860 Reproducibility of Results 0.01120 Adult 0.00819 Adult 0.01112 Molecular Diagnostic Techniques 0.00648 Tomography, Emission-Computed, Single-Photon 0.01038 Aged 0.00640 Middle Aged 0.01025 Polymerase Chain Reaction 0.00532 Fluorodeoxyglucose F18 0.00930 Neoplasm Staging 0.00474 Image Enhancement 0.00897 Risk Assessment 0.00411 Phantoms, Imaging 0.00856 Biopsy 0.00328 Brain 0.00835 Child 0.00324 Aged 0.00744 Animals 0.00299 TOPIC 139 0.00264 TOPIC 140 0.00262 beta-catenin 0.07892 activ 0.14715 signal 0.07738 nf-kappab 0.07961 pathwai 0.06904 factor 0.04325 wnt 0.05962 nuclear 0.04111 activ 0.03110 transcript 0.03407 c-myc 0.02691 express 0.03069 role 0.02319 cell 0.02870 regul 0.01807 induc 0.02654 suggest 0.01523 inhibit 0.02258 canon 0.01452 constitut 0.01977 promot 0.01400 ap-1 0.01912 target 0.01378 regul 0.01711 report 0.01326 c-jun 0.01290 involv 0.01239 suppress 0.01137 protein 0.01204 p65 0.01126 glycogen 0.01180 kappa 0.01092 develop 0.01156 curcumin 0.01079 myc 0.01065 transloc 0.01066 mechan 0.01035 nfkappab 0.01058 tcf 0.01016 c-fo 0.01042 Cytoskeletal Proteins 0.10543 NF-kappa B 0.20846 beta Catenin 0.10331 Transcription Factor AP-1 0.03947 Trans-Activators 0.09363 I-kappa B Proteins 0.02623 Wnt Proteins 0.08756 Humans 0.02230 Signal Transduction 0.07704 I-kappa B Kinase 0.01846 Intercellular Signaling Peptides and Proteins 0.07434 Transcription Factor RelA 0.01809 Proto-Oncogene Proteins c-myc 0.02507 Cell Nucleus 0.01729 Glycogen Synthase Kinase 3 0.02183 Proto-Oncogene Proteins c-fos 0.01667 Proteins 0.00998 Proto-Oncogene Proteins c-jun 0.01629 Transcription Factors 0.00935 Signal Transduction 0.01533 Proto-Oncogene Proteins 0.00935 Cells, Cultured 0.01424 Lymphoid Enhancer-Binding Factor 1 0.00861 Transcription, Genetic 0.01341 Genes, myc 0.00790 Protein-Serine-Threonine Kinases 0.01132 Phosphoproteins 0.00611 Gene Expression Regulation 0.01098 Glycoproteins 0.00574 Cell Line 0.00977 Frizzled Receptors 0.00540 Cell Line, Tumor 0.00973 Wnt1 Protein 0.00507 Curcumin 0.00894 TCF Transcription Factors 0.00491 Electrophoretic Mobility Shift Assay 0.00789 LDL-Receptor Related Proteins 0.00449 Blotting, Western 0.00781 DNA-Binding Proteins 0.00412 Transcription Factors 0.00760 TOPIC 141 0.00261 TOPIC 142 0.00259 diseas 0.55119 compound 0.12115 progress 0.07853 microm 0.05920 inflammatori 0.02731 deriv 0.05033 chronic 0.02327 chemic 0.03112 patient 0.02056 analogu 0.02048 pathogenesi 0.01837 potent 0.01864 clinic 0.01723 activ 0.01825 crohn 0.01373 analog 0.01727 coliti 0.01358 agent 0.01636 common 0.01264 novel 0.01587 associ 0.01161 select 0.01478 ibd 0.01058 ring 0.01461 onset 0.00836 cytotox 0.01412 cours 0.00795 exhibit 0.01337 card15 0.00771 natur 0.01315 bowel 0.00762 potenc 0.01297 inflamm 0.00753 synthes 0.01291 ulcer 0.00724 structur 0.01286 etiolog 0.00703 biolog 0.01264 involv 0.00699 new 0.01234 Humans 0.20485 Molecular Structure 0.07334 Disease Progression 0.05973 Structure-Activity Relationship 0.06512 Crohn Disease 0.04442 Antineoplastic Agents 0.02970 Genetic Predisposition to Disease 0.02714 Animals 0.02949 Colitis, Ulcerative 0.02307 Stereoisomerism 0.02500 Intracellular Signaling Peptides and Proteins 0.02038 Drug Screening Assays, Antitumor 0.02203 Inflammatory Bowel Diseases 0.01866 Models, Molecular 0.01597 Adult 0.01569 Magnetic Resonance Spectroscopy 0.01568 Chronic Disease 0.01393 Inhibitory Concentration 50 0.01487 Aged 0.01288 Dose-Response Relationship, Drug 0.01449 Middle Aged 0.01195 Plant Extracts 0.01445 Inflammation 0.01183 Drug Design 0.01229 Severity of Illness Index 0.00872 Plants, Medicinal 0.01131 Child 0.00755 Molecular Conformation 0.01114 Mutation 0.00734 Humans 0.01085 Diagnosis, Differential 0.00654 Flavonoids 0.00957 Risk Factors 0.00621 Quantitative Structure-Activity Relationship 0.00771 Celiac Disease 0.00591 Indoles 0.00699 Prognosis 0.00533 Phenols 0.00661 Behcet Syndrome 0.00428 Models, Chemical 0.00635 TOPIC 143 0.00259 TOPIC 144 0.00258 receptor 0.41018 adhes 0.11733 ligand 0.06759 alcohol 0.06695 antagonist 0.03886 integrin 0.05576 agonist 0.03282 cell 0.04645 mediat 0.01509 molecul 0.04528 function 0.01311 e-cadherin 0.04141 gaba 0.01122 focal 0.01928 subunit 0.01004 ethanol 0.01860 action 0.00900 depend 0.01839 pharmacolog 0.00849 cell-cel 0.01736 bind 0.00786 adher 0.01406 role 0.00771 interact 0.01365 coupl 0.00717 spread 0.01310 opioid 0.00692 fak 0.01267 modul 0.00652 cadherin 0.01234 select 0.00641 associ 0.01130 protein-coupl 0.00626 surfac 0.01103 gpcr 0.00623 migrat 0.01091 nmda 0.00589 role 0.01069 receptor-medi 0.00574 beta1 0.01058 Ligands 0.09566 Cell Adhesion 0.15237 Animals 0.06772 Cadherins 0.09453 Receptors, G-Protein-Coupled 0.04143 Cell Adhesion Molecules 0.03673 Humans 0.03324 Integrins 0.03151 Rats 0.03015 Alcoholism 0.02947 Dose-Response Relationship, Drug 0.02468 Cell Movement 0.02883 Receptors, Cell Surface 0.02459 Ethanol 0.02518 Cell Line 0.01399 Alcohol Drinking 0.02314 Receptors, N-Methyl-D-Aspartate 0.01026 Fibronectins 0.01864 Signal Transduction 0.00996 Intercellular Adhesion Molecule-1 0.01720 Cricetinae 0.00941 Cytoskeletal Proteins 0.01631 Receptors, Nicotinic 0.00937 Laminin 0.01401 Receptors, GABA-A 0.00937 Focal Adhesion Protein-Tyrosine Kinases 0.01384 Cyclic AMP 0.00882 Focal Adhesion Kinase 1 0.01159 CHO Cells 0.00823 Humans 0.01134 Cell Membrane 0.00818 Antigens, CD29 0.00866 Transfection 0.00717 Antigens, CD 0.00849 Mice 0.00695 Phosphoproteins 0.00650 Radioligand Assay 0.00560 Cell Communication 0.00650 Calcium 0.00500 Integrin alphaVbeta3 0.00607 TOPIC 145 0.00257 TOPIC 146 0.00256 interact 0.37566 invas 0.13524 protein 0.08317 cell 0.09047 function 0.03258 tumor 0.08959 yeast 0.02818 metastasi 0.08452 complex 0.02642 metastat 0.07971 identifi 0.02060 metastas 0.05476 partner 0.02005 primari 0.03789 involv 0.01970 progress 0.02459 bind 0.01632 potenti 0.01868 vitro 0.01520 dissemin 0.01779 protein-protein 0.01510 upa 0.01678 physic 0.01462 plasminogen 0.01669 suggest 0.01386 cd44 0.01505 cooper 0.01366 pai-1 0.01431 two-hybrid 0.01284 cancer 0.01417 assai 0.01248 upar 0.01397 vivo 0.01207 carcinoma 0.01363 experi 0.01106 distant 0.01326 directli 0.01086 malign 0.01202 demonstr 0.00973 osteosarcoma 0.01171 Protein Binding 0.11763 Neoplasm Metastasis 0.15198 Two-Hybrid System Techniques 0.08256 Neoplasm Invasiveness 0.14937 Immunoprecipitation 0.04053 Cell Movement 0.04830 Protein Interaction Mapping 0.03427 Urinary Plasminogen Activator 0.02719 Saccharomyces cerevisiae 0.03231 Cell Line, Tumor 0.02312 Humans 0.03116 Humans 0.02137 Saccharomyces cerevisiae Proteins 0.02042 Antigens, CD44 0.02081 Carrier Proteins 0.01897 Disease Progression 0.02043 Animals 0.01560 Bone Neoplasms 0.02043 Cell Line 0.01492 Lung Neoplasms 0.01730 Protein Structure, Tertiary 0.01364 Gene Expression Regulation, Neoplastic 0.01597 Glutathione Transferase 0.01291 Plasminogen Activator Inhibitor 1 0.01589 Hela Cells 0.01100 Osteosarcoma 0.01396 Nuclear Proteins 0.00989 Receptors, Cell Surface 0.01280 Transcription Factors 0.00921 Tumor Cells, Cultured 0.00822 Adaptor Proteins, Signal Transducing 0.00618 Adenocarcinoma 0.00749 Amino Acid Sequence 0.00614 Tumor Markers, Biological 0.00719 Plasmids 0.00584 Drug Combinations 0.00565 Binding Sites 0.00550 Cell Adhesion 0.00557 Mice 0.00550 Lymphatic Metastasis 0.00527 TOPIC 147 0.00253 TOPIC 148 0.00251 gene 0.96566 genet 0.52880 candid 0.01234 suscept 0.02611 identifi 0.00529 studi 0.02193 gene-specif 0.00186 molecular 0.02136 housekeep 0.00184 develop 0.02129 -region 0.00067 basi 0.01672 known 0.00043 complex 0.01621 co-regul 0.00043 environment 0.01606 multigen 0.00036 individu 0.01490 polya 0.00023 contribut 0.01179 ats 0.00023 identifi 0.01072 multi-gen 0.00023 counsel 0.00987 preferenti 0.00019 common 0.00970 belong 0.00018 c-myc 0.00965 analys 0.00017 predisposit 0.00943 gc-content 0.00016 factor 0.00942 repertoir 0.00014 understand 0.00927 well-studi 0.00014 implic 0.00927 nifh 0.00014 approach 0.00880 analyz 0.00013 relev 0.00859 Humans 0.05588 Genetic Predisposition to Disease 0.13904 Gene Expression Regulation 0.04748 Humans 0.06727 Animals 0.04423 Genetic Screening 0.06216 Gene Expression Profiling 0.03894 Mutation 0.02758 Reverse Transcriptase Polymerase Chain Reaction 0.03556 Polymorphism, Genetic 0.02644 Gene Expression 0.03439 Genetic Counseling 0.02168 Base Sequence 0.02894 Phenotype 0.02111 DNA Primers 0.02603 Genotype 0.01888 Multigene Family 0.01971 Variation (Genetics) 0.01831 Molecular Sequence Data 0.01416 Animals 0.01220 Transcription Factors 0.01230 Molecular Biology 0.01171 Models, Genetic 0.01022 Genetic Diseases, Inborn 0.01075 Polymerase Chain Reaction 0.00979 Pharmacogenetics 0.01018 Oligonucleotide Array Sequence Analysis 0.00927 Genetics, Medical 0.00918 Genes 0.00901 Genetic Markers 0.00865 Mice 0.00858 Linkage (Genetics) 0.00817 DNA-Binding Proteins 0.00754 Risk Factors 0.00616 Gene Therapy 0.00754 Chromosome Mapping 0.00612 Mutation 0.00671 Models, Genetic 0.00551 Sequence Analysis, DNA 0.00654 Genetic Techniques 0.00494 TOPIC 149 0.00244 TOPIC 150 0.00244 mitochondri 0.18735 target 0.30473 mtdna 0.05564 therapeut 0.08754 mitochondria 0.04597 potenti 0.05567 trna 0.03987 novel 0.04708 dna 0.02566 develop 0.04659 suggest 0.02070 strategi 0.04502 cytochrom 0.02028 approach 0.02972 ribosom 0.01996 specif 0.02737 oxidas 0.01583 select 0.02542 rrna 0.01469 design 0.02501 nuclear 0.01297 molecul 0.02280 subunit 0.01171 new 0.02081 respiratori 0.01004 therapi 0.01841 deplet 0.00957 molecular 0.01446 reveal 0.00939 drug 0.01442 indic 0.00871 repres 0.01416 plastid 0.00858 agent 0.01295 involv 0.00842 attract 0.01124 accumul 0.00810 promis 0.01057 atp 0.00796 provid 0.00866 DNA, Mitochondrial 0.18408 Humans 0.13919 Mitochondria 0.15766 Animals 0.11565 Mitochondrial Proteins 0.04186 Neoplasms 0.04613 RNA, Transfer 0.02526 Antineoplastic Agents 0.03474 Electron Transport Complex IV 0.01943 Drug Design 0.03042 Mitochondrial Diseases 0.01615 Drug Delivery Systems 0.02912 RNA, Ribosomal 0.01126 Gene Targeting 0.02025 Electron Transport 0.00821 Mice 0.01526 Ribosomal Proteins 0.00785 Gene Therapy 0.01337 Adenosine Triphosphate 0.00727 Models, Biological 0.00792 Oxygen Consumption 0.00655 Apoptosis 0.00423 Intracellular Membranes 0.00574 Cell Line, Tumor 0.00396 Electron Transport Complex I 0.00565 Cell Proliferation 0.00378 Ribosomes 0.00552 Signal Transduction 0.00315 Saccharomyces cerevisiae 0.00520 Enzyme Inhibitors 0.00302 Nucleic Acid Conformation 0.00511 Disease Models, Animal 0.00297 Base Sequence 0.00502 Time Factors 0.00279 Mitochondrial Myopathies 0.00489 Mutation 0.00275 Mitochondria, Liver 0.00485 Antibodies, Monoclonal 0.00248 Chloroplasts 0.00471 Gene Expression Regulation, Neoplastic 0.00230 TOPIC 151 0.00242 TOPIC 152 0.00242 deliveri 0.03924 alpha 0.11950 effici 0.03749 beta 0.10047 particl 0.02940 cytokin 0.05742 liposom 0.02322 necrosi 0.05503 polym 0.01991 inflammatori 0.05239 formul 0.01666 factor 0.05130 prepar 0.01492 tnf-alpha 0.04483 properti 0.01428 il-6 0.04349 cation 0.01402 inflamm 0.03644 nanoparticl 0.01311 tnf 0.03047 scaffold 0.01264 neutrophil 0.02190 poli 0.01251 il-8 0.02186 mix 0.01125 il-1beta 0.01863 releas 0.01121 tumor 0.01682 complex 0.01048 increas 0.01554 carrier 0.01017 tnfalpha 0.01347 surfac 0.00999 interleukin 0.01322 improv 0.00966 factor-alpha 0.01313 solut 0.00958 product 0.01129 deliv 0.00899 proinflammatori 0.01129 Liposomes 0.05013 Tumor Necrosis Factor-alpha 0.19645 Polymers 0.03140 Interleukin-6 0.08424 DNA 0.02764 Inflammation 0.07630 Animals 0.02728 Cytokines 0.06420 Particle Size 0.02534 Interleukin-1 0.05989 Gene Transfer Techniques 0.02226 Interleukin-8 0.03078 Nanostructures 0.02050 Neutrophils 0.02013 Drug Delivery Systems 0.02004 Receptors, Tumor Necrosis Factor 0.01188 Drug Carriers 0.01869 Humans 0.01129 Polyethylene Glycols 0.01742 Receptors, Tumor Necrosis Factor, Type I 0.00884 Cations 0.01638 Inflammation Mediators 0.00825 Biocompatible Materials 0.01421 Animals 0.00571 Polyethyleneimine 0.01326 Sialoglycoproteins 0.00467 Hydrogen-Ion Concentration 0.01226 Enzyme-Linked Immunosorbent Assay 0.00449 Microspheres 0.01032 Recombinant Proteins 0.00390 Gene Therapy 0.00959 Receptors, Tumor Necrosis Factor, Type II 0.00381 Nanotechnology 0.00896 Signal Transduction 0.00363 Humans 0.00742 Receptors, Interleukin-1 0.00363 Time Factors 0.00733 Mice 0.00326 Solubility 0.00710 Cells, Cultured 0.00290 TOPIC 153 0.00241 TOPIC 154 0.00240 gene 0.68701 bodi 0.11891 encod 0.11540 weight 0.09099 involv 0.04971 diet 0.04995 identifi 0.02129 vitamin 0.04213 put 0.01847 intak 0.03974 known 0.01701 dietari 0.03452 code 0.01014 food 0.03416 tp53 0.00749 supplement 0.03389 reveal 0.00686 nutrit 0.02451 symbol 0.00675 fat 0.02229 locu 0.00554 consumpt 0.02179 name 0.00453 feed 0.02007 homologu 0.00412 mass 0.01846 locat 0.00371 oil 0.01817 candid 0.00344 fed 0.01793 transcrib 0.00324 energi 0.01421 harbor 0.00245 gain 0.01139 impli 0.00211 effect 0.01086 fide 0.00205 composit 0.01083 bona 0.00204 meat 0.01053 Humans 0.06636 Diet 0.08411 Base Sequence 0.06346 Body Weight 0.06405 Molecular Sequence Data 0.05724 Dietary Supplements 0.03282 Multigene Family 0.02292 Humans 0.02558 Amino Acid Sequence 0.02029 Body Composition 0.01796 DNA Primers 0.01802 Body Mass Index 0.01632 Mutation, Missense 0.01630 Folic Acid 0.01623 Animals 0.01616 Energy Intake 0.01359 Gene Deletion 0.01484 Energy Metabolism 0.01281 Amino Acid Substitution 0.01398 Dietary Fats 0.01245 Gene Expression Profiling 0.01276 Animals 0.01226 Gene Expression 0.01248 Animal Feed 0.01208 Reverse Transcriptase Polymerase Chain Reaction 0.01103 Meat 0.01204 Codon, Nonsense 0.01103 Weight Gain 0.01017 Mutation 0.01071 Eating 0.00962 Transcription Factors 0.01044 Nutritional Status 0.00935 Sequence Analysis, DNA 0.00985 Fruit 0.00862 Codon 0.00840 Food Habits 0.00702 Proteins 0.00695 Vitamin E 0.00675 Gene Expression Regulation 0.00649 Dietary Proteins 0.00675 TOPIC 155 0.00238 TOPIC 156 0.00236 instabl 0.05561 differenti 0.40653 crc 0.05131 express 0.10154 microsatellit 0.04484 matur 0.05173 cancer 0.04107 cell 0.04078 colorect 0.04078 precursor 0.01710 mismatch 0.02708 termin 0.01706 loss 0.02658 develop 0.01555 msi 0.02296 marker 0.01412 hereditari 0.02261 demonstr 0.01376 repair 0.02103 induc 0.01293 case 0.02089 immatur 0.01188 sporad 0.02074 role 0.01089 mmr 0.01716 factor 0.01079 frequenc 0.01538 bmp 0.01063 mutat 0.01482 regul 0.00906 alter 0.01453 runx2 0.00857 hnpcc 0.01438 suggest 0.00830 hmlh1 0.01431 poorli 0.00760 loh 0.01299 dedifferenti 0.00647 mlh1 0.01282 contrast 0.00647 Microsatellite Repeats 0.10085 Cell Differentiation 0.36174 Colorectal Neoplasms 0.07068 Mice 0.02656 Colorectal Neoplasms, Hereditary Nonpolyposis 0.04584 Bone Morphogenetic Proteins 0.02289 Base Pair Mismatch 0.04478 Transcription Factors 0.02024 Neoplasm Proteins 0.04437 Adipocytes 0.01105 Carrier Proteins 0.04105 DNA-Binding Proteins 0.01096 MutS Homolog 2 Protein 0.04064 Animals 0.00929 Nuclear Proteins 0.04041 Core Binding Factor Alpha 1 Subunit 0.00873 DNA-Binding Proteins 0.03760 Gene Expression Regulation, Developmental 0.00840 Proto-Oncogene Proteins 0.03492 Cells, Cultured 0.00757 Loss of Heterozygosity 0.03276 Reverse Transcriptase Polymerase Chain Reaction 0.00748 DNA Repair 0.03027 Cell Lineage 0.00645 Genomic Instability 0.02861 Tretinoin 0.00585 Humans 0.01276 Neoplasm Proteins 0.00539 DNA, Neoplasm 0.01258 Gene Expression Regulation 0.00515 Germ-Line Mutation 0.01226 Cell Line 0.00511 Chromosomal Instability 0.01078 Up-Regulation 0.00413 Middle Aged 0.00802 Humans 0.00371 Immunohistochemistry 0.00779 Transforming Growth Factor beta 0.00344 Aged 0.00728 Cell Proliferation 0.00334 TOPIC 157 0.00234 TOPIC 158 0.00234 factor 0.13718 women 0.16459 platelet 0.05492 men 0.07382 bleed 0.02767 design 0.06736 venou 0.02659 studi 0.05346 thrombosi 0.02426 objective 0.04123 coagul 0.01912 main 0.03918 thrombin 0.01418 conclusions 0.03590 leiden 0.01315 year 0.02662 defici 0.01288 particip 0.02418 fibrinogen 0.01245 methods 0.02094 prothrombin 0.01120 setting 0.01844 viii 0.01092 outcome 0.01612 plasma 0.01089 prospect 0.01448 thromboembol 0.01072 mean 0.01403 caus 0.01027 study 0.01207 associ 0.01011 examin 0.01204 von 0.00976 determin 0.01096 anticoagul 0.00954 measures 0.01082 hemophilia 0.00947 measur 0.01079 vii 0.00942 histori 0.01038 Humans 0.04324 Adult 0.12585 Factor V 0.03698 Middle Aged 0.11598 Venous Thrombosis 0.03655 Aged 0.05741 Blood Platelets 0.03384 Prospective Studies 0.04777 Hemophilia A 0.03277 Humans 0.04272 Prothrombin 0.02506 Cross-Sectional Studies 0.03846 Thrombophilia 0.02477 Sex Factors 0.02990 Thrombosis 0.02459 Cohort Studies 0.01857 Anticoagulants 0.02323 Age Factors 0.01324 Factor VIII 0.02248 Adolescent 0.01132 Blood Coagulation 0.01888 Postmenopause 0.01067 Thrombin 0.01566 Aged, 80 and over 0.01034 von Willebrand Factor 0.01332 Aging 0.00716 Fibrinogen 0.01281 Risk Factors 0.00613 Thromboembolism 0.01281 Case-Control Studies 0.00580 Hemorrhage 0.01248 Retrospective Studies 0.00505 Recombinant Proteins 0.01173 Menopause 0.00440 Factor VII 0.01136 Women's Health 0.00393 Platelet Aggregation 0.00986 Sex Distribution 0.00384 Blood Coagulation Disorders 0.00921 Netherlands 0.00304 TOPIC 159 0.00233 TOPIC 160 0.00233 popul 0.06125 acid 0.36421 white 0.05867 amino 0.14639 ethnic 0.05702 sequenc 0.03981 american 0.04795 open 0.03756 differ 0.04678 read 0.03718 african 0.03959 frame 0.03548 group 0.03829 orf 0.02462 black 0.03559 encod 0.02411 caucasian 0.02836 protein 0.01901 asian 0.02597 nucleotid 0.01850 race 0.02517 codon 0.01720 indian 0.01665 contain 0.01706 dispar 0.01407 nucleic 0.01592 racial 0.01294 ident 0.01287 african-american 0.01283 character 0.01162 like 0.01267 similar 0.00956 higher 0.01036 substitut 0.00910 compar 0.01031 predict 0.00874 european 0.01029 put 0.00738 statu 0.01026 code 0.00705 European Continental Ancestry Group 0.10444 Amino Acid Sequence 0.13762 African Continental Ancestry Group 0.05804 Molecular Sequence Data 0.08148 African Americans 0.05753 Open Reading Frames 0.08035 Ethnic Groups 0.04889 Amino Acids 0.04785 United States 0.03522 Base Sequence 0.02821 Humans 0.03278 Sequence Homology, Amino Acid 0.02746 Asian Continental Ancestry Group 0.03038 Sequence Alignment 0.02501 Continental Population Groups 0.02174 Codon 0.01842 Jews 0.02165 Humans 0.00725 Hispanic Americans 0.01630 Animals 0.00702 Israel 0.01461 Cloning, Molecular 0.00560 Arabs 0.01338 Amino Acid Substitution 0.00509 India 0.01273 Sequence Analysis, DNA 0.00438 Socioeconomic Factors 0.01155 DNA Primers 0.00396 Adult 0.01151 Hydrogen-Ion Concentration 0.00391 Middle Aged 0.00967 Models, Molecular 0.00301 Prevalence 0.00939 DNA, Complementary 0.00301 Indians, North American 0.00930 Phylogeny 0.00283 Mexico 0.00695 Molecular Weight 0.00283 Adolescent 0.00582 Protein Structure, Tertiary 0.00250 TOPIC 161 0.00231 TOPIC 162 0.00231 residu 0.11612 chronic 0.17103 substitut 0.07392 persist 0.06730 posit 0.04459 patient 0.04637 codon 0.03785 imatinib 0.04290 acid 0.03220 abl 0.03891 mutat 0.03144 cml 0.02855 replac 0.02763 leukemia 0.02824 amino 0.02568 bcr 0.02274 conserv 0.02174 cam 0.02113 loop 0.02153 diseas 0.02002 arginin 0.01899 bcr-abl 0.01868 singl 0.01867 myeloid 0.01654 arg 0.01367 treatment 0.01480 pro 0.01337 mesyl 0.01306 cystein 0.01331 idiopath 0.01158 result 0.01229 complet 0.01117 alanin 0.01227 disord 0.01090 site 0.01202 clonal 0.00943 mutagenesi 0.01194 respons 0.00918 nucleotid 0.01186 major 0.00887 Amino Acid Substitution 0.10002 Pyrimidines 0.08833 Mutagenesis, Site-Directed 0.06550 Piperazines 0.08757 Amino Acid Sequence 0.04603 Chronic Disease 0.07485 Molecular Sequence Data 0.04561 Leukemia, Myeloid, Chronic 0.06740 Arginine 0.03292 Fusion Proteins, bcr-abl 0.04851 Codon 0.03239 Humans 0.03123 Alanine 0.02790 Antineoplastic Agents 0.02810 Mutation 0.02387 Leukemia, Myeloid, Philadelphia-Positive 0.01732 Models, Molecular 0.01321 Myeloproliferative Disorders 0.01690 Point Mutation 0.01246 Myelofibrosis 0.01514 Glycine 0.01241 Middle Aged 0.01481 Lysine 0.00966 Polycythemia Vera 0.01210 Cysteine 0.00961 Protein Kinase Inhibitors 0.01187 Proline 0.00871 Philadelphia Chromosome 0.01039 Kinetics 0.00796 Drug Resistance, Neoplasm 0.01030 Humans 0.00791 Aged 0.00911 Base Sequence 0.00772 Genes, abl 0.00883 Conserved Sequence 0.00748 Thrombocythemia, Hemorrhagic 0.00797 Amino Acids 0.00734 Interferon-alpha 0.00598 Sequence Alignment 0.00706 Adult 0.00593 TOPIC 163 0.00230 TOPIC 164 0.00230 sperm 0.08920 cell 0.42759 germ 0.05697 epitheli 0.16843 wound 0.03805 epithelium 0.04283 fertil 0.03708 basal 0.02812 testi 0.03182 normal 0.02800 spermatozoa 0.02989 polar 0.01857 testicular 0.02765 apic 0.01428 heal 0.02723 stromal 0.01186 male 0.02400 cellular 0.01172 motil 0.02356 epithelia 0.01167 semen 0.02147 differenti 0.01134 infertil 0.02011 surfac 0.01099 spermatogenesi 0.01476 prolifer 0.01076 pon1 0.01334 stroma 0.00832 cryopreserv 0.00993 layer 0.00745 sea 0.00925 lumin 0.00649 spermatid 0.00915 neoplast 0.00620 studi 0.00852 morphogenesi 0.00607 freez 0.00789 membran 0.00502 sertoli 0.00752 basolater 0.00475 Spermatozoa 0.12843 Epithelial Cells 0.22393 Testis 0.08991 Epithelium 0.04531 Spermatogenesis 0.04973 Humans 0.03552 Infertility, Male 0.04629 Immunohistochemistry 0.02621 Sperm Motility 0.03637 Animals 0.02063 Testicular Neoplasms 0.02959 Stromal Cells 0.01891 Wound Healing 0.02653 Cell Line 0.01881 Cryopreservation 0.02310 Cell Polarity 0.01471 Semen Preservation 0.02267 Cystinuria 0.01270 Sperm Count 0.02205 Amino Acid Transport Systems, Basic 0.01222 Semen 0.02124 Dogs 0.01046 Animals 0.02062 Cells, Cultured 0.00955 Oligospermia 0.02000 Cell Differentiation 0.00922 Fertility 0.01642 Cell Proliferation 0.00922 Germ Cells 0.01613 Membrane Proteins 0.00883 Sperm Injections, Intracytoplasmic 0.00935 Amino Acid Transport Systems, Neutral 0.00673 Fertilization 0.00821 Cell Transformation, Neoplastic 0.00611 Humans 0.00744 Mice 0.00544 Aryldialkylphosphatase 0.00716 Mutation, Missense 0.00535 Spermatids 0.00702 Codon, Nonsense 0.00501 TOPIC 165 0.00228 TOPIC 166 0.00226 gastric 0.16540 diseas 0.16999 tract 0.04402 arthriti 0.04720 pylori 0.03788 aggreg 0.04643 gastrointestin 0.03406 accumul 0.04545 esophag 0.03319 rheumatoid 0.02670 adenocarcinoma 0.02702 disord 0.02623 mucosa 0.02579 joint 0.02413 ulcer 0.02312 caus 0.02262 stomach 0.02116 storag 0.02236 helicobact 0.01672 inclus 0.02165 studi 0.01645 lysosom 0.02055 aim 0.01511 patholog 0.01710 upper 0.01489 huntington 0.01445 respect 0.01272 sever 0.01421 esophagu 0.01266 progress 0.01409 intestin 0.01260 lead 0.01409 methods 0.01222 neurodegen 0.01371 mucos 0.01112 synovi 0.01267 reflux 0.01062 expand 0.01175 barrett 0.01043 pathogenesi 0.01168 Stomach Neoplasms 0.19143 Arthritis, Rheumatoid 0.08559 Helicobacter pylori 0.06048 Humans 0.08389 Adenocarcinoma 0.04987 Huntington Disease 0.03755 Helicobacter Infections 0.04531 Synovial Membrane 0.01938 Gastric Mucosa 0.04392 Fabry Disease 0.01919 Esophageal Neoplasms 0.04229 Peptides 0.01690 Stomach 0.01872 Nerve Tissue Proteins 0.01676 Humans 0.01795 Gaucher Disease 0.01661 Barrett Esophagus 0.01555 Lysosomes 0.01394 Gastroesophageal Reflux 0.01430 Hepatolenticular Degeneration 0.01375 Mucins 0.01282 Neurodegenerative Diseases 0.01258 Metaplasia 0.01162 Nuclear Proteins 0.01127 Esophagus 0.01042 Severity of Illness Index 0.01064 Middle Aged 0.00979 Brain 0.00908 Aged 0.00979 alpha-Galactosidase 0.00860 Anti-Ulcer Agents 0.00893 Joints 0.00850 Gastritis 0.00883 Arthritis, Experimental 0.00801 Precancerous Conditions 0.00754 Glucosylceramidase 0.00782 Gastrointestinal Neoplasms 0.00744 Disease Progression 0.00733 Antigens, Bacterial 0.00686 Inclusion Bodies 0.00685 TOPIC 167 0.00223 TOPIC 168 0.00222 cultur 0.27595 receptor 0.13412 cell 0.15308 estrogen 0.06140 medium 0.06074 hormon 0.05498 vitro 0.05717 steroid 0.03791 condit 0.02848 nuclear 0.02128 media 0.02198 retino 0.02063 incub 0.02156 glucocorticoid 0.02006 passag 0.01276 retinoid 0.01964 grown 0.01134 progesteron 0.01780 viabil 0.01005 regul 0.01500 supernat 0.00988 eralpha 0.01401 produc 0.00982 respons 0.01399 isol 0.00961 action 0.01365 presenc 0.00936 coactiv 0.01305 monolay 0.00924 testosteron 0.01297 increas 0.00913 effect 0.01258 contain 0.00883 estradiol 0.01180 product 0.00875 vitamin 0.01092 maintain 0.00845 alpha 0.01079 primari 0.00837 dexamethason 0.01068 Cells, Cultured 0.24071 Estradiol 0.06304 Cell Culture Techniques 0.07625 Estrogen Receptor alpha 0.05350 Culture Media 0.05605 Estrogens 0.05048 Coculture Techniques 0.02379 Tretinoin 0.03767 Fibroblasts 0.01813 Receptors, Cytoplasmic and Nuclear 0.03500 Cell Survival 0.01773 Receptors, Estrogen 0.03169 Culture Media, Serum-Free 0.01310 Receptors, Retinoic Acid 0.02709 Culture Media, Conditioned 0.01202 Glucocorticoids 0.02601 Animals 0.01020 Receptors, Steroid 0.02077 Time Factors 0.00887 Dexamethasone 0.02052 Cell Line 0.00827 Estrogen Receptor beta 0.01864 Cattle 0.00823 Receptors, Progesterone 0.01844 Humans 0.00522 Receptors, Glucocorticoid 0.01726 Organ Culture Techniques 0.00502 Receptors, Androgen 0.01434 Cell Count 0.00448 Progesterone 0.01211 Spheroids, Cellular 0.00364 Receptors, Calcitriol 0.01182 Dose-Response Relationship, Drug 0.00350 Aromatase 0.01053 Tissue Culture Techniques 0.00340 Testosterone 0.01048 Bioreactors 0.00305 Retinoids 0.00865 Immunohistochemistry 0.00296 Trans-Activation (Genetics) 0.00796 TOPIC 169 0.00221 TOPIC 170 0.00220 matrix 0.10055 mass 0.08825 migrat 0.06116 gel 0.05798 extracellular 0.05387 analysi 0.04826 collagen 0.03352 electrophoresi 0.04567 cell 0.03203 spectrometri 0.03649 chemokin 0.03142 proteom 0.03120 express 0.03045 separ 0.02822 mmp 0.02519 spot 0.02615 metalloproteinas 0.02475 identifi 0.02400 tissu 0.02467 chromatographi 0.02266 mmp-2 0.02034 liquid 0.01998 mmp-9 0.01988 band 0.01755 role 0.01905 capillari 0.01736 cxcr4 0.01644 analyz 0.01559 ecm 0.01508 identif 0.01493 timp-1 0.01181 two-dimension 0.01246 stromal 0.01096 molecular 0.01245 inhibitor 0.01025 profil 0.01117 human 0.00950 detect 0.01092 mcp-1 0.00911 determin 0.01072 Cell Movement 0.09174 Proteomics 0.07131 Extracellular Matrix 0.05428 Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization 0.06598 Collagen 0.03860 Chromatography, High Pressure Liquid 0.05951 Chemokines, CXC 0.03751 Electrophoresis, Gel, Two-Dimensional 0.05906 Metalloendopeptidases 0.03691 Spectrometry, Mass, Electrospray Ionization 0.04088 Matrix Metalloproteinases 0.03012 Proteome 0.03979 Receptors, Chemokine 0.02734 Electrophoresis, Polyacrylamide Gel 0.03695 Extracellular Matrix Proteins 0.02342 Electrophoresis, Capillary 0.03127 Receptors, CXCR4 0.02238 Chromatography, Liquid 0.02794 Humans 0.01687 Humans 0.01658 Tissue Inhibitor of Metalloproteinase-1 0.01598 Reproducibility of Results 0.01464 Chemokines 0.01315 Peptide Mapping 0.00926 Chemokines, CC 0.01245 Trypsin 0.00782 Chemotaxis 0.01091 Molecular Weight 0.00707 Stromal Cells 0.01067 Protein Array Analysis 0.00558 Proteoglycans 0.01037 Animals 0.00518 Fibronectins 0.00997 Chromatography, Ion Exchange 0.00488 Animals 0.00958 Peptides 0.00438 Tissue Inhibitor of Metalloproteinase-2 0.00918 Chromatography, Affinity 0.00393 Gene Expression Regulation, Enzymologic 0.00675 Hydrogen-Ion Concentration 0.00388 TOPIC 171 0.00218 TOPIC 172 0.00217 surfac 0.09636 metabol 0.14451 implant 0.03022 enzym 0.05918 forc 0.02719 metabolit 0.03514 composit 0.02307 cytochrom 0.03209 devic 0.01989 p450 0.03110 measur 0.01280 dehydrogenas 0.02735 properti 0.01220 activ 0.02013 contact 0.01185 cyp2d6 0.01545 film 0.01043 human 0.01516 place 0.00979 liver 0.01505 depth 0.00885 cyp3a4 0.01381 layer 0.00870 microsom 0.01371 strength 0.00825 cyp1a1 0.01332 remov 0.00814 respect 0.01214 resin 0.00813 substrat 0.01164 prepar 0.00808 cyp2c9 0.01121 bond 0.00782 drug 0.01120 dentin 0.00741 cyp3a5 0.01091 techniqu 0.00730 cyp 0.01076 attach 0.00728 cyp1a2 0.00994 Surface Properties 0.03919 Cytochrome P-450 Enzyme System 0.09175 Materials Testing 0.03287 Aryl Hydrocarbon Hydroxylases 0.05737 Stress, Mechanical 0.02991 Humans 0.03262 Humans 0.02644 Microsomes, Liver 0.03025 Elasticity 0.01877 Cytochrome P-450 CYP2D6 0.02601 Microscopy, Atomic Force 0.01791 Liver 0.02299 Equipment Design 0.01681 Isoenzymes 0.02208 Biomechanics 0.01656 Glucuronosyltransferase 0.02198 Microscopy, Electron, Scanning 0.01420 Kinetics 0.02077 Composite Resins 0.01335 Mixed Function Oxygenases 0.01568 Animals 0.01034 Pharmacogenetics 0.01472 Tensile Strength 0.01034 Cytochrome P-450 CYP1A1 0.01427 Nanotechnology 0.00813 Biotransformation 0.00938 Biocompatible Materials 0.00672 Cytochrome P-450 CYP1A2 0.00887 Titanium 0.00662 Recombinant Proteins 0.00862 Analysis of Variance 0.00657 Pharmaceutical Preparations 0.00791 Microfluidics 0.00652 Hydroxylation 0.00776 Dental Bonding 0.00647 Xenobiotics 0.00751 Phase Transition 0.00627 Oxidoreductases, N-Demethylating 0.00691 Equipment Failure Analysis 0.00592 Animals 0.00686 TOPIC 173 0.00217 TOPIC 174 0.00217 genet 0.08937 thyroid 0.12409 trait 0.05791 hormon 0.05965 environment 0.05064 neuroblastoma 0.04698 influenc 0.05054 pituitari 0.03483 twin 0.04306 carcinoma 0.03375 cystic 0.03527 ret 0.02524 factor 0.03283 papillari 0.02469 fibrosi 0.03098 ptc 0.01947 herit 0.02966 adenoma 0.01847 pair 0.02827 follicular 0.01469 studi 0.02754 studi 0.01229 correl 0.02613 nodul 0.01218 cftr 0.02348 normal 0.01097 environ 0.01876 hypothyroid 0.01078 varianc 0.01862 tsh 0.01061 variat 0.01625 investig 0.01047 conduct 0.01614 prl 0.00935 compon 0.01558 braf 0.00931 common 0.01469 medullari 0.00905 phenotyp 0.01408 alter 0.00890 Cystic Fibrosis 0.07317 Thyroid Neoplasms 0.12862 Cystic Fibrosis Transmembrane Conductance Regulator 0.06080 Neuroblastoma 0.06664 Humans 0.05135 Thyroid Gland 0.05055 Environment 0.04206 Carcinoma, Papillary 0.03678 Twins, Monozygotic 0.04120 Adenoma 0.02591 Phenotype 0.03302 Oncogene Proteins 0.02434 Twins, Dizygotic 0.03186 Proto-Oncogene Proteins c-ret 0.02312 Diseases in Twins 0.02863 Pituitary Neoplasms 0.02145 Quantitative Trait, Heritable 0.02091 Receptor Protein-Tyrosine Kinases 0.01968 Variation (Genetics) 0.01808 Hypothyroidism 0.01811 Adult 0.01803 Iodine Radioisotopes 0.01705 Analysis of Variance 0.01616 Humans 0.01634 Twins 0.01464 Thyrotropin 0.01508 Genetic Predisposition to Disease 0.01368 Pituitary Gland 0.01336 Models, Genetic 0.01096 Proto-Oncogene Proteins B-raf 0.01275 Adolescent 0.00924 Adenocarcinoma, Follicular 0.01270 Genotype 0.00712 Carcinoma, Medullary 0.01184 Social Environment 0.00697 Human Growth Hormone 0.01154 Twin Studies 0.00692 Thyroxine 0.01149 Middle Aged 0.00560 Thyroid Hormones 0.01133 TOPIC 175 0.00216 TOPIC 176 0.00215 fusion 0.12615 smoke 0.07932 fluoresc 0.11736 hypoxia 0.05755 protein 0.11264 hif-1alpha 0.03829 green 0.05718 increas 0.02911 gfp 0.04270 hypox 0.02737 report 0.02928 tobacco 0.02561 fuse 0.02552 smoker 0.02492 egfp 0.02149 factor 0.02394 enhanc 0.01842 hypoxia-induc 0.02298 dye 0.01811 cigarett 0.02197 demonstr 0.01721 glutathion 0.02046 live 0.01535 gst 0.01994 result 0.01319 associ 0.01965 construct 0.01300 studi 0.01886 observ 0.01181 gstm1 0.01821 label 0.01129 gstp1 0.01743 contain 0.01101 vhl 0.01719 transfer 0.01092 nicotin 0.01686 microscopi 0.00980 null 0.01653 allow 0.00889 s-transferas 0.01605 Green Fluorescent Proteins 0.21758 Smoking 0.11249 Recombinant Fusion Proteins 0.10145 Glutathione Transferase 0.08925 Microscopy, Fluorescence 0.04946 Hypoxia-Inducible Factor 1, alpha Subunit 0.08553 Fluorescent Dyes 0.03834 Cell Hypoxia 0.05372 Luminescent Proteins 0.02163 Anoxia 0.04806 Genes, Reporter 0.02072 Transcription Factors 0.04755 Fluorescence Resonance Energy Transfer 0.01914 Hypoxia-Inducible Factor 1 0.03853 Spectrometry, Fluorescence 0.01696 Isoenzymes 0.02334 Microscopy, Confocal 0.01696 Oxygen 0.02217 Cell Fusion 0.01092 Nuclear Proteins 0.02161 Fluorescence 0.00894 Glutathione S-Transferase pi 0.02146 Animals 0.00604 Von Hippel-Lindau Tumor Suppressor Protein 0.01616 Cell Line 0.00503 Ubiquitin-Protein Ligases 0.01055 Plasmids 0.00462 Nicotine 0.01014 Flow Cytometry 0.00452 Tumor Suppressor Proteins 0.00887 Humans 0.00401 Smoking Cessation 0.00866 Transfection 0.00401 Tobacco 0.00683 Bacterial Proteins 0.00371 DNA-Binding Proteins 0.00663 Membrane Fusion 0.00366 Hippel-Lindau Disease 0.00622 Cricetinae 0.00335 Tobacco Use Disorder 0.00596 TOPIC 177 0.00214 TOPIC 178 0.00212 defici 0.15015 cell 0.25164 adren 0.03836 death 0.17979 anemia 0.03780 surviv 0.04582 malaria 0.02874 apoptosi 0.04348 parasit 0.02335 protect 0.03268 plasmodium 0.01874 caus 0.02801 mosquito 0.01602 induc 0.02013 falciparum 0.01568 cellular 0.01981 erythrocyt 0.01449 program 0.01626 cortisol 0.01413 lead 0.01549 erythropoietin 0.01399 bdnf 0.01344 caus 0.01348 apoptot 0.01326 g6pd 0.01293 arsen 0.01279 insuffici 0.01203 trigger 0.01083 adrenocort 0.01163 prevent 0.00978 acth 0.01122 pathwai 0.00928 anaemia 0.01076 cd95 0.00908 epo 0.00970 kill 0.00874 anophel 0.00943 role 0.00841 develop 0.00876 mechan 0.00839 Plasmodium falciparum 0.04307 Apoptosis 0.18049 Malaria, Falciparum 0.02716 Cell Death 0.07420 Malaria 0.02669 Cell Survival 0.06472 Humans 0.02567 Brain-Derived Neurotrophic Factor 0.01802 Anemia 0.02536 Humans 0.01791 Protozoan Proteins 0.02454 Necrosis 0.01678 Antimalarials 0.02402 Autophagy 0.01507 Animals 0.02331 Animals 0.01124 Adrenal Hyperplasia, Congenital 0.01951 Arsenicals 0.01113 Erythropoietin 0.01730 Antigens, CD95 0.01098 Hydrocortisone 0.01401 Caspases 0.01087 Anopheles 0.01314 Oxides 0.01077 Glucosephosphate Dehydrogenase Deficiency 0.01294 Signal Transduction 0.00637 Erythrocytes 0.01278 Membrane Glycoproteins 0.00559 Chloroquine 0.01268 Adaptor Proteins, Signal Transducing 0.00513 Hemoglobins 0.01135 Receptors, Tumor Necrosis Factor 0.00502 Adrenal Glands 0.01027 Mice 0.00476 Infant 0.00955 Cell Line, Tumor 0.00404 Insect Vectors 0.00862 Intracellular Signaling Peptides and Proteins 0.00357 Steroid 21-Hydroxylase 0.00806 Models, Biological 0.00347 TOPIC 179 0.00210 TOPIC 180 0.00210 male 0.20442 molecular 0.18437 femal 0.18718 provid 0.09316 sex 0.07547 understand 0.07871 sexual 0.05037 insight 0.05765 reproduct 0.03877 mechan 0.04333 mate 0.03868 basi 0.04243 offspr 0.02716 biolog 0.04069 gender 0.01711 new 0.03509 gonad 0.01218 biologi 0.03386 patern 0.01213 better 0.02217 steril 0.01204 gain 0.02053 determin 0.01078 recent 0.01531 dimorph 0.00853 includ 0.01441 transmit 0.00801 underli 0.01416 sry 0.00698 process 0.01199 success 0.00637 model 0.01185 choic 0.00633 defin 0.01170 cross 0.00597 pathogenesi 0.01133 ratio 0.00595 cellular 0.00955 partner 0.00557 physiolog 0.00850 Sex Factors 0.10113 Animals 0.14722 Reproduction 0.07831 Humans 0.12169 Sex Characteristics 0.05283 Molecular Biology 0.02093 Animals 0.03037 Models, Biological 0.02072 Fertility 0.01969 Mutation 0.01569 Sex Ratio 0.01824 Mice 0.01517 Sex Determination (Genetics) 0.01719 Signal Transduction 0.01318 X Chromosome 0.01407 Gene Expression Regulation 0.00654 Y Chromosome 0.01151 Disease Models, Animal 0.00555 Crosses, Genetic 0.01136 Transcription Factors 0.00324 Body Size 0.01016 DNA-Binding Proteins 0.00283 Analysis of Variance 0.01000 Models, Molecular 0.00283 Humans 0.00922 Neoplasms 0.00272 Chromosomes, Human, Y 0.00875 Oligonucleotide Array Sequence Analysis 0.00246 Sexual Behavior 0.00740 Gene Expression 0.00246 Sex Differentiation 0.00667 Models, Genetic 0.00214 Dosage Compensation, Genetic 0.00646 Protein Binding 0.00209 Testis 0.00573 Oncogenes 0.00209 Hermaphroditism 0.00563 Genomics 0.00204 Age Factors 0.00563 Phenotype 0.00188 TOPIC 181 0.00205 TOPIC 182 0.00204 prevent 0.07797 class 0.18114 cox-2 0.07754 mhc 0.06486 effect 0.07096 molecul 0.06408 inhibitor 0.03870 antigen 0.04631 reduc 0.03152 hla 0.04529 studi 0.03094 major 0.03737 chemoprevent 0.02774 complex 0.03142 inhibit 0.02703 allel 0.02943 increas 0.02572 present 0.02386 suggest 0.02568 human 0.02255 treatment 0.02493 histocompat 0.02164 agent 0.02009 leukocyt 0.01569 decreas 0.01963 natur 0.01421 potenti 0.01954 drb1 0.01364 select 0.01770 specif 0.01332 carcinogenesi 0.01675 type 0.01260 cyclooxygenase-2 0.01624 kir 0.00959 investig 0.01509 hla-drb1 0.00921 prostaglandin 0.01430 recogn 0.00887 drug 0.01357 killer 0.00746 Prostaglandin-Endoperoxide Synthases 0.11424 Histocompatibility Antigens Class I 0.07121 Cyclooxygenase 2 0.10943 HLA-DR Antigens 0.05400 Membrane Proteins 0.08127 HLA Antigens 0.04803 Cyclooxygenase Inhibitors 0.06043 Histocompatibility Antigens Class II 0.03991 Anti-Inflammatory Agents, Non-Steroidal 0.04317 Major Histocompatibility Complex 0.03738 Cyclooxygenase 2 Inhibitors 0.03238 Alleles 0.03507 Sulfonamides 0.02559 Receptors, Immunologic 0.03060 Dinoprostone 0.02549 Humans 0.02808 Anticarcinogenic Agents 0.02057 Genes, MHC Class I 0.02754 Aspirin 0.01795 HLA-DQ Antigens 0.02662 Pyrazoles 0.01544 Antigen Presentation 0.02404 Chemoprevention 0.01544 HLA-B Antigens 0.02195 Cyclooxygenase 1 0.00625 Genes, MHC Class II 0.01979 Sulfones 0.00502 Killer Cells, Natural 0.01904 Animals 0.00486 Histocompatibility Testing 0.01710 Arachidonic Acid 0.00481 HLA-A Antigens 0.01549 Nitrobenzenes 0.00465 Molecular Sequence Data 0.01033 Humans 0.00433 Lectins, C-Type 0.00597 Lactones 0.00395 HLA-C Antigens 0.00543 Gene Expression Regulation, Enzymologic 0.00337 Terminology 0.00522 TOPIC 183 0.00202 TOPIC 184 0.00202 light 0.09999 assai 0.11116 field 0.05467 quantit 0.08704 puls 0.02829 detect 0.07982 laser 0.02391 pcr 0.07277 intens 0.02311 real-tim 0.04687 electr 0.01559 method 0.04411 blue 0.01550 develop 0.02657 shed 0.01535 sampl 0.02618 measur 0.01388 quantif 0.02079 power 0.01384 monitor 0.01874 energi 0.01367 quantifi 0.01730 exposur 0.01254 multiplex 0.01636 effect 0.01158 determin 0.01501 red 0.01143 measur 0.01449 spectral 0.01136 analysi 0.01441 time 0.01117 rapid 0.01241 wave 0.01073 qualit 0.01173 mobil 0.01070 valid 0.01005 excit 0.01032 sensit 0.00950 frequenc 0.00958 rt-pcr 0.00925 Light 0.11003 Polymerase Chain Reaction 0.17630 Electromagnetic Fields 0.04092 Sensitivity and Specificity 0.09491 Lasers 0.02792 Reproducibility of Results 0.05014 Dose-Response Relationship, Radiation 0.02531 Reverse Transcriptase Polymerase Chain Reaction 0.04851 Cellular Phone 0.02315 Humans 0.04482 Humans 0.01529 DNA Primers 0.01633 Time Factors 0.01480 DNA Probes 0.00852 Photochemistry 0.01404 Time Factors 0.00749 Microwaves 0.01377 Fluorescent Dyes 0.00727 Chlorophyll 0.01203 Nucleic Acid Amplification Techniques 0.00602 Radiation Dosage 0.01165 Reference Standards 0.00559 Photosynthesis 0.01100 Taq Polymerase 0.00543 Photosystem II Protein Complex 0.01046 Base Sequence 0.00526 Spectrum Analysis 0.00721 Gene Dosage 0.00402 Animals 0.00645 Reagent Kits, Diagnostic 0.00374 Photosensitizing Agents 0.00575 Animals 0.00364 Radio Waves 0.00575 Fluorescence 0.00364 Laser Therapy, Low-Level 0.00564 Oligonucleotide Probes 0.00255 Spectrophotometry 0.00537 Organic Chemicals 0.00244 Electricity 0.00537 Infant 0.00222 TOPIC 185 0.00198 TOPIC 186 0.00197 treatment 0.48487 trial 0.10525 treat 0.13594 random 0.07669 effect 0.06108 studi 0.04215 therapi 0.05712 arm 0.03928 improv 0.04671 treatment 0.03115 untreat 0.02477 clinic 0.03014 follow 0.01687 improv 0.02907 efficaci 0.01279 compar 0.02638 pretreat 0.01115 efficaci 0.02495 reduct 0.00877 group 0.02206 therapeut 0.00706 placebo 0.02204 option 0.00622 baselin 0.02109 initi 0.00557 receiv 0.02062 prior 0.00498 safeti 0.01951 pre-treat 0.00485 advers 0.01811 modal 0.00479 effect 0.01736 achiev 0.00437 assign 0.01624 post-treat 0.00393 versu 0.01485 benefici 0.00387 design 0.01483 evalu 0.00383 event 0.01463 Humans 0.11995 Treatment Outcome 0.07278 Treatment Outcome 0.10008 Double-Blind Method 0.06832 Time Factors 0.02031 Humans 0.06765 Antineoplastic Agents 0.01753 Randomized Controlled Trials 0.06453 Drug Therapy, Combination 0.01598 Clinical Trials 0.03812 Combined Modality Therapy 0.01309 Prospective Studies 0.01967 Drug Administration Schedule 0.00982 Placebos 0.01833 Dose-Response Relationship, Drug 0.00771 Middle Aged 0.01477 Gene Therapy 0.00588 Safety 0.01092 Antineoplastic Combined Chemotherapy Protocols 0.00577 Drug Therapy, Combination 0.01070 Adult 0.00466 Research Design 0.01064 Clinical Trials 0.00455 Drug Administration Schedule 0.01059 Follow-Up Studies 0.00372 Cross-Over Studies 0.00786 Animals 0.00344 Time Factors 0.00758 Survival Rate 0.00344 Aged 0.00652 Survival Analysis 0.00338 Multicenter Studies 0.00546 Prognosis 0.00327 Adult 0.00507 Child 0.00327 Follow-Up Studies 0.00346 Middle Aged 0.00300 Endpoint Determination 0.00346 Chemotherapy, Adjuvant 0.00283 United States 0.00340 TOPIC 187 0.00194 TOPIC 188 0.00193 central 0.11021 complex 0.35025 nervou 0.06340 subunit 0.08035 nerv 0.05605 assembl 0.06203 cns 0.04334 compon 0.03813 spinal 0.03856 form 0.03579 peripher 0.03213 recruit 0.03160 cord 0.03001 requir 0.02538 axon 0.02815 format 0.02270 neuropathi 0.02558 interact 0.02092 myelin 0.02280 essenti 0.01878 csf 0.01660 mediat 0.01008 oligodendrocyt 0.01447 biochem 0.01003 motor 0.01336 heterodim 0.00927 autonom 0.01216 compos 0.00891 involv 0.01212 propos 0.00854 demyelin 0.01162 contain 0.00796 sensori 0.01019 function 0.00794 brain 0.00940 stabl 0.00738 find 0.00938 reconstitut 0.00693 patholog 0.00933 step 0.00685 Spinal Cord 0.04559 Protein Subunits 0.07673 Central Nervous System 0.03752 Multiprotein Complexes 0.05652 Axons 0.03267 Protein Binding 0.04739 Brain 0.02951 Saccharomyces cerevisiae Proteins 0.03246 Oligodendroglia 0.02674 Saccharomyces cerevisiae 0.02576 Myelin Sheath 0.02465 Dimerization 0.02134 Charcot-Marie-Tooth Disease 0.01811 Macromolecular Substances 0.01867 Humans 0.01625 Models, Biological 0.01748 Demyelinating Diseases 0.01585 Protein Structure, Tertiary 0.01118 Peripheral Nervous System Diseases 0.01461 Humans 0.01095 Neural Conduction 0.01405 Animals 0.00846 Myelin Proteins 0.01377 Mutation 0.00840 Central Nervous System Neoplasms 0.01377 Carrier Proteins 0.00777 Multiple Sclerosis 0.01117 Nuclear Proteins 0.00755 Animals 0.01010 Models, Molecular 0.00658 Schwann Cells 0.00959 Immunoprecipitation 0.00653 Sciatic Nerve 0.00818 Ribonucleoproteins, Small Nuclear 0.00556 Nerve Regeneration 0.00790 Cell Cycle Proteins 0.00533 Nerve Tissue Proteins 0.00773 Hela Cells 0.00465 Encephalomyelitis, Autoimmune, Experimental 0.00750 Time Factors 0.00420 TOPIC 189 0.00193 TOPIC 190 0.00191 delet 0.15245 phenotyp 0.31310 glioma 0.07522 character 0.06710 brain 0.06895 characterist 0.04929 glioblastoma 0.04657 featur 0.04500 malign 0.03504 distinct 0.04287 includ 0.02388 similar 0.03647 grade 0.02255 displai 0.02947 meningioma 0.02224 exhibit 0.02500 studi 0.02100 suggest 0.01817 astrocytoma 0.02084 correl 0.01758 suggest 0.01618 morpholog 0.01672 gbm 0.01466 identifi 0.01575 indic 0.01407 subset 0.01569 progress 0.01399 heterogen 0.01509 investig 0.01213 overlap 0.01476 multiform 0.01057 lack 0.01441 frequent 0.01056 resembl 0.01379 temozolomid 0.01024 uniqu 0.01352 common 0.01018 defin 0.01221 observ 0.00952 describ 0.01161 Brain Neoplasms 0.20385 Phenotype 0.53663 Glioma 0.12011 Genotype 0.00614 Glioblastoma 0.09301 Humans 0.00350 Gene Deletion 0.05755 Animals 0.00258 Astrocytoma 0.04051 Immunohistochemistry 0.00224 Brain 0.02994 Child 0.00189 Meningioma 0.02341 Models, Biological 0.00178 Meningeal Neoplasms 0.01665 Biological Markers 0.00178 Oligodendroglioma 0.01375 Models, Genetic 0.00155 Dacarbazine 0.01028 Gene Expression 0.00155 Sequence Deletion 0.00710 Adult 0.00144 Humans 0.00523 Amino Acid Sequence 0.00132 Chromosome Deletion 0.00466 Membrane Proteins 0.00132 Chromosomes, Human, Pair 22 0.00420 Recombinant Fusion Proteins 0.00132 Antineoplastic Agents, Alkylating 0.00403 DNA 0.00126 Central Nervous System Neoplasms 0.00403 Base Sequence 0.00121 Loss of Heterozygosity 0.00381 DNA Primers 0.00121 Magnetic Resonance Imaging 0.00352 Proto-Oncogene Proteins 0.00121 Adult 0.00295 Signal Transduction 0.00121 Chromosomes, Human, Pair 1 0.00273 Cells, Cultured 0.00115 TOPIC 191 0.00188 TOPIC 192 0.00182 dose 0.15508 loss 0.16734 administr 0.06383 hear 0.06380 effect 0.03597 ear 0.03822 toler 0.03444 threshold 0.02636 administ 0.02977 inner 0.02293 infus 0.02631 deaf 0.02096 oral 0.02473 auditori 0.01811 intraven 0.02391 middl 0.01668 pharmacokinet 0.02106 impair 0.01529 hour 0.02018 vestibular 0.01491 receiv 0.01799 cochlear 0.01360 studi 0.01707 studi 0.01326 follow 0.01569 hair 0.01291 given 0.01562 canal 0.01287 singl 0.01460 sensorineur 0.01214 drug 0.01390 caus 0.01191 toxic 0.01326 bilater 0.01147 dosag 0.01317 find 0.01018 dai 0.01265 acoust 0.00929 evalu 0.01161 sound 0.00904 Dose-Response Relationship, Drug 0.13481 Hearing Loss, Sensorineural 0.06458 Administration, Oral 0.05543 Deafness 0.04047 Area Under Curve 0.03621 Hearing Loss 0.03006 Drug Administration Schedule 0.03189 Cochlea 0.02934 Infusions, Intravenous 0.01992 Humans 0.02928 Injections, Intravenous 0.01717 Audiometry, Pure-Tone 0.02483 Tissue Distribution 0.01560 Auditory Threshold 0.02201 Time Factors 0.01139 Ear, Inner 0.01882 Metabolic Clearance Rate 0.01092 Acoustic Stimulation 0.01834 Humans 0.01063 Evoked Potentials, Auditory, Brain Stem 0.01082 Biological Availability 0.00946 Hearing Loss, Sudden 0.00908 Half-Life 0.00899 Cochlear Implants 0.00884 Drug Therapy, Combination 0.00602 Hair Cells 0.00854 Injections, Subcutaneous 0.00555 Audiometry 0.00824 Animals 0.00543 Hearing 0.00788 Treatment Outcome 0.00491 Tinnitus 0.00782 Drug Interactions 0.00444 Connexins 0.00764 Recombinant Proteins 0.00350 Middle Aged 0.00728 Antineoplastic Agents 0.00339 Hearing Disorders 0.00716 Cross-Over Studies 0.00327 Noise 0.00691 TOPIC 193 0.00181 TOPIC 194 0.00180 diseas 0.06435 resist 0.35475 alzheimer 0.04611 suscept 0.06345 delta 0.04043 confer 0.04318 imprint 0.03708 toxin 0.03030 deposit 0.03687 antibiot 0.03027 amyloid 0.02948 isol 0.02658 tau 0.02420 acquir 0.02275 dementia 0.02282 determin 0.01613 suggest 0.02101 select 0.01526 abeta 0.01838 carri 0.01117 associ 0.01639 sensit 0.00917 patholog 0.01632 clinic 0.00909 brain 0.01451 indic 0.00895 precursor 0.01336 strain 0.00846 app 0.01235 mic 0.00739 genistein 0.01173 major 0.00727 includ 0.01133 highli 0.00703 report 0.01118 caus 0.00692 caus 0.01059 test 0.00691 major 0.01013 presenc 0.00647 Alzheimer Disease 0.16167 Anti-Bacterial Agents 0.09873 Amyloid beta-Protein 0.05015 Microbial Sensitivity Tests 0.07829 Genomic Imprinting 0.04238 Drug Resistance, Bacterial 0.06625 Brain 0.03728 Drug Resistance 0.03206 tau Proteins 0.03048 beta-Lactamases 0.01758 Dementia 0.02726 Drug Resistance, Neoplasm 0.01636 Amyloid beta-Protein Precursor 0.02604 Drug Resistance, Multiple, Bacterial 0.01594 Amyloid 0.01609 Immunity, Natural 0.01533 Amyloidosis 0.01609 Bacterial Proteins 0.01454 Aged 0.01421 Streptococcus pneumoniae 0.01046 Membrane Proteins 0.01226 Humans 0.00955 Aged, 80 and over 0.01172 Anti-Infective Agents 0.00809 Humans 0.01135 Erythromycin 0.00700 Apolipoproteins E 0.01123 Integrons 0.00657 Aspartic Endopeptidases 0.01099 Macrolides 0.00639 Prealbumin 0.01087 Bacterial Toxins 0.00560 Neurodegenerative Diseases 0.01038 Enterococcus faecium 0.00560 Endopeptidases 0.00929 Ciprofloxacin 0.00499 Peptide Fragments 0.00704 Botulinum Toxin Type A 0.00493 Senile Plaques 0.00680 Genes, Bacterial 0.00487 TOPIC 195 0.00177 TOPIC 196 0.00175 cervic 0.09022 screen 0.26659 hpv 0.06061 program 0.04943 human 0.05165 identifi 0.03891 uterin 0.02840 test 0.03774 papillomaviru 0.02347 detect 0.03336 cytolog 0.02079 circadian 0.02695 type 0.02003 newborn 0.02492 studi 0.01915 clock 0.02082 neoplasia 0.01826 includ 0.01993 lesion 0.01586 programm 0.01810 squamou 0.01467 surveil 0.01473 cin 0.01438 perform 0.01382 posit 0.01402 oscil 0.01323 intraepitheli 0.01371 rhythm 0.01320 associ 0.01309 earli 0.01034 case 0.01235 period 0.00937 high-risk 0.01234 recommend 0.00890 cervix 0.01224 establish 0.00764 hpv16 0.01078 carri 0.00752 detect 0.01053 posit 0.00691 Uterine Cervical Neoplasms 0.15218 Mass Screening 0.11623 Papillomaviridae 0.12564 Circadian Rhythm 0.07293 Papillomavirus Infections 0.07516 Infant, Newborn 0.06034 Oncogene Proteins, Viral 0.03969 Neonatal Screening 0.05595 Cervical Intraepithelial Neoplasia 0.03950 Genetic Screening 0.02356 DNA, Viral 0.03938 Humans 0.02318 Cervix Uteri 0.02115 Biological Clocks 0.01454 Vaginal Smears 0.01984 Mammography 0.01122 Humans 0.01780 Phenylketonurias 0.01053 Uterine Neoplasms 0.01699 Sensitivity and Specificity 0.00858 Carcinoma, Squamous Cell 0.01346 United States 0.00695 Adult 0.01277 Metabolism, Inborn Errors 0.00583 Uterus 0.01005 Risk Factors 0.00576 Leiomyoma 0.00707 Early Diagnosis 0.00508 Middle Aged 0.00552 Infant 0.00495 Polymerase Chain Reaction 0.00552 Program Evaluation 0.00482 Uterine Cervical Dysplasia 0.00540 Time Factors 0.00470 Biopsy 0.00515 False Positive Reactions 0.00457 Tumor Virus Infections 0.00502 Melatonin 0.00445 Precancerous Conditions 0.00477 Occult Blood 0.00439 TOPIC 197 0.00173 TOPIC 198 0.00173 method 0.21572 hybrid 0.18784 techniqu 0.06396 fish 0.12125 approach 0.04292 situ 0.10387 allow 0.03266 probe 0.09411 simpl 0.03107 detect 0.06388 develop 0.02457 fluoresc 0.06117 appli 0.02447 label 0.02339 applic 0.02397 analysi 0.02301 rapid 0.02149 techniqu 0.01675 effici 0.01925 perform 0.01278 describ 0.01571 reveal 0.00975 tool 0.01521 demonstr 0.00882 base 0.01416 intens 0.00786 advantag 0.01252 hybridis 0.00757 provid 0.01186 specif 0.00753 valid 0.01080 high 0.00732 reliabl 0.01074 confirm 0.00699 power 0.00998 combin 0.00688 new 0.00932 order 0.00670 altern 0.00912 slide 0.00651 Humans 0.10990 In Situ Hybridization, Fluorescence 0.15685 Reproducibility of Results 0.03942 In Situ Hybridization 0.12452 Sensitivity and Specificity 0.02757 Nucleic Acid Hybridization 0.04235 Genetic Techniques 0.01280 Fishes 0.03772 Time Factors 0.01115 DNA Probes 0.03386 Animals 0.00773 Oligonucleotide Probes 0.01953 Polymerase Chain Reaction 0.00754 Animals 0.01217 Algorithms 0.00602 Hybridization, Genetic 0.00856 DNA 0.00380 Fluorescent Dyes 0.00748 Equipment Design 0.00323 Molecular Sequence Data 0.00685 Mice 0.00317 Humans 0.00653 Base Sequence 0.00304 DNA 0.00431 Proteins 0.00241 Molecular Probes 0.00412 Microscopy, Fluorescence 0.00241 Fish Diseases 0.00399 DNA Primers 0.00235 Chromosomes, Mammalian 0.00380 Fluorescent Dyes 0.00235 Oryzias 0.00374 Chromatography, High Pressure Liquid 0.00228 Radiation Hybrid Mapping 0.00317 Computer Simulation 0.00228 Base Sequence 0.00273 Data Interpretation, Statistical 0.00222 DNA Primers 0.00273 Software 0.00209 Oncorhynchus mykiss 0.00273 TOPIC 199 0.00171 TOPIC 200 0.00168 studi 0.04710 subject 0.24557 criteria 0.04695 control 0.09451 data 0.04600 healthi 0.09383 publish 0.03354 frequenc 0.09053 literatur 0.03311 carrier 0.04317 definit 0.02750 compar 0.03326 systemat 0.02735 studi 0.02937 review 0.02649 differ 0.02376 search 0.02427 higher 0.02126 includ 0.02238 volunt 0.01872 guidelin 0.01900 signific 0.01681 articl 0.01764 group 0.01432 base 0.01634 methods 0.01412 meta-analysi 0.01632 determin 0.01133 evid 0.01624 normal 0.01043 current 0.01618 respect 0.01018 avail 0.01577 conclusions 0.00953 recommend 0.01532 individu 0.00952 assess 0.01365 similar 0.00874 refer 0.01276 objective 0.00840 Humans 0.14466 Adult 0.16857 Practice Guidelines 0.02011 Case-Control Studies 0.07168 Evidence-Based Medicine 0.01954 Middle Aged 0.03884 Research Design 0.01921 Globins 0.03408 Meta-Analysis 0.01671 Humans 0.02587 Terminology 0.01356 beta-Thalassemia 0.02470 United States 0.01266 Reference Values 0.01948 Randomized Controlled Trials 0.00983 Anemia, Sickle Cell 0.01753 Periodicals 0.00752 Hemoglobins, Abnormal 0.01310 Publishing 0.00713 Adolescent 0.01140 Risk Assessment 0.00713 alpha-Thalassemia 0.01023 Reproducibility of Results 0.00559 Aged 0.00873 Guidelines 0.00508 Heterozygote 0.00860 Review Literature 0.00488 Thailand 0.00671 Risk Factors 0.00469 Thalassemia 0.00502 Animals 0.00443 Hemoglobins 0.00463 Sensitivity and Specificity 0.00405 Child 0.00378 Prognosis 0.00392 Hemoglobinopathies 0.00371 Publication Bias 0.00386 Aged, 80 and over 0.00365 Clinical Trials 0.00373 Carrier State 0.00345 TOPIC 201 0.00168 TOPIC 202 0.00167 intestin 0.10683 blood 0.29111 small 0.07839 peripher 0.09523 studi 0.04088 pressur 0.06994 parkinson 0.03970 red 0.02745 diseas 0.03188 mononuclear 0.02194 suggest 0.02032 circul 0.02157 bowel 0.01949 lymphocyt 0.02062 dopamin 0.01604 pbmc 0.01787 alpha-synuclein 0.01565 transfus 0.01709 enter 0.01428 count 0.01663 parkin 0.01350 healthi 0.01611 patch 0.01349 leukocyt 0.01400 mucos 0.01343 donor 0.01200 caus 0.01247 studi 0.01171 number 0.01157 rbc 0.01048 dopaminerg 0.01136 methods 0.00993 gut 0.01060 mean 0.00970 larg 0.01034 respect 0.00892 absorpt 0.01026 mmhg 0.00837 indic 0.00941 increas 0.00823 Parkinson Disease 0.10620 Blood Pressure 0.07019 Intestinal Mucosa 0.05267 Leukocytes, Mononuclear 0.06585 Intestines 0.04321 Erythrocytes 0.03536 Synucleins 0.03864 Adult 0.03398 Intestine, Small 0.03472 Humans 0.03365 alpha-Synuclein 0.03290 Blood Transfusion 0.02300 Nerve Tissue Proteins 0.03166 Lymphocytes 0.02175 Dopamine 0.02441 Leukocytes 0.01715 Parkinsonian Disorders 0.01351 ABO Blood-Group System 0.01439 Substantia Nigra 0.01338 Hemoglobins 0.00979 Ubiquitin-Protein Ligases 0.01318 Blood Grouping and Crossmatching 0.00973 Celiac Disease 0.01149 Blood Donors 0.00848 Hirschsprung Disease 0.00927 Middle Aged 0.00815 Feces 0.00907 Blood Group Antigens 0.00736 Humans 0.00738 Heart Rate 0.00591 Levodopa 0.00731 Leukocyte Count 0.00565 Intestinal Neoplasms 0.00705 Pressure 0.00539 Oncogene Proteins 0.00607 Erythrocyte Transfusion 0.00526 Colon 0.00581 Neoplasm Circulating Cells 0.00486 Diarrhea 0.00568 Aged 0.00480 TOPIC 203 0.00165 TOPIC 204 0.00165 telomer 0.09817 standard 0.07192 telomeras 0.08271 procedur 0.04959 length 0.07632 laboratori 0.04172 human 0.05625 protocol 0.04076 senesc 0.04177 perform 0.03195 htert 0.03434 qualiti 0.02833 end 0.03356 prepar 0.02439 revers 0.02476 convent 0.02274 cap 0.02023 method 0.02126 shorten 0.01884 refer 0.02055 cellular 0.01488 improv 0.02037 cell 0.01296 evalu 0.01865 suggest 0.01287 routin 0.01624 transcriptas 0.01281 avail 0.01540 repeat 0.01171 commerci 0.01272 activ 0.01037 optim 0.01216 normal 0.00982 techniqu 0.01064 immort 0.00967 clinic 0.01049 maintain 0.00963 success 0.01044 mainten 0.00958 achiev 0.01030 Telomerase 0.18811 Humans 0.07722 Telomere 0.16211 Reproducibility of Results 0.05450 Cell Aging 0.06344 Quality Control 0.02578 DNA-Binding Proteins 0.06171 Sensitivity and Specificity 0.01932 Aging 0.01935 Reference Standards 0.01446 Humans 0.01004 Swine 0.01206 Telomere-Binding Proteins 0.00984 Laboratories 0.01086 Telomeric Repeat Binding Protein 2 0.00858 United States 0.00986 In Situ Hybridization, Fluorescence 0.00672 Calibration 0.00773 Animals 0.00598 Quality Assurance, Health Care 0.00713 Fibroblasts 0.00465 Time Factors 0.00566 Neoplasms 0.00392 Automation 0.00446 Telomeric Repeat Binding Protein 1 0.00386 Equipment Design 0.00420 Blotting, Southern 0.00379 Specimen Handling 0.00400 RNA 0.00366 United States Food and Drug Administration 0.00386 Cell Division 0.00339 Laboratory Techniques and Procedures 0.00353 Genomic Instability 0.00313 Indicators and Reagents 0.00353 beta-Galactosidase 0.00306 Pharmaceutical Preparations 0.00273 Cell Line, Transformed 0.00299 Reference Values 0.00260 DNA 0.00286 Risk Assessment 0.00260 TOPIC 205 0.00164 TOPIC 206 0.00164 growth 0.43249 famili 0.49983 factor 0.16850 member 0.17261 prolifer 0.03291 histori 0.03508 igf-i 0.03039 rel 0.02810 insulin-lik 0.02139 identifi 0.02496 fibroblast 0.01711 affect 0.02197 fgf 0.01335 belong 0.02061 grow 0.01235 superfamili 0.01779 role 0.01099 includ 0.01775 igf-1 0.00930 proband 0.01455 igf 0.00925 subfamili 0.01394 igfbp-3 0.00825 report 0.01358 igf-ii 0.00810 share 0.01030 igf-ir 0.00774 larg 0.00866 fgfr3 0.00770 first-degre 0.00739 bfgf 0.00755 unaffect 0.00712 basic 0.00747 known 0.00647 increas 0.00671 sibl 0.00607 mitogen 0.00638 describ 0.00520 hormon 0.00630 constitut 0.00399 Insulin-Like Growth Factor I 0.10652 Pedigree 0.10407 Cell Proliferation 0.06698 Family Health 0.06493 Receptors, Fibroblast Growth Factor 0.05022 Family 0.05451 Fibroblast Growth Factors 0.03025 Humans 0.04128 Fibroblast Growth Factor 2 0.02377 Genetic Predisposition to Disease 0.02705 Cell Division 0.02244 Multigene Family 0.01563 Insulin-Like Growth Factor Binding Protein 3 0.02144 Amino Acid Sequence 0.00995 Receptor, IGF Type 1 0.02104 Adult 0.00915 Receptor Protein-Tyrosine Kinases 0.01770 Age of Onset 0.00775 Growth Substances 0.01756 Middle Aged 0.00615 Insulin-Like Growth Factor II 0.01443 Siblings 0.00615 Human Growth Hormone 0.01109 Medical History Taking 0.00494 Growth Hormone 0.00888 Carrier Proteins 0.00488 Receptor, Fibroblast Growth Factor, Type 1 0.00781 Phylogeny 0.00474 Receptor, Fibroblast Growth Factor, Type 3 0.00721 Adolescent 0.00427 Growth Disorders 0.00574 Genetic Screening 0.00387 Receptor, Fibroblast Growth Factor, Type 2 0.00548 Molecular Sequence Data 0.00381 Somatomedins 0.00474 Mutation 0.00381 Humans 0.00441 Animals 0.00334 Recombinant Proteins 0.00381 Child 0.00334 TOPIC 207 0.00164 TOPIC 208 0.00161 base 0.09118 transport 0.17399 pair 0.06703 uptak 0.06543 dna 0.04689 bile 0.02597 nucleotid 0.04052 function 0.01944 incorpor 0.03021 salt 0.01791 oligonucleotid 0.02187 exchang 0.01762 contain 0.02177 biliari 0.01707 strand 0.01783 membran 0.01663 sequenc 0.01541 duct 0.01640 duplex 0.01429 accumul 0.01492 effici 0.01395 abc 0.01432 thymidin 0.01386 efflux 0.01127 complementari 0.01365 cellular 0.01095 templat 0.01233 indic 0.01049 nucleosid 0.01218 suggest 0.01040 mismatch 0.01140 pump 0.01038 site 0.01078 intracellular 0.01003 guanin 0.01076 mediat 0.00924 end 0.01070 increas 0.00916 analog 0.01060 barrier 0.00853 DNA 0.06930 Biological Transport 0.08047 Oligonucleotides 0.04577 Membrane Transport Proteins 0.06585 Base Pairing 0.03787 ATP-Binding Cassette Transporters 0.05850 Base Sequence 0.03586 Cation Transport Proteins 0.02102 Guanine 0.03023 Symporters 0.02102 Nucleotides 0.02192 Animals 0.01898 Base Pair Mismatch 0.01776 Kinetics 0.01374 Nucleic Acid Conformation 0.01743 Cell Membrane 0.01313 Templates, Genetic 0.01280 Bile Acids and Salts 0.00939 Oligodeoxyribonucleotides 0.01260 Hydrogen-Ion Concentration 0.00898 DNA Adducts 0.01186 Humans 0.00755 DNA Primers 0.01052 Aquaporins 0.00748 Nucleosides 0.00804 Biological Transport, Active 0.00741 Hypoxanthine Phosphoribosyltransferase 0.00717 Sodium-Hydrogen Antiporter 0.00707 Kinetics 0.00684 Bile Duct Neoplasms 0.00660 Humans 0.00630 Cholestasis 0.00565 Thymidine 0.00596 Glycerol 0.00558 Deoxyguanosine 0.00590 Protons 0.00517 DNA-Directed DNA Polymerase 0.00556 Sodium Chloride 0.00483 Adenine 0.00556 Ion Transport 0.00435 TOPIC 209 0.00159 TOPIC 210 0.00156 blot 0.09673 peptid 0.22616 western 0.08512 modifi 0.08535 flow 0.08462 modif 0.06250 analysi 0.06581 conjug 0.03045 assai 0.06570 synthet 0.02898 cytometri 0.04288 deriv 0.02082 determin 0.03649 specif 0.02016 methods 0.02888 nativ 0.02015 detect 0.02628 tea 0.01633 stain 0.02544 demonstr 0.01608 assess 0.01918 molecul 0.01480 analyz 0.01815 displai 0.01416 examin 0.01728 novel 0.01297 confirm 0.01689 attach 0.01083 northern 0.01687 recognit 0.01003 conclusions 0.01643 target 0.01002 evalu 0.01484 egcg 0.00973 trail 0.01415 correspond 0.00947 human 0.01388 design 0.00940 measur 0.01314 vivo 0.00912 Flow Cytometry 0.19806 Peptides 0.18532 Blotting, Western 0.15252 Peptide Fragments 0.05437 Membrane Glycoproteins 0.00937 Amino Acid Sequence 0.03545 Tumor Necrosis Factor-alpha 0.00923 Oligopeptides 0.03181 Apoptosis Regulatory Proteins 0.00854 SUMO-1 Protein 0.02011 Humans 0.00847 Protein Processing, Post-Translational 0.01759 Enzyme-Linked Immunosorbent Assay 0.00806 Catechin 0.01724 Immunohistochemistry 0.00482 Peptide Library 0.01352 Cell Survival 0.00468 Tea 0.01044 Fluorescent Antibody Technique 0.00420 Molecular Sequence Data 0.01037 Cell Separation 0.00406 Animals 0.00848 Receptors, Tumor Necrosis Factor 0.00393 Humans 0.00638 Fluorescent Dyes 0.00372 Lysine 0.00357 Cell Line, Tumor 0.00324 Protein Binding 0.00329 Microscopy, Fluorescence 0.00296 Proteins 0.00329 Blotting, Northern 0.00289 Transcription Factors 0.00287 Blotting, Southern 0.00289 Mice 0.00273 Fluorescent Antibody Technique, Indirect 0.00276 Cell Line 0.00266 Cells, Cultured 0.00241 Amino Acid Motifs 0.00259 Time Factors 0.00227 Recombinant Fusion Proteins 0.00252 TOPIC 211 0.00155 TOPIC 212 0.00155 microscopi 0.06818 asthma 0.06814 electron 0.06101 studi 0.04447 morpholog 0.05469 mast 0.02581 observ 0.03713 allerg 0.02402 structur 0.03284 ige 0.02253 reveal 0.02838 associ 0.01956 microscop 0.02486 allergen 0.01939 copper 0.02207 hous 0.01875 confoc 0.01901 eosinophil 0.01648 distribut 0.01750 challeng 0.01622 appear 0.01718 signific 0.01472 ultrastructur 0.01698 atop 0.01349 transmiss 0.01666 includ 0.01220 granul 0.01493 develop 0.01204 characterist 0.01482 methods 0.01165 chang 0.01399 allergi 0.01162 metal 0.01380 test 0.01159 light 0.01256 relat 0.01104 scan 0.01223 suggest 0.01098 examin 0.01196 total 0.01062 Microscopy, Electron 0.09997 Asthma 0.14017 Microscopy, Electron, Transmission 0.07621 Immunoglobulin E 0.05530 Microscopy, Confocal 0.06359 Allergens 0.03649 Copper 0.03962 Mast Cells 0.02970 Microscopy, Electron, Scanning 0.02686 Hypersensitivity 0.02546 Zinc 0.01135 Dermatitis, Atopic 0.02044 Immunohistochemistry 0.00987 Humans 0.01917 Microscopy, Immunoelectron 0.00902 Eosinophils 0.01273 Humans 0.00804 Skin Tests 0.01266 Cadmium 0.00620 Hypersensitivity, Immediate 0.01181 Microscopy 0.00613 Child 0.01061 Animals 0.00543 Pollen 0.00919 Microscopy, Fluorescence 0.00522 Bronchial Hyperreactivity 0.00842 Cytoplasm 0.00395 Rhinitis, Allergic, Seasonal 0.00813 Crystallization 0.00331 Adult 0.00806 Nanostructures 0.00296 Ovalbumin 0.00587 Biological Markers 0.00268 Respiratory Hypersensitivity 0.00587 Fluorescent Antibody Technique 0.00254 Histamine 0.00580 Ceruloplasmin 0.00254 Rhinitis, Allergic, Perennial 0.00559 Metallothionein 0.00240 Anti-Asthmatic Agents 0.00537 TOPIC 213 0.00154 TOPIC 214 0.00149 stress 0.16357 studi 0.10433 respons 0.06657 chines 0.08466 protein 0.06385 respect 0.05398 heat 0.04395 differ 0.05290 shock 0.04056 determin 0.02867 condit 0.02866 signific 0.02811 chaperon 0.02075 examin 0.02717 hsp70 0.02038 hamster 0.02595 cellular 0.01987 china 0.02521 induc 0.01904 report 0.02422 involv 0.01800 suggest 0.02079 suggest 0.01713 includ 0.02002 increas 0.01567 investig 0.01986 level 0.01514 cho 0.01722 includ 0.01456 medicin 0.01608 physiolog 0.01417 taiwan 0.01538 hsp90 0.01380 possibl 0.01517 indic 0.01261 analyz 0.01442 starvat 0.01189 observ 0.01398 hsp 0.01135 indic 0.01322 Heat-Shock Proteins 0.08897 China 0.18839 HSP70 Heat-Shock Proteins 0.06530 Cricetinae 0.10172 Molecular Chaperones 0.04277 Asian Continental Ancestry Group 0.04572 Stress 0.03579 CHO Cells 0.04022 Heat 0.02994 Taiwan 0.03670 HSP90 Heat-Shock Proteins 0.02431 Korea 0.02393 Heat-Shock Response 0.02167 Cricetulus 0.01893 Endoplasmic Reticulum 0.01433 Mitomycin 0.01049 Stress, Psychological 0.01105 Humans 0.00866 Benzoquinones 0.01027 Drugs, Chinese Herbal 0.00653 Animals 0.00905 Phytotherapy 0.00477 Protein Folding 0.00784 Mesocricetus 0.00448 Lactams, Macrocyclic 0.00777 Singapore 0.00345 Humans 0.00734 Animals 0.00316 Adaptation, Physiological 0.00727 Tibet 0.00301 Oxidative Stress 0.00720 Plants, Medicinal 0.00250 Osmotic Pressure 0.00720 Adult 0.00220 Transcription Factors 0.00577 Medicine, Chinese Traditional 0.00220 Transcription Factor CHOP 0.00528 United States 0.00213 CCAAT-Enhancer-Binding Proteins 0.00470 Egypt 0.00205 TOPIC 215 0.00149 TOPIC 216 0.00147 ovarian 0.15423 degre 0.17461 fluid 0.05211 temperatur 0.08635 studi 0.04570 stabil 0.07343 malign 0.04367 stabl 0.04317 endometri 0.04090 min 0.03477 periton 0.02887 condit 0.02764 mesothelioma 0.01669 high 0.02047 compar 0.01657 thermal 0.01957 signific 0.01527 preserv 0.01883 epitheli 0.01466 cold 0.01669 sv40 0.01439 storag 0.01657 effus 0.01295 rel 0.01290 pleural 0.01294 determin 0.01283 potenti 0.01289 increas 0.01259 serou 0.01283 depend 0.01222 carcinoma 0.01258 low 0.01212 examin 0.01248 respect 0.01181 observ 0.01243 store 0.01151 ascit 0.01240 optim 0.01058 endometriosi 0.01217 indic 0.01009 Ovarian Neoplasms 0.30226 Temperature 0.22290 Endometrial Neoplasms 0.05522 Heat 0.06262 Mesothelioma 0.03866 Cold 0.03407 Ovary 0.02062 Time Factors 0.02438 Peritoneal Neoplasms 0.01914 Humans 0.00708 Endometriosis 0.01885 Body Temperature 0.00701 Pleural Neoplasms 0.01863 Hyperthermia, Induced 0.00671 Endometrium 0.01487 Hydrogen-Ion Concentration 0.00663 Cystadenocarcinoma, Serous 0.01355 Drug Stability 0.00567 Simian virus 40 0.00928 Enzyme Stability 0.00492 Ascites 0.00906 Animals 0.00350 Carcinoma, Endometrioid 0.00707 Kinetics 0.00335 Pleural Effusion 0.00589 Acclimatization 0.00268 Adenocarcinoma 0.00552 Culture Media 0.00201 Carcinoma 0.00552 Thermodynamics 0.00194 CA-125 Antigen 0.00545 Drug Storage 0.00186 Middle Aged 0.00457 Analysis of Variance 0.00179 Humans 0.00434 Hypothermia, Induced 0.00179 Asbestos 0.00405 Fever 0.00164 Uterine Neoplasms 0.00398 Nucleic Acid Denaturation 0.00157 TOPIC 217 0.00146 TOPIC 218 0.00144 pancreat 0.19800 chicken 0.05828 islet 0.06150 convers 0.05005 studi 0.04127 mammalian 0.04004 pancrea 0.03684 differ 0.03863 k-ra 0.02583 suggest 0.03460 increas 0.02162 bird 0.02759 develop 0.02045 egg 0.02637 adenocarcinoma 0.01916 indic 0.02413 beta-cel 0.01589 similar 0.02380 associ 0.01536 mammal 0.02287 sma 0.01342 addit 0.02106 determin 0.01304 avian 0.01811 ductal 0.01264 highli 0.01578 investig 0.01258 includ 0.01411 potenti 0.01239 high 0.01370 includ 0.01236 consist 0.01364 demonstr 0.01207 chick 0.01166 observ 0.01053 experi 0.01140 suggest 0.01031 product 0.01077 endocrin 0.01022 result 0.00986 Pancreatic Neoplasms 0.24854 Chickens 0.19104 Islets of Langerhans 0.07625 Animals 0.12518 Pancreas 0.07188 Birds 0.03019 Pancreatitis 0.05020 Chick Embryo 0.02403 Adenocarcinoma 0.02808 Poultry Diseases 0.02297 Carcinoma, Pancreatic Ductal 0.02589 Mammals 0.01574 Islets of Langerhans Transplantation 0.02235 Entamoeba histolytica 0.00700 Genes, ras 0.00851 Ovum 0.00456 Pancreatic Ducts 0.00805 Species Specificity 0.00388 Trypsin 0.00655 Influenza in Birds 0.00388 Cyclic AMP Response Element-Binding Protein 0.00580 Telangiectasia, Hereditary Hemorrhagic 0.00380 Glucagon 0.00572 Humans 0.00335 Familial Mediterranean Fever 0.00429 Time Factors 0.00319 Trypsinogen 0.00429 Coturnix 0.00319 Chronic Disease 0.00414 Influenza A virus 0.00312 Nerve Tissue Proteins 0.00384 Ducks 0.00297 RNA-Binding Proteins 0.00331 Avian Proteins 0.00274 Pancreatectomy 0.00331 Dinosaurs 0.00274 Muscular Atrophy, Spinal 0.00316 Mice 0.00228 Homeodomain Proteins 0.00309 Disease Outbreaks 0.00228 TOPIC 219 0.00142 TOPIC 220 0.00140 valu 0.12505 level 0.45785 correl 0.11850 serum 0.17370 measur 0.10671 elev 0.07232 mean 0.07404 higher 0.03645 paramet 0.04625 correl 0.03066 index 0.04452 measur 0.02512 signific 0.03334 lower 0.02452 respect 0.02291 signific 0.01370 assess 0.02231 normal 0.01336 calcul 0.02226 circul 0.01260 total 0.02114 crp 0.01105 count 0.02080 compar 0.01004 averag 0.01962 determin 0.00976 coeffici 0.01934 albumin 0.00972 determin 0.01721 elevat 0.00750 evalu 0.01577 decreas 0.00728 relationship 0.01577 healthi 0.00727 percentag 0.01478 control 0.00619 linear 0.01426 elisa 0.00612 statist 0.01395 c-reactiv 0.00490 Adult 0.04916 Biological Markers 0.07093 Humans 0.04607 Enzyme-Linked Immunosorbent Assay 0.05570 Reproducibility of Results 0.02145 C-Reactive Protein 0.02997 Middle Aged 0.01835 Humans 0.02934 Reference Values 0.01765 Middle Aged 0.01710 Regression Analysis 0.01440 Adult 0.01349 Analysis of Variance 0.01363 Case-Control Studies 0.01302 Sensitivity and Specificity 0.01355 Time Factors 0.01185 Linear Models 0.01007 Reference Values 0.01075 Predictive Value of Tests 0.00976 Aged 0.00737 Aged 0.00844 Serum Albumin 0.00447 Time Factors 0.00759 Tumor Markers, Biological 0.00432 Adolescent 0.00689 Adolescent 0.00392 Biological Markers 0.00635 Regression Analysis 0.00377 Animals 0.00503 Aged, 80 and over 0.00361 Cross-Sectional Studies 0.00496 Blood Proteins 0.00361 Aged, 80 and over 0.00488 Animals 0.00314 Prospective Studies 0.00441 Predictive Value of Tests 0.00298 Anthropometry 0.00372 Statistics, Nonparametric 0.00298 Statistics 0.00348 Sensitivity and Specificity 0.00275 TOPIC 221 0.00139 TOPIC 222 0.00139 system 0.20168 prevent 0.09368 diseas 0.08519 strategi 0.08196 autoimmun 0.07419 develop 0.04631 develop 0.04262 protect 0.04579 associ 0.02830 cost 0.04530 sle 0.02750 manag 0.02802 lupu 0.02524 potenti 0.02562 includ 0.02156 effect 0.02542 autoantibodi 0.02057 reduc 0.02323 control 0.01814 need 0.02237 involv 0.01567 benefit 0.02214 pathogenesi 0.01512 current 0.01700 erythematosu 0.01355 provid 0.01431 suscept 0.01129 avoid 0.01311 ssc 0.00951 limit 0.01249 contribut 0.00918 impact 0.01096 report 0.00887 resourc 0.01026 presenc 0.00868 burden 0.01006 possibl 0.00822 effort 0.01002 major 0.00792 intervent 0.00988 Lupus Erythematosus, Systemic 0.09163 Cost-Benefit Analysis 0.03517 Autoimmune Diseases 0.06827 Humans 0.03391 Autoantibodies 0.05694 United States 0.02762 Autoimmunity 0.03256 Health Care Costs 0.01094 Humans 0.02226 Animals 0.00598 Antibodies, Antinuclear 0.01722 Medicare 0.00543 Scleroderma, Systemic 0.01471 Costs and Cost Analysis 0.00441 Autoantigens 0.01463 Drug Costs 0.00330 Antigens, Differentiation 0.01227 Quality-Adjusted Life Years 0.00315 Antigens, CD 0.01219 Time Factors 0.00299 Graves Disease 0.00897 Models, Biological 0.00291 Lupus Nephritis 0.00747 Cost of Illness 0.00291 Sjogren's Syndrome 0.00716 Risk Factors 0.00268 Vitiligo 0.00692 Great Britain 0.00268 Vasculitis 0.00503 CA-15-3 Antigen 0.00260 Antibodies, Antineutrophil Cytoplasmic 0.00472 Cost Control 0.00260 Antiphospholipid Syndrome 0.00464 Drug Industry 0.00252 Immunoglobulin G 0.00440 Cost Savings 0.00252 Genetic Predisposition to Disease 0.00393 Risk Assessment 0.00236 Polyendocrinopathies, Autoimmune 0.00385 Adult 0.00220 TOPIC 223 0.00139 TOPIC 224 0.00138 physic 0.05489 individu 0.19846 peak 0.04116 preval 0.13942 exercis 0.04000 popul 0.08577 min 0.03605 studi 0.06090 perform 0.03050 data 0.03220 rest 0.02358 common 0.02974 train 0.02055 high 0.02721 strength 0.02054 survei 0.02645 measur 0.01971 total 0.02034 studi 0.01859 epidemiolog 0.01482 improv 0.01839 frequent 0.01397 maxim 0.01776 gener 0.01396 load 0.01744 examin 0.01234 mean 0.01563 identifi 0.01179 fall 0.01558 frequenc 0.01141 reach 0.01525 defin 0.01127 capac 0.01519 collect 0.01041 time 0.01468 repres 0.00989 minut 0.01306 base 0.00984 intens 0.01286 higher 0.00975 Exercise 0.06994 Prevalence 0.27462 Humans 0.04663 Italy 0.02442 Adult 0.02386 Adult 0.02020 Oxygen Consumption 0.02205 Cross-Sectional Studies 0.01948 Exercise Test 0.01874 Middle Aged 0.01630 Physical Fitness 0.01701 Adolescent 0.00915 Sports 0.01457 Humans 0.00716 Physical Endurance 0.01244 Age Distribution 0.00437 Exertion 0.01079 Czech Republic 0.00422 Walking 0.01016 Sex Distribution 0.00422 Time Factors 0.00921 Aged 0.00366 Biomechanics 0.00819 Health Surveys 0.00350 Motor Activity 0.00725 Child 0.00286 Musculoskeletal Equilibrium 0.00614 Population Surveillance 0.00286 Running 0.00614 Infant, Newborn 0.00262 Heart Rate 0.00606 Risk Factors 0.00254 Analysis of Variance 0.00480 Cohort Studies 0.00231 Physical Conditioning, Animal 0.00457 Child, Preschool 0.00223 Accidental Falls 0.00449 Age Factors 0.00215 Aged 0.00433 Aged, 80 and over 0.00199 TOPIC 225 0.00138 TOPIC 226 0.00136 dai 0.25655 overexpress 0.16493 week 0.10157 her-2 0.05144 inject 0.04512 amplif 0.05138 follow 0.02318 her2 0.04625 time 0.02299 express 0.04584 period 0.02096 neu 0.04314 observ 0.01952 hgf 0.02845 decreas 0.01935 statu 0.02816 daili 0.01874 trastuzumab 0.01980 rabbit 0.01771 oncogen 0.01978 receiv 0.01755 human 0.01621 hour 0.01385 associ 0.01616 effect 0.01324 correl 0.01432 start 0.01181 met 0.01335 control 0.01154 tumor 0.01279 given 0.00975 observ 0.01175 salin 0.00952 ihc 0.01146 twice 0.00949 suggest 0.01137 treat 0.00917 determin 0.01096 signific 0.00901 fas 0.01065 Time Factors 0.12985 Receptor, erbB-2 0.19459 Rabbits 0.05197 Gene Amplification 0.06931 Animals 0.02081 Genes, erbB-2 0.05919 Dose-Response Relationship, Drug 0.00502 Hepatocyte Growth Factor 0.04272 Drug Therapy, Combination 0.00486 Immunohistochemistry 0.03927 Treatment Outcome 0.00446 Antibodies, Monoclonal 0.03100 Injections 0.00415 In Situ Hybridization, Fluorescence 0.01903 Drug Administration Schedule 0.00407 Proto-Oncogene Proteins c-met 0.01895 Injections, Subcutaneous 0.00407 Breast Neoplasms 0.01470 Disease Models, Animal 0.00391 Gene Expression Regulation, Neoplastic 0.01421 Injections, Intramuscular 0.00327 Up-Regulation 0.00803 Random Allocation 0.00303 Humans 0.00602 Humans 0.00271 Tumor Markers, Biological 0.00570 Adult 0.00247 Chromosomes, Human, Pair 17 0.00498 Recombinant Proteins 0.00247 DNA-Binding Proteins 0.00426 Animals, Newborn 0.00247 DNA Topoisomerases, Type II, Eukaryotic 0.00418 Analysis of Variance 0.00239 Adult 0.00385 Glucocorticoids 0.00231 Antigens, Neoplasm 0.00385 Age Factors 0.00223 Aged, 80 and over 0.00345 Drug Combinations 0.00215 Gene Dosage 0.00337 TOPIC 227 0.00136 TOPIC 228 0.00134 product 0.21541 activ 0.90345 synthesi 0.09781 inact 0.01373 enzym 0.04759 constitut 0.01152 synthas 0.04201 activat 0.00986 biosynthesi 0.04184 enzymat 0.00722 produc 0.02784 depend 0.00674 involv 0.02346 exhibit 0.00552 metabol 0.02193 abil 0.00535 accumul 0.02147 activiti 0.00338 pathwai 0.02039 modul 0.00257 reductas 0.01655 contrast 0.00244 synthes 0.01248 active 0.00194 intermedi 0.01208 indic 0.00180 synthetas 0.01166 strong 0.00142 step 0.01160 deactiv 0.00096 precursor 0.01091 conclud 0.00080 biosynthet 0.01060 strongest 0.00079 heme 0.01042 demonstr 0.00072 novo 0.01009 diminish 0.00060 coenzym 0.00779 vitro 0.00055 Alkyl and Aryl Transferases 0.02794 Enzyme Activation 0.07905 Gene Expression Regulation, Enzymologic 0.01397 Humans 0.01892 Streptomyces 0.01381 Animals 0.01163 Thymidylate Synthase 0.01308 Time Factors 0.01024 Humans 0.01268 Mice 0.00713 Farnesyltranstransferase 0.01074 Dose-Response Relationship, Drug 0.00639 Molecular Structure 0.00929 Recombinant Proteins 0.00573 Heme 0.00775 Cell Line 0.00549 Amino Acid Sequence 0.00678 Kinetics 0.00451 Acyltransferases 0.00638 Rats 0.00418 Terpenes 0.00557 Cells, Cultured 0.00393 Ubiquinone 0.00525 Signal Transduction 0.00344 Biotin 0.00501 Genes, Reporter 0.00319 Gene Expression Regulation, Bacterial 0.00476 Electrophoresis, Polyacrylamide Gel 0.00287 Polyketide Synthases 0.00476 Carrier Proteins 0.00270 Time Factors 0.00460 Enzyme Inhibitors 0.00270 Models, Chemical 0.00444 Transfection 0.00270 Carotenoids 0.00436 Mutation 0.00262 Enzymes 0.00388 Immunoblotting 0.00262 Molecular Sequence Data 0.00363 Gene Expression Regulation, Enzymologic 0.00262 TOPIC 229 0.00134 TOPIC 230 0.00133 inform 0.14877 lesion 0.17815 provid 0.05770 featur 0.08660 sourc 0.03307 patholog 0.03923 decis 0.03293 characterist 0.02832 avail 0.03209 histolog 0.02735 make 0.02779 atyp 0.02607 need 0.02508 find 0.02361 help 0.02014 dysplasia 0.02318 choic 0.01869 typic 0.01869 consid 0.01599 clinic 0.01869 current 0.01546 hyperplasia 0.01812 appropri 0.01537 benign 0.01712 knowledg 0.01493 histopatholog 0.01712 difficult 0.01422 entiti 0.01552 guid 0.01342 examin 0.01428 possibl 0.01307 common 0.01405 approach 0.01254 morpholog 0.01386 concern 0.01195 foci 0.01230 obtain 0.01133 includ 0.01123 discuss 0.00989 repres 0.01080 Humans 0.05654 Precancerous Conditions 0.07039 Decision Making 0.02092 Humans 0.04349 United States 0.00812 Diagnosis, Differential 0.03606 Informed Consent 0.00607 Middle Aged 0.02855 Choice Behavior 0.00566 Hyperplasia 0.02690 Patient Education 0.00542 Immunohistochemistry 0.02055 Decision Support Techniques 0.00418 Adult 0.01939 Aged 0.00361 Biopsy 0.00982 Patient Participation 0.00295 Adolescent 0.00957 Risk Assessment 0.00287 Cell Transformation, Neoplastic 0.00776 Animals 0.00279 Child 0.00652 Time Factors 0.00279 Aged 0.00652 Research Design 0.00279 Biopsy, Needle 0.00487 Internet 0.00279 Aged, 80 and over 0.00454 Genetic Screening 0.00263 Tumor Markers, Biological 0.00396 Data Collection 0.00263 Disease Progression 0.00396 Information Dissemination 0.00254 Osteochondrodysplasias 0.00330 Neoplasms 0.00246 Tomography, X-Ray Computed 0.00314 Family 0.00230 Skin Neoplasms 0.00297 Attitude to Health 0.00230 Prognosis 0.00281 TOPIC 231 0.00133 TOPIC 232 0.00132 predict 0.20986 sensit 0.23400 classif 0.05423 detect 0.23206 base 0.04942 specif 0.12114 set 0.04089 assai 0.08045 classifi 0.03502 test 0.03837 accuraci 0.02563 compar 0.02136 discrimin 0.02248 highli 0.02094 categori 0.02129 determin 0.01685 data 0.02014 limit 0.01609 select 0.01962 respect 0.01348 valu 0.01779 high 0.01160 accur 0.01658 method 0.01061 valid 0.01527 examin 0.01003 accord 0.01514 evalu 0.00931 featur 0.01474 rapid 0.00841 characterist 0.01387 valu 0.00658 combin 0.01351 tool 0.00541 analysi 0.01251 threshold 0.00532 best 0.01178 enzyme-link 0.00531 better 0.01145 immunosorb 0.00514 Predictive Value of Tests 0.12387 Sensitivity and Specificity 0.26289 ROC Curve 0.03239 Enzyme-Linked Immunosorbent Assay 0.02656 Sensitivity and Specificity 0.02900 Reproducibility of Results 0.01473 Reproducibility of Results 0.02884 Humans 0.00910 Humans 0.02661 Predictive Value of Tests 0.00530 Prognosis 0.00909 Animals 0.00405 Algorithms 0.00760 Time Factors 0.00381 Tumor Markers, Biological 0.00578 Polymerase Chain Reaction 0.00381 Artificial Intelligence 0.00454 Biosensing Techniques 0.00364 Diagnosis, Computer-Assisted 0.00454 Middle Aged 0.00314 Software 0.00446 ROC Curve 0.00248 Adult 0.00430 Immunoassay 0.00240 Computational Biology 0.00421 Biological Assay 0.00215 United States 0.00397 Reagent Kits, Diagnostic 0.00215 Discriminant Analysis 0.00388 Child, Preschool 0.00190 Aged, 80 and over 0.00372 Adult 0.00182 Sequence Analysis, Protein 0.00372 Child 0.00174 Adolescent 0.00322 Biological Markers 0.00174 Forecasting 0.00314 False Positive Reactions 0.00174 Data Interpretation, Statistical 0.00256 Aged 0.00165 TOPIC 233 0.00131 TOPIC 234 0.00130 possibl 0.05821 combin 0.31799 remain 0.05736 effect 0.10693 question 0.05670 treatment 0.04992 address 0.04008 cisplatin 0.04061 rais 0.03954 agent 0.03186 caus 0.02589 synergist 0.03184 issu 0.02251 enhanc 0.03156 despit 0.02066 addit 0.03125 fragil 0.01924 plu 0.02346 recent 0.01722 compar 0.01846 concern 0.01717 increas 0.01636 ataxia 0.01709 investig 0.01531 evid 0.01707 cytotox 0.01503 consid 0.01560 result 0.01475 expans 0.01482 observ 0.01448 exist 0.01447 platinum 0.01052 controversi 0.01373 simultan 0.01039 answer 0.01369 singl 0.01026 common 0.01294 treat 0.00988 clear 0.01266 follow 0.00978 Humans 0.04533 Cisplatin 0.13229 Fragile X Syndrome 0.03673 Drug Synergism 0.10706 Fragile X Mental Retardation Protein 0.03581 Antineoplastic Agents 0.03662 RNA-Binding Proteins 0.03422 Antineoplastic Combined Chemotherapy Protocols 0.02885 Nerve Tissue Proteins 0.03063 Drug Therapy, Combination 0.02860 Spinocerebellar Ataxias 0.02237 Organoplatinum Compounds 0.01535 Ataxia 0.01027 Combined Modality Therapy 0.01375 Trinucleotide Repeat Expansion 0.00851 Tumor Cells, Cultured 0.00532 Trinucleotide Repeats 0.00634 Drug Resistance, Neoplasm 0.00498 United States 0.00518 Dose-Response Relationship, Drug 0.00456 Animals 0.00509 Drug Screening Assays, Antitumor 0.00430 Friedreich Ataxia 0.00492 Cell Survival 0.00422 Cerebellar Ataxia 0.00442 Drug Combinations 0.00422 Mutation 0.00426 Humans 0.00354 Nuclear Proteins 0.00384 Drug Interactions 0.00337 DNA 0.00351 Apoptosis 0.00295 Machado-Joseph Disease 0.00351 Animals 0.00262 Adolescent 0.00267 Carboplatin 0.00228 Spinocerebellar Degenerations 0.00267 Time Factors 0.00219 Tremor 0.00259 Mice 0.00194 TOPIC 235 0.00128 TOPIC 236 0.00128 new 0.36603 role 0.44265 origin 0.08729 plai 0.23685 describ 0.03133 suggest 0.04428 base 0.02339 critic 0.03527 possibl 0.02212 kei 0.02832 establish 0.02004 develop 0.02288 newli 0.01961 crucial 0.01903 provid 0.01925 pathogenesi 0.01733 propos 0.01910 essenti 0.01565 call 0.01907 major 0.01169 introduct 0.01630 pivot 0.01169 exist 0.01482 implic 0.01100 introduc 0.01418 involv 0.01077 discov 0.01329 central 0.00994 addit 0.01180 process 0.00746 far 0.01177 thought 0.00744 recent 0.01130 furthermor 0.00699 world 0.01123 evid 0.00673 zealand 0.01095 mainten 0.00508 insight 0.01092 believ 0.00417 Humans 0.05359 Animals 0.04749 Animals 0.02765 Humans 0.04544 New Zealand 0.01075 Mice 0.01037 United States 0.00811 Mutation 0.00574 Chlamydomonas reinhardtii 0.00666 Neoplasms 0.00549 Mutation 0.00597 DNA-Binding Proteins 0.00480 History, 20th Century 0.00393 Membrane Proteins 0.00472 Child 0.00307 Signal Transduction 0.00429 Signal Transduction 0.00299 Nuclear Proteins 0.00411 Terminology 0.00282 Time Factors 0.00411 Neoplasms 0.00265 Amino Acid Sequence 0.00377 Models, Biological 0.00239 Phenotype 0.00360 New York 0.00239 Apoptosis 0.00351 Molecular Sequence Data 0.00230 Transcription Factors 0.00351 Child, Preschool 0.00230 Down-Regulation 0.00317 Time Factors 0.00213 Models, Biological 0.00317 Base Sequence 0.00205 Gene Expression Regulation 0.00317 Mice 0.00205 Carrier Proteins 0.00317 Adult 0.00205 Reverse Transcriptase Polymerase Chain Reaction 0.00309 Gene Expression Regulation 0.00196 Up-Regulation 0.00291 TOPIC 237 0.00127 TOPIC 238 0.00127 size 0.20273 time 0.30690 area 0.07598 period 0.08439 small 0.06071 point 0.08205 larg 0.05178 cours 0.02738 space 0.04480 durat 0.02665 larger 0.04138 chang 0.02458 smaller 0.03447 longer 0.02212 differ 0.02484 end 0.02203 shape 0.01895 occur 0.01903 diamet 0.01755 continu 0.01674 number 0.01719 follow 0.01513 compar 0.01377 start 0.01354 rel 0.01116 tempor 0.01347 measur 0.01104 real 0.01322 greater 0.00938 shorter 0.01184 averag 0.00919 reach 0.01158 flight 0.00882 long 0.01065 mar 0.00845 prolong 0.01059 experi 0.00842 appear 0.00973 rang 0.00816 emerg 0.00972 Space Flight 0.07882 Time Factors 0.20087 Spacecraft 0.03392 Humans 0.02277 Weightlessness 0.03046 Animals 0.00658 Extraterrestrial Environment 0.02864 United States 0.00623 Astronauts 0.02777 Kinetics 0.00234 Mars 0.01436 Time 0.00225 Humans 0.01159 Adult 0.00216 Aerospace Medicine 0.01125 Aging 0.00216 Body Size 0.01099 Great Britain 0.00216 United States National Aeronautics and Space Administration 0.01021 Longitudinal Studies 0.00216 Cosmic Radiation 0.00666 Middle Aged 0.00208 Time Factors 0.00597 Models, Biological 0.00199 Animals 0.00510 Sensitivity and Specificity 0.00199 Solar Activity 0.00476 Analysis of Variance 0.00199 United States 0.00441 Waiting Lists 0.00165 Moon 0.00363 Adolescent 0.00147 Adult 0.00311 Treatment Outcome 0.00147 Weightlessness Simulation 0.00303 Risk Factors 0.00147 Saturn 0.00251 Clinical Trials 0.00147 Earth (Planet) 0.00234 Mice 0.00139 TOPIC 239 0.00126 TOPIC 240 0.00125 injuri 0.11974 multipl 0.31407 follow 0.06991 singl 0.13671 delai 0.06754 myeloma 0.04891 recoveri 0.05089 includ 0.04462 later 0.03942 doubl 0.02673 caus 0.02590 simultan 0.02110 regener 0.02560 studi 0.02090 hour 0.02113 combin 0.02044 trauma 0.02033 demonstr 0.01916 acut 0.02004 indic 0.01589 examin 0.01861 independ 0.01322 damag 0.01783 provid 0.01186 recov 0.01571 sclerosi 0.01166 sod1 0.01417 highli 0.01070 als 0.01387 thalidomid 0.01030 immedi 0.01152 bortezomib 0.00982 sclerosi 0.01141 result 0.00820 initi 0.01119 number 0.00797 prolong 0.01112 despit 0.00767 depriv 0.01091 occur 0.00707 Amyotrophic Lateral Sclerosis 0.05244 Multiple Myeloma 0.18549 Superoxide Dismutase 0.02770 Multiple Sclerosis 0.04260 Time Factors 0.02448 Thalidomide 0.02819 Wounds and Injuries 0.02108 Boronic Acids 0.02652 Humans 0.02004 Pyrazines 0.02617 Brain Injuries 0.01594 Humans 0.02503 Regeneration 0.01281 Dexamethasone 0.00843 Burns 0.00967 Protease Inhibitors 0.00703 Recovery of Function 0.00845 Plasma Cells 0.00606 Reperfusion Injury 0.00836 Antineoplastic Agents 0.00492 Animals 0.00636 Animals 0.00263 Craniocerebral Trauma 0.00618 Time Factors 0.00237 Motor Neurons 0.00566 Antineoplastic Combined Chemotherapy Protocols 0.00237 Acute Disease 0.00453 Recurrence 0.00228 Disease Models, Animal 0.00409 Glycoproteins 0.00220 Spinal Cord Injuries 0.00383 Follow-Up Studies 0.00211 Natural Disasters 0.00366 Membrane Glycoproteins 0.00211 Wounds, Nonpenetrating 0.00366 Research Design 0.00211 Accidents, Traffic 0.00331 Stem Cell Transplantation 0.00202 Eye Injuries 0.00322 Paraproteinemias 0.00202 TOPIC 241 0.00124 TOPIC 242 0.00124 oral 0.12829 region 0.36701 studi 0.06574 segment 0.06614 brca1 0.05021 locat 0.06422 examin 0.02878 code 0.05379 brca2 0.02349 sequenc 0.04163 periodont 0.02228 contain 0.02714 clinic 0.02144 proxim 0.02436 determin 0.01887 site 0.01962 follow 0.01744 identifi 0.01680 includ 0.01631 distal 0.01629 develop 0.01562 overlap 0.01300 prophylact 0.01478 flank 0.01298 signific 0.01465 map 0.01145 nat2 0.01409 entir 0.01045 plaqu 0.01371 approxim 0.01014 gingiv 0.01209 end 0.00903 caviti 0.01185 upstream 0.00889 nat 0.01178 adjac 0.00852 indic 0.01150 boundari 0.00744 observ 0.01149 portion 0.00735 Mouth Neoplasms 0.07000 Molecular Sequence Data 0.03102 Genes, BRCA1 0.05247 Base Sequence 0.03058 Genes, BRCA2 0.03355 Humans 0.01025 Mouth Mucosa 0.02756 Sequence Analysis, DNA 0.00963 Arylamine N-Acetyltransferase 0.02738 Forms and Records Control 0.00795 BRCA1 Protein 0.02377 Animals 0.00742 Periodontitis 0.01963 Sequence Alignment 0.00566 Humans 0.01497 Chromosome Mapping 0.00521 Saliva 0.01488 DNA, Intergenic 0.00504 Dental Caries 0.01259 DNA Primers 0.00460 Dental Plaque 0.01224 Polymerase Chain Reaction 0.00442 BRCA2 Protein 0.01197 Sequence Homology, Nucleic Acid 0.00442 Gingiva 0.01057 United States 0.00389 Administration, Oral 0.00766 Cloning, Molecular 0.00380 Periodontal Diseases 0.00678 Mice 0.00345 Acetylation 0.00669 Sequence Deletion 0.00345 Areca 0.00484 Current Procedural Terminology 0.00345 Breast Neoplasms 0.00431 Open Reading Frames 0.00336 Toothbrushing 0.00431 Models, Genetic 0.00318 Periodontal Index 0.00396 3' Untranslated Regions 0.00300 TOPIC 243 0.00121 TOPIC 244 0.00120 variant 0.26906 format 0.24921 hypertens 0.07767 form 0.03431 common 0.05846 chondrocyt 0.02927 associ 0.05199 cartilag 0.02920 studi 0.04755 suggest 0.02883 suggest 0.03432 studi 0.02686 differ 0.02389 sulfat 0.02354 contribut 0.01709 demonstr 0.01972 determin 0.01636 indic 0.01862 essenti 0.01398 result 0.01721 rare 0.01388 involv 0.01677 addit 0.01370 zone 0.01665 observ 0.01364 determin 0.01493 investig 0.01223 sox9 0.01437 carri 0.01128 lead 0.01316 relat 0.01051 develop 0.01312 similar 0.00994 plate 0.01160 examin 0.00990 reveal 0.01007 evid 0.00891 proteoglycan 0.00972 possibl 0.00859 addit 0.00962 Hypertension 0.16960 Chondrocytes 0.07567 Variation (Genetics) 0.11639 Cartilage, Articular 0.02998 Blood Pressure 0.02556 High Mobility Group Proteins 0.02486 Rats, Inbred SHR 0.01459 Cartilage 0.02376 Antihypertensive Agents 0.00943 Collagen Type II 0.01810 Receptors, Adrenergic, beta-2 0.00743 Proteoglycans 0.01746 Renin 0.00635 Glycosaminoglycans 0.01618 Humans 0.00562 Animals 0.01545 Renin-Angiotensin System 0.00471 Chondrogenesis 0.01334 Rats, Inbred WKY 0.00462 Osteoarthritis 0.01152 Protein-Serine-Threonine Kinases 0.00435 Heparitin Sulfate 0.00987 Genetic Predisposition to Disease 0.00399 Extracellular Matrix Proteins 0.00658 Aldosterone 0.00381 Growth Plate 0.00649 Polymorphism, Genetic 0.00354 Extracellular Matrix 0.00548 Cardiovascular Diseases 0.00344 Hyaluronic Acid 0.00475 Mutation, Missense 0.00290 Lectins, C-Type 0.00448 Animals 0.00281 Humans 0.00430 Genotype 0.00272 Glycoproteins 0.00402 Heart Rate 0.00272 Osteochondrodysplasias 0.00393 Middle Aged 0.00254 Cells, Cultured 0.00356 TOPIC 245 0.00120 TOPIC 246 0.00119 defect 0.13657 group 0.64105 sever 0.11769 differ 0.05453 abnorm 0.11296 control 0.04281 normal 0.09820 signific 0.03266 caus 0.07000 compar 0.03063 impair 0.06616 divid 0.02405 mild 0.03246 respect 0.02289 dysfunct 0.03089 accord 0.01379 affect 0.02388 higher 0.01326 associ 0.02150 statist 0.01261 defici 0.01941 methods 0.01171 moder 0.01778 subgroup 0.01076 dysplasia 0.01504 mean 0.01015 lead 0.01287 aim 0.00840 result 0.01250 total 0.00791 failur 0.01130 randomli 0.00658 excess 0.01119 comparison 0.00605 includ 0.00850 lower 0.00496 abnormal 0.00774 compris 0.00435 disturb 0.00763 classifi 0.00410 Humans 0.04647 Analysis of Variance 0.01729 Severity of Illness Index 0.02287 Adult 0.01526 Infant 0.00796 Case-Control Studies 0.01342 Child 0.00677 Humans 0.01131 Neural Tube Defects 0.00650 Statistics, Nonparametric 0.00947 Osteochondrodysplasias 0.00650 Adolescent 0.00892 Adolescent 0.00567 Middle Aged 0.00837 Infant, Newborn 0.00503 Random Allocation 0.00561 Mutation 0.00485 Prospective Studies 0.00405 Adult 0.00439 Retrospective Studies 0.00368 Middle Aged 0.00393 Age Factors 0.00359 Pregnancy 0.00393 Child 0.00340 Ectodermal Dysplasia 0.00375 Chi-Square Distribution 0.00340 Spinal Dysraphism 0.00348 Aged 0.00331 Phenotype 0.00338 Time Factors 0.00303 Animals 0.00329 Child, Preschool 0.00276 Folic Acid 0.00302 Animals 0.00257 Aged 0.00284 Reference Values 0.00248 Child, Preschool 0.00247 Treatment Outcome 0.00248 Time Factors 0.00238 Severity of Illness Index 0.00248 TOPIC 247 0.00119 TOPIC 248 0.00118 local 0.28716 secret 0.11566 junction 0.06875 gland 0.07734 gap 0.04353 mammari 0.07576 barrier 0.02761 spontan 0.05708 suggest 0.01887 increas 0.02950 function 0.01886 camp 0.02809 connexin 0.01851 cyclic 0.02664 coupl 0.01824 salivari 0.02519 subcellular 0.01708 suggest 0.02321 commun 0.01691 develop 0.02112 demonstr 0.01673 secretori 0.01757 indic 0.01671 studi 0.01718 tight 0.01661 indic 0.01602 distribut 0.01283 demonstr 0.01542 cx43 0.01230 pka 0.01542 form 0.01086 creb 0.01485 intercellular 0.01042 role 0.01326 locat 0.01003 observ 0.00964 disrupt 0.00974 cyclas 0.00943 consist 0.00938 acc 0.00903 Connexins 0.07092 Cyclic AMP 0.08456 Gap Junctions 0.06047 Mammary Glands, Animal 0.06273 Connexin 43 0.04457 Cyclic AMP-Dependent Protein Kinases 0.03636 Cell Communication 0.03597 Cyclic AMP Response Element-Binding Protein 0.02100 Membrane Proteins 0.03070 Mammary Neoplasms, Experimental 0.01767 Tight Junctions 0.02330 Salivary Gland Neoplasms 0.01591 Animals 0.00934 Salivary Glands 0.01360 Phosphoproteins 0.00934 Mammary Neoplasms, Animal 0.01082 Adherens Junctions 0.00915 Adenylate Cyclase 0.01045 Microscopy, Fluorescence 0.00869 Lactation 0.00759 Humans 0.00786 Forskolin 0.00731 Microscopy, Confocal 0.00518 Animals 0.00435 Mice 0.00435 Parotid Gland 0.00435 Immunohistochemistry 0.00425 Cyclic GMP 0.00416 Intercellular Junctions 0.00425 Guanylate Cyclase 0.00361 Subcellular Fractions 0.00416 Isoproterenol 0.00352 Cytoskeletal Proteins 0.00388 Immunohistochemistry 0.00342 Cell Membrane 0.00342 Humans 0.00333 Blotting, Western 0.00333 Pregnancy 0.00333 Protein Transport 0.00333 Mammary Glands, Human 0.00324 TOPIC 249 0.00117 TOPIC 250 0.00115 earli 0.25235 identifi 0.29929 develop 0.24004 novel 0.15800 stage 0.18004 identif 0.11941 late 0.06892 character 0.04221 development 0.04331 candid 0.04001 onset 0.02657 known 0.03386 progress 0.01978 approach 0.03016 later 0.01787 potenti 0.02647 earlier 0.01269 analysi 0.02254 initi 0.01198 search 0.01789 advanc 0.00955 new 0.01747 event 0.00916 includ 0.01439 subsequ 0.00802 screen 0.01268 life 0.00682 repres 0.01146 appear 0.00678 unknown 0.00967 occur 0.00637 confirm 0.00964 delai 0.00614 discov 0.00834 earliest 0.00527 put 0.00748 matur 0.00506 allow 0.00675 begin 0.00479 uniqu 0.00585 Gene Expression Regulation, Developmental 0.04382 Molecular Sequence Data 0.03030 Time Factors 0.03728 Humans 0.01376 Animals 0.00972 Amino Acid Sequence 0.01109 Humans 0.00916 Base Sequence 0.01090 Early Diagnosis 0.00822 Animals 0.00745 Neoplasm Staging 0.00748 Mice 0.00745 Age of Onset 0.00589 Computational Biology 0.00573 Disease Progression 0.00514 Sequence Analysis, DNA 0.00545 Mice 0.00411 Sequence Alignment 0.00526 Age Factors 0.00374 Proteins 0.00459 Pregnancy 0.00336 DNA Primers 0.00411 Polymerase Chain Reaction 0.00308 DNA, Complementary 0.00411 Aged 0.00299 Gene Expression Profiling 0.00382 Developmental Disabilities 0.00299 Mutation 0.00363 Child 0.00280 Reverse Transcriptase Polymerase Chain Reaction 0.00354 Cell Differentiation 0.00271 Neoplasm Proteins 0.00344 Infant 0.00252 Cloning, Molecular 0.00335 Models, Biological 0.00252 Chromosome Mapping 0.00315 Molecular Sequence Data 0.00234 Phylogeny 0.00315 Severity of Illness Index 0.00224 Phenotype 0.00287 TOPIC 251 0.00114 TOPIC 252 0.00114 increas 0.46704 induc 0.30968 decreas 0.19887 induct 0.15853 level 0.06912 activ 0.02450 reduc 0.02502 manner 0.02247 compar 0.02433 suggest 0.02079 observ 0.01735 increas 0.01956 result 0.01696 mechan 0.01897 chang 0.01234 treatment 0.01871 5-fold 0.00909 respons 0.01823 2-fold 0.00795 indic 0.01758 reduct 0.00698 result 0.01731 markedli 0.00655 effect 0.01717 accompani 0.00646 depend 0.01648 3-fold 0.00646 mediat 0.01515 mark 0.00613 demonstr 0.01279 parallel 0.00551 furthermor 0.01240 4-fold 0.00547 induction 0.01180 dramat 0.00438 cell 0.01143 6-fold 0.00416 follow 0.01007 concomit 0.00407 addit 0.00965 Time Factors 0.01686 Dose-Response Relationship, Drug 0.03068 Animals 0.00665 Time Factors 0.01804 Humans 0.00655 Cells, Cultured 0.01264 Up-Regulation 0.00540 Enzyme Induction 0.00926 Cells, Cultured 0.00511 Animals 0.00762 Aging 0.00501 Humans 0.00752 Middle Aged 0.00424 Mice 0.00656 Dose-Response Relationship, Drug 0.00414 Cell Line 0.00521 Gene Expression 0.00376 Cell Line, Tumor 0.00511 Gene Expression Regulation 0.00308 DNA-Binding Proteins 0.00482 Reverse Transcriptase Polymerase Chain Reaction 0.00289 Blotting, Western 0.00444 Blotting, Western 0.00289 Fenretinide 0.00444 Adult 0.00270 Proteins 0.00434 Down-Regulation 0.00260 Up-Regulation 0.00386 RNA, Messenger 0.00260 Flow Cytometry 0.00367 Membrane Glycoproteins 0.00260 Enzyme Inhibitors 0.00367 Immunohistochemistry 0.00251 Apoptosis 0.00338 Blotting, Northern 0.00251 Reverse Transcriptase Polymerase Chain Reaction 0.00318 Gene Expression Regulation, Enzymologic 0.00241 Antineoplastic Agents 0.00318 Recombinant Proteins 0.00231 RNA, Messenger 0.00299 TOPIC 253 0.00113 TOPIC 254 0.00113 mechan 0.29208 stimul 0.18055 involv 0.06566 releas 0.08990 underli 0.06358 activ 0.08603 molecular 0.06125 increas 0.04645 remain 0.05615 effect 0.04261 understood 0.04800 stat3 0.03411 action 0.04030 mediat 0.02879 poorli 0.03606 demonstr 0.02798 elucid 0.02638 act 0.02595 unknown 0.02586 induc 0.02180 known 0.02071 suggest 0.02036 process 0.01756 mechan 0.01796 unclear 0.01679 block 0.01501 contribut 0.01622 depend 0.01333 fulli 0.01292 lead 0.01311 understand 0.01168 respons 0.01276 precis 0.01141 contrast 0.01218 implic 0.01134 basal 0.01152 lead 0.00967 constitut 0.01150 phenomenon 0.00851 data 0.01126 Animals 0.04206 STAT3 Transcription Factor 0.07016 Humans 0.01344 Trans-Activators 0.01616 Models, Biological 0.00996 Time Factors 0.00948 Signal Transduction 0.00648 Animals 0.00890 Time Factors 0.00551 Humans 0.00677 Mice 0.00474 Cells, Cultured 0.00542 DNA-Binding Proteins 0.00425 Mice 0.00532 Mutation 0.00406 Dose-Response Relationship, Drug 0.00513 Rats 0.00367 Rats 0.00513 Gene Expression 0.00329 Signal Transduction 0.00474 Membrane Glycoproteins 0.00329 Enzyme Activation 0.00397 Transcription Factors 0.00309 Kinetics 0.00397 Trans-Activators 0.00309 Cell Line 0.00368 Nuclear Proteins 0.00300 DNA-Binding Proteins 0.00358 Blotting, Western 0.00300 Protein Binding 0.00329 Gene Expression Regulation 0.00290 Phosphorylation 0.00300 Membrane Proteins 0.00280 Models, Biological 0.00300 Cells, Cultured 0.00271 Proteins 0.00290 Dose-Response Relationship, Drug 0.00271 Recombinant Proteins 0.00281 Protein Structure, Tertiary 0.00271 Peptides 0.00271 TOPIC 255 0.00112 TOPIC 256 0.00111 core 0.07045 tissu 0.45843 approxim 0.04664 normal 0.26199 glycosyl 0.02875 adjac 0.02184 glycoprotein 0.02773 detect 0.02172 character 0.02342 compar 0.01565 nf1 0.01966 stain 0.01132 structur 0.01888 section 0.01059 indic 0.01863 specimen 0.01003 lectin 0.01663 immunohistochemistri 0.00992 reveal 0.01660 patholog 0.00979 suggest 0.01654 surround 0.00833 addit 0.01630 microdissect 0.00784 studi 0.01557 immunohistochem 0.00696 demonstr 0.01545 correspond 0.00683 known 0.01452 neoplast 0.00661 report 0.01363 analyz 0.00579 carbohydr 0.01326 sampl 0.00540 similar 0.01309 match 0.00511 major 0.01293 examin 0.00488 neurofibromatosi 0.01269 paraffin-embed 0.00442 Glycosylation 0.09448 Immunohistochemistry 0.07565 Neurofibromatosis 1 0.04170 Tissue Distribution 0.02776 Glycoproteins 0.02914 Middle Aged 0.02766 Polysaccharides 0.02433 Aged 0.02013 Oligosaccharides 0.02109 Organ Specificity 0.01289 Carbohydrate Sequence 0.01118 Humans 0.01150 Neurilemmoma 0.00893 Aged, 80 and over 0.01091 Mannose-Binding Lectin 0.00893 Adult 0.01011 Galactose 0.00883 Paraffin Embedding 0.00991 Humans 0.00706 Microdissection 0.00833 CA-15-3 Antigen 0.00638 Case-Control Studies 0.00506 Galactosemias 0.00628 Immunoenzyme Techniques 0.00486 Glycosyltransferases 0.00589 Lasers 0.00466 Lectins 0.00569 Animals 0.00446 Neurofibromatosis 2 0.00461 RNA, Messenger 0.00416 Mannose 0.00451 Polymerase Chain Reaction 0.00367 Galactosyltransferases 0.00432 Microscopy, Fluorescence 0.00357 Molecular Chaperones 0.00412 Neoplasm Proteins 0.00347 N-Acetylglucosaminyltransferases 0.00412 Adenocarcinoma 0.00347 Carbohydrate Conformation 0.00402 Formaldehyde 0.00347 TOPIC 257 0.00109 TOPIC 258 0.00109 reaction 0.22175 concentr 0.26817 chain 0.21396 plasma 0.14180 polymeras 0.13194 microg 0.05873 revers 0.08448 level 0.04201 detect 0.03756 measur 0.03204 pcr 0.02656 higher 0.03092 heavi 0.02374 determin 0.02823 analysi 0.02359 increas 0.02777 determin 0.02249 free 0.02670 rt-pcr 0.01932 total 0.02246 confirm 0.01450 lower 0.02162 analyz 0.01361 micromol 0.02162 real-tim 0.01301 respect 0.02141 transcription-polymeras 0.01256 rang 0.02131 presenc 0.01130 low 0.01860 transcriptase-polymeras 0.00973 valu 0.01618 perform 0.00953 nmol 0.01198 methods 0.00829 high 0.01131 quantit 0.00802 mean 0.01046 transcriptas 0.00702 highest 0.00927 Polymerase Chain Reaction 0.14412 Dose-Response Relationship, Drug 0.02295 Reverse Transcriptase Polymerase Chain Reaction 0.09330 Time Factors 0.00876 DNA Primers 0.01147 Chromatography, High Pressure Liquid 0.00856 Humans 0.01017 Reference Values 0.00654 Animals 0.00493 Biological Markers 0.00654 Sensitivity and Specificity 0.00483 Adult 0.00644 Base Sequence 0.00453 Humans 0.00634 RNA, Messenger 0.00352 Middle Aged 0.00544 Aged 0.00322 Tissue Distribution 0.00403 Molecular Sequence Data 0.00282 Kinetics 0.00393 Adult 0.00272 Enzyme-Linked Immunosorbent Assay 0.00393 DNA, Neoplasm 0.00262 Mercury 0.00362 Middle Aged 0.00252 Water Pollutants, Chemical 0.00342 Time Factors 0.00252 Animals 0.00332 Immunohistochemistry 0.00211 Plasma 0.00312 Mice 0.00201 Hydrogen-Ion Concentration 0.00302 RNA 0.00191 Analysis of Variance 0.00302 Blotting, Southern 0.00191 Osmolar Concentration 0.00282 DNA-Binding Proteins 0.00171 Aged 0.00272 Mutation 0.00171 Case-Control Studies 0.00262 TOPIC 259 0.00107 TOPIC 260 0.00107 long 0.07218 switch 0.05109 life 0.07057 somat 0.04849 short 0.06653 exclus 0.02875 term 0.04585 suggest 0.02619 restrict 0.04249 aid 0.02525 limit 0.03930 occur 0.02501 extens 0.03792 specif 0.02265 extend 0.03389 requir 0.02135 span 0.02297 indic 0.02031 expect 0.02074 edit 0.01915 defin 0.01972 dual 0.01566 experi 0.01964 gener 0.01492 point 0.01858 appear 0.01472 gener 0.01527 contrast 0.01443 possibl 0.01522 deaminas 0.01439 opn 0.01429 drive 0.01386 extrem 0.01408 remain 0.01339 live 0.01367 lack 0.01239 appear 0.01328 like 0.01215 allow 0.01297 hypermut 0.01162 Longevity 0.08340 Cytidine Deaminase 0.05150 Aging 0.02398 Somatic Hypermutation, Immunoglobulin 0.02868 Humans 0.01660 RNA Editing 0.02508 Sialoglycoproteins 0.01660 Immunoglobulin Class Switching 0.02220 Animals 0.00707 B-Lymphocytes 0.02118 Caloric Restriction 0.00635 Cytosine Deaminase 0.02066 United States 0.00379 Adenosine Deaminase 0.01501 Life Expectancy 0.00338 Nucleoside Deaminases 0.01367 Age Factors 0.00287 Humans 0.01069 Time Factors 0.00277 Animals 0.00966 Middle Aged 0.00266 Repressor Proteins 0.00565 Quality of Life 0.00246 Proteins 0.00463 Evolution 0.00225 Mice 0.00411 History, 20th Century 0.00225 Mutation 0.00401 Polymorphism, Genetic 0.00205 RNA, Messenger 0.00360 Models, Biological 0.00195 Gene Expression Regulation 0.00360 Treatment Outcome 0.00195 Adenosine 0.00329 History, Ancient 0.00195 Genes, Immunoglobulin 0.00319 Attitude to Death 0.00195 Gene Products, vif 0.00308 Mice 0.00184 Molecular Sequence Data 0.00278 TOPIC 261 0.00105 TOPIC 262 0.00105 test 0.43370 sampl 0.39468 signific 0.07172 collect 0.07193 statist 0.06076 detect 0.05654 differ 0.05181 specimen 0.04069 evalu 0.02921 analysi 0.03848 perform 0.02806 analyz 0.02657 hypothesi 0.02680 method 0.02354 studi 0.02433 determin 0.02246 compar 0.01694 mix 0.02173 analysi 0.01599 test 0.02020 comparison 0.01338 total 0.01895 exact 0.01179 perform 0.01521 posit 0.01081 taken 0.01027 fisher 0.00865 analys 0.00969 standard 0.00755 extract 0.00963 assess 0.00735 forens 0.00865 chi 0.00716 limit 0.00709 hypothes 0.00704 studi 0.00672 consid 0.00699 separ 0.00595 anova 0.00695 captur 0.00557 Humans 0.02471 Humans 0.02254 Predictive Value of Tests 0.01241 Forensic Medicine 0.02056 Analysis of Variance 0.01084 Specimen Handling 0.01962 Genetic Screening 0.01053 DNA Fingerprinting 0.01451 Reference Values 0.00834 Polymerase Chain Reaction 0.01242 Reproducibility of Results 0.00751 Sensitivity and Specificity 0.01138 Statistics, Nonparametric 0.00719 Reproducibility of Results 0.00605 Sensitivity and Specificity 0.00615 Middle Aged 0.00532 Data Interpretation, Statistical 0.00573 Feces 0.00480 Adult 0.00563 Aged 0.00449 Biological Markers 0.00521 Reference Values 0.00417 Aged 0.00480 Time Factors 0.00397 Adolescent 0.00417 Tandem Repeat Sequences 0.00376 Research Design 0.00344 Adult 0.00365 Specimen Handling 0.00344 DNA 0.00344 Middle Aged 0.00334 Sequence Analysis, DNA 0.00292 Statistics 0.00302 Cryopreservation 0.00292 Models, Genetic 0.00292 Aged, 80 and over 0.00282 Animals 0.00271 Adolescent 0.00271 Child 0.00271 Child, Preschool 0.00271 TOPIC 263 0.00104 TOPIC 264 0.00103 effect 0.59584 function 0.67683 affect 0.05825 structur 0.04003 signific 0.03485 biolog 0.02065 reduc 0.03061 known 0.01489 increas 0.02084 physiolog 0.01481 examin 0.01999 unknown 0.01287 investig 0.01843 character 0.01260 exert 0.01841 essenti 0.01229 benefici 0.01374 impair 0.01216 studi 0.01225 role 0.01063 reduct 0.01124 relev 0.00871 advers 0.01047 consequ 0.00860 addit 0.01008 redund 0.00734 potenti 0.00996 aspect 0.00713 observ 0.00895 serv 0.00680 decreas 0.00741 elucid 0.00675 influenc 0.00727 identifi 0.00606 protect 0.00675 kei 0.00593 deleteri 0.00585 includ 0.00521 caus 0.00562 understand 0.00496 Time Factors 0.01209 Animals 0.01494 Animals 0.01167 Humans 0.01451 Humans 0.01156 Protein Structure, Tertiary 0.00540 Dose-Response Relationship, Drug 0.00683 Mutation 0.00509 Analysis of Variance 0.00536 Structure-Activity Relationship 0.00466 Rats 0.00294 Mice 0.00445 Drug Combinations 0.00252 Models, Biological 0.00445 Mutation 0.00242 Gene Expression Regulation 0.00413 Drug Interactions 0.00221 Membrane Proteins 0.00392 Mice 0.00210 Signal Transduction 0.00350 DNA 0.00210 Phenotype 0.00339 Cell Proliferation 0.00210 Amino Acid Sequence 0.00307 Cell Line, Tumor 0.00200 Cell Division 0.00307 Adolescent 0.00200 Protein Binding 0.00286 DNA-Binding Proteins 0.00200 Time Factors 0.00275 RNA, Messenger 0.00200 Binding Sites 0.00265 Neoplasms 0.00200 Transcription, Genetic 0.00265 DNA Primers 0.00189 Cloning, Molecular 0.00265 Aging 0.00189 Gene Expression 0.00244 Disease Models, Animal 0.00189 Molecular Sequence Data 0.00233 TOPIC 265 0.00102 TOPIC 266 0.00102 suppress 0.10434 control 0.56959 loss 0.07432 compar 0.08874 inactiv 0.06311 studi 0.04645 partial 0.05925 ace 0.02462 restor 0.04116 differ 0.02294 disrupt 0.03988 signific 0.02129 function 0.03697 angiotensin 0.01694 reduc 0.03610 match 0.01378 result 0.03542 enzym 0.01184 lead 0.03218 ang 0.01059 caus 0.03180 investig 0.00994 suggest 0.02694 higher 0.00924 complet 0.02347 agt 0.00877 suppressor 0.01890 age-match 0.00867 mechan 0.01714 ras 0.00790 demonstr 0.01592 aim 0.00693 contribut 0.01256 determin 0.00689 affect 0.01133 age- 0.00605 indic 0.01120 convert 0.00590 compens 0.01092 angiotensin-convert 0.00558 Animals 0.01787 Peptidyl-Dipeptidase A 0.06729 Nitrosamines 0.00770 Case-Control Studies 0.02821 Humans 0.00717 Receptor, Angiotensin, Type 1 0.02261 Gene Deletion 0.00653 Angiotensin II 0.02164 Gene Silencing 0.00653 Angiotensin-Converting Enzyme Inhibitors 0.01981 Mice 0.00610 Renin-Angiotensin System 0.01615 Down-Regulation 0.00503 Angiotensinogen 0.01066 Cell Line 0.00503 Angiotensin II Type 1 Receptor Blockers 0.01001 Mutation 0.00492 Humans 0.00528 Dosage Compensation, Genetic 0.00460 Animals 0.00517 Repressor Proteins 0.00385 Middle Aged 0.00355 Tumor Suppressor Proteins 0.00374 Hypertension 0.00269 Mice, Knockout 0.00353 Adult 0.00258 Trans-Activators 0.00353 Reference Values 0.00258 Cricetinae 0.00342 Time Factors 0.00215 Cells, Cultured 0.00310 Proteins 0.00205 Time Factors 0.00310 Polymerase Chain Reaction 0.00205 Base Sequence 0.00300 Gene Deletion 0.00183 Proteins 0.00300 Antihypertensive Agents 0.00183 DNA Primers 0.00289 Aged 0.00172 TOPIC 267 0.00100 TOPIC 268 0.00099 pattern 0.26030 relat 0.21974 cluster 0.14106 relationship 0.13352 similar 0.07323 close 0.07020 differ 0.05383 studi 0.05537 distinct 0.04832 japanes 0.04608 analysi 0.03056 correl 0.03849 consist 0.02095 examin 0.03262 observ 0.01891 investig 0.02893 analyz 0.01810 indic 0.02652 distribut 0.01757 suggest 0.02562 suggest 0.01466 japan 0.02429 profil 0.01395 possibl 0.02050 share 0.01255 probabl 0.01761 origin 0.01154 analyz 0.01612 displai 0.01151 includ 0.01534 spatial 0.01148 analys 0.01500 uniqu 0.01082 clarifi 0.01402 correspond 0.01068 order 0.01331 repres 0.00989 determin 0.01308 defin 0.00898 invers 0.01190 Cluster Analysis 0.07732 Japan 0.21065 Multigene Family 0.04119 Humans 0.00795 Animals 0.00615 Asian Continental Ancestry Group 0.00409 Humans 0.00593 Aged 0.00353 Sequence Analysis, DNA 0.00461 Animals 0.00320 Time Factors 0.00395 Adult 0.00320 Gene Expression Profiling 0.00329 Membrane Proteins 0.00254 Variation (Genetics) 0.00329 Adolescent 0.00243 Models, Genetic 0.00297 Child, Preschool 0.00232 Sequence Alignment 0.00275 DNA Mutational Analysis 0.00232 Models, Biological 0.00264 Regression Analysis 0.00210 Phylogeny 0.00264 DNA Primers 0.00199 Transcription Factors 0.00231 Genotype 0.00199 Oligonucleotide Array Sequence Analysis 0.00231 Age Factors 0.00199 Base Sequence 0.00220 Immunohistochemistry 0.00188 Mice 0.00220 Proteins 0.00177 Amino Acid Sequence 0.00220 Reference Values 0.00177 Adolescent 0.00220 Middle Aged 0.00177 Cells, Cultured 0.00220 Reproducibility of Results 0.00177 Molecular Sequence Data 0.00209 Sequence Homology, Amino Acid 0.00166 TOPIC 269 0.00098 TOPIC 270 0.00097 chang 0.42690 process 0.26998 alter 0.16076 event 0.12074 increas 0.04438 involv 0.06287 decreas 0.03879 step 0.05554 observ 0.03551 lead 0.05312 affect 0.03342 occur 0.03377 signific 0.02756 initi 0.03275 occur 0.01875 develop 0.02257 caus 0.01510 kei 0.01868 accompani 0.01326 gener 0.01611 morpholog 0.01270 critic 0.01552 lead 0.01140 requir 0.01342 reflect 0.01109 final 0.01300 declin 0.01006 mechan 0.01248 shift 0.01002 subsequ 0.01153 dramat 0.00967 facilit 0.00969 global 0.00719 place 0.00951 consequ 0.00667 consequ 0.00862 relat 0.00648 undergo 0.00811 examin 0.00545 trigger 0.00807 Aging 0.02170 Animals 0.01869 Humans 0.01376 Humans 0.01430 Time Factors 0.00917 Models, Biological 0.00968 Animals 0.00817 Mice 0.00473 Middle Aged 0.00336 Time Factors 0.00383 Membrane Proteins 0.00291 Membrane Proteins 0.00281 Reverse Transcriptase Polymerase Chain Reaction 0.00280 Molecular Sequence Data 0.00270 Immunohistochemistry 0.00280 Neoplasms 0.00270 Mice 0.00268 Cells, Cultured 0.00259 Adult 0.00246 Models, Genetic 0.00248 Gene Expression 0.00235 Signal Transduction 0.00248 Gene Expression Regulation 0.00224 Reverse Transcriptase Polymerase Chain Reaction 0.00236 Signal Transduction 0.00224 Gene Expression Regulation 0.00225 Proteins 0.00213 Nuclear Proteins 0.00214 Rats 0.00213 Proteins 0.00203 Age Factors 0.00213 Amino Acid Sequence 0.00191 Aged 0.00201 DNA-Binding Proteins 0.00191 Oligonucleotide Array Sequence Analysis 0.00190 DNA 0.00191 Adaptation, Physiological 0.00190 Mutation 0.00191 Base Sequence 0.00179 Cell Division 0.00191 TOPIC 271 0.00097 TOPIC 272 0.00096 requir 0.20658 associ 0.52323 integr 0.05058 studi 0.08521 essenti 0.04293 suggest 0.03114 maintain 0.04259 suicid 0.02860 necessari 0.04197 signific 0.02516 critic 0.03591 find 0.02299 suffici 0.03571 examin 0.02234 mainten 0.03375 independ 0.01874 establish 0.02570 attempt 0.01844 depend 0.02529 observ 0.01499 minim 0.02341 investig 0.01471 elimin 0.01827 includ 0.01399 effici 0.01532 data 0.01231 addit 0.01528 previou 0.01084 lack 0.01353 implic 0.01000 allow 0.01350 associat 0.00922 defin 0.01259 link 0.00890 proper 0.01252 frequent 0.00884 remov 0.01183 strong 0.00863 compet 0.01064 relat 0.00745 Animals 0.00782 Suicide 0.04503 Humans 0.00533 Humans 0.02194 Transcription, Genetic 0.00431 Suicide, Attempted 0.01899 Time Factors 0.00397 Middle Aged 0.00750 Mutation 0.00363 Aged 0.00614 Models, Biological 0.00352 Adult 0.00500 Plasmids 0.00340 Adolescent 0.00478 Gene Deletion 0.00329 Longitudinal Studies 0.00352 Mice, Knockout 0.00283 Risk Factors 0.00341 United States 0.00283 Odds Ratio 0.00341 Kinetics 0.00272 Sex Factors 0.00307 Phenotype 0.00261 Genetic Predisposition to Disease 0.00284 Mice 0.00249 Cohort Studies 0.00273 Transcription Factors 0.00249 Logistic Models 0.00273 Models, Genetic 0.00249 Risk Assessment 0.00262 Amino Acid Sequence 0.00238 Case-Control Studies 0.00262 DNA-Binding Proteins 0.00238 Aged, 80 and over 0.00239 Protein Structure, Tertiary 0.00238 Incidence 0.00227 Gene Expression Regulation 0.00227 Age Factors 0.00227 Recombinant Fusion Proteins 0.00215 Follow-Up Studies 0.00205 TOPIC 273 0.00095 TOPIC 274 0.00095 rate 0.40271 variabl 0.13720 higher 0.04736 differ 0.13152 approxim 0.04012 variat 0.13075 lower 0.02455 distribut 0.10500 kinet 0.02385 heterogen 0.04591 time 0.02245 vari 0.03319 high 0.02227 individu 0.03154 respect 0.02127 homogen 0.02074 compar 0.01885 determin 0.02035 slow 0.01882 rang 0.01731 observ 0.01867 wide 0.01709 averag 0.01782 explain 0.01370 constant 0.01485 influenc 0.01324 rel 0.01378 larg 0.01303 similar 0.01358 account 0.01291 measur 0.01283 consist 0.01279 low 0.01271 consider 0.01268 faster 0.01152 highli 0.01246 declin 0.01125 signific 0.01238 rapid 0.01118 reflect 0.00914 Kinetics 0.06845 Variation (Genetics) 0.10678 Time Factors 0.02201 Humans 0.00775 Humans 0.00507 Polymorphism, Genetic 0.00497 Animals 0.00426 Genetic Heterogeneity 0.00463 Models, Biological 0.00311 Adult 0.00416 Computer Simulation 0.00300 Animals 0.00393 Aged 0.00265 Middle Aged 0.00393 Analysis of Variance 0.00254 Analysis of Variance 0.00393 Adolescent 0.00230 Reproducibility of Results 0.00301 Middle Aged 0.00230 Phenotype 0.00289 Algorithms 0.00230 Aged 0.00278 Age Factors 0.00230 Child 0.00266 Models, Chemical 0.00207 Time Factors 0.00255 Adult 0.00184 Regression Analysis 0.00255 Oxygen 0.00184 Sex Factors 0.00243 Aged, 80 and over 0.00184 Infant 0.00208 Mice 0.00173 Mutation 0.00208 Follow-Up Studies 0.00161 Models, Genetic 0.00197 Treatment Outcome 0.00161 Evolution 0.00197 Prospective Studies 0.00161 Species Specificity 0.00197 TOPIC 275 0.00094 TOPIC 276 0.00094 enhanc 0.24008 involv 0.09540 increas 0.10412 seri 0.04997 endogen 0.04848 correct 0.04956 reduc 0.03582 classic 0.03007 suggest 0.03565 includ 0.02901 attenu 0.03131 present 0.02474 deplet 0.02782 report 0.02253 demonstr 0.02699 multipl 0.02248 exogen 0.02564 frequent 0.02030 contribut 0.02399 repres 0.01904 acceler 0.02371 addit 0.01806 augment 0.02257 possibl 0.01792 result 0.02236 describ 0.01750 level 0.02204 final 0.01690 furthermor 0.01902 investig 0.01598 indic 0.01834 sporad 0.01551 addit 0.01706 larg 0.01522 contrast 0.01585 neuroendocrin 0.01429 markedli 0.01433 find 0.01424 modul 0.01417 identifi 0.01405 Enhancer Elements (Genetics) 0.01197 Pheochromocytoma 0.02814 Animals 0.00686 Hyperparathyroidism 0.02592 Time Factors 0.00605 Adrenal Gland Neoplasms 0.02370 Humans 0.00535 Multiple Endocrine Neoplasia Type 1 0.01343 Cells, Cultured 0.00442 Carcinoid Tumor 0.01133 Cell Line 0.00430 Parathyroid Hormone 0.01016 Mice 0.00419 Succinate Dehydrogenase 0.00969 Rats 0.00395 Receptors, Calcium-Sensing 0.00969 Down-Regulation 0.00372 Humans 0.00922 Immunoblotting 0.00372 Hypercalcemia 0.00887 Up-Regulation 0.00349 Neuroendocrine Tumors 0.00689 Kinetics 0.00337 Paraganglioma 0.00607 Base Sequence 0.00314 Middle Aged 0.00502 Gene Expression 0.00314 Receptor Protein-Tyrosine Kinases 0.00455 Transfection 0.00314 Parathyroid Neoplasms 0.00455 RNA, Messenger 0.00291 Animal Rights 0.00397 Gene Expression Regulation 0.00291 Animal Care Committees 0.00385 Cell Proliferation 0.00267 Proto-Oncogene Proteins c-ret 0.00374 Transcription, Genetic 0.00267 Child 0.00362 Dose-Response Relationship, Drug 0.00256 Laboratory Animal Science 0.00362 TOPIC 277 0.00094 TOPIC 278 0.00094 presenc 0.23063 major 0.13320 absenc 0.11567 studi 0.08770 suggest 0.04836 head 0.08141 observ 0.04273 neck 0.05746 indic 0.04005 pool 0.04581 studi 0.03588 minor 0.04425 gamma 0.02584 includ 0.03828 addit 0.02478 indic 0.03318 peroxisom 0.02368 data 0.03025 data 0.02346 determin 0.02845 demonstr 0.02211 consist 0.02334 ppargamma 0.01750 cyst 0.02115 independ 0.01549 suggest 0.02018 investig 0.01546 find 0.01818 lack 0.01339 investig 0.01724 absent 0.01319 addit 0.01680 reveal 0.01289 observ 0.01522 affect 0.01264 signific 0.01474 confirm 0.01199 examin 0.01408 possibl 0.01118 hnscc 0.01396 PPAR gamma 0.10372 Head and Neck Neoplasms 0.20043 Thiazolidinediones 0.03633 Carcinoma, Squamous Cell 0.01735 Glycosylation End Products, Advanced 0.01090 Head 0.01067 Chromans 0.00762 Neck 0.00399 Humans 0.00703 Animals 0.00363 Peroxisomes 0.00645 Humans 0.00328 PPAR alpha 0.00504 Echinococcosis 0.00293 Adult 0.00434 Time Factors 0.00246 Animals 0.00410 Arachnoid Cysts 0.00246 Time Factors 0.00375 Hydra 0.00246 Prostaglandin D2 0.00340 Child 0.00234 Mice 0.00258 Middle Aged 0.00211 Receptors, Immunologic 0.00258 United States 0.00199 Adolescent 0.00223 Phenotype 0.00188 Ligands 0.00223 Aged, 80 and over 0.00176 Brain 0.00223 Carrier Proteins 0.00176 Alanine 0.00223 Age Factors 0.00176 Child 0.00211 Membrane Proteins 0.00164 Carrier Proteins 0.00211 Echinococcus granulosus 0.00164 Age Factors 0.00211 Adult 0.00152 TOPIC 279 0.00093 TOPIC 280 0.00093 studi 0.38997 extract 0.13028 evalu 0.11205 content 0.11058 assess 0.06377 compon 0.10178 design 0.04707 fraction 0.09841 perform 0.04334 contain 0.04037 aim 0.03210 complement 0.03590 conduct 0.02272 enrich 0.02342 determin 0.01985 total 0.02236 potenti 0.01607 indic 0.02203 preliminari 0.01482 prepar 0.01704 impact 0.01313 composit 0.01669 establish 0.01235 addit 0.01440 investig 0.01220 major 0.01368 need 0.01169 amount 0.01362 object 0.01032 approxim 0.01285 possibl 0.01019 princip 0.01162 consid 0.00985 observ 0.01085 undertaken 0.00985 similar 0.01054 util 0.00958 determin 0.00982 feasibl 0.00945 experi 0.00925 Pilot Projects 0.02821 Plant Extracts 0.08990 Humans 0.00944 Phenols 0.01090 Adult 0.00437 Phytotherapy 0.00533 Adolescent 0.00413 Flavonoids 0.00533 Time Factors 0.00401 Animals 0.00497 Feasibility Studies 0.00366 Vitis 0.00426 Child 0.00342 Fruit 0.00367 Research Design 0.00331 Complement System Proteins 0.00367 Middle Aged 0.00295 Humans 0.00332 Sensitivity and Specificity 0.00295 Hydrogen-Ion Concentration 0.00296 Rh-Hr Blood-Group System 0.00271 Antimutagenic Agents 0.00296 Aged, 80 and over 0.00248 Cell Extracts 0.00261 Follow-Up Studies 0.00236 Antigens, CD55 0.00261 Aged 0.00236 Solubility 0.00249 Risk Assessment 0.00236 Centrifugation, Density Gradient 0.00249 Prospective Studies 0.00224 Wine 0.00249 Evaluation Studies 0.00224 Beer 0.00237 Predictive Value of Tests 0.00212 Dose-Response Relationship, Drug 0.00225 Animals 0.00201 Complement Activation 0.00213 Longitudinal Studies 0.00201 Plants, Medicinal 0.00213 TOPIC 281 0.00092 TOPIC 282 0.00089 respons 0.69252 compar 0.20066 respond 0.06468 higher 0.15824 elicit 0.01635 lower 0.10178 stimuli 0.01495 differ 0.09876 partial 0.01367 versu 0.07924 complet 0.01282 respect 0.05473 follow 0.01205 similar 0.03647 fail 0.01029 greater 0.03533 determin 0.01009 signific 0.03248 defin 0.01003 percentag 0.03137 sustain 0.00989 comparison 0.03019 consist 0.00953 proport 0.02316 stimulu 0.00720 observ 0.01846 appear 0.00640 total 0.01483 intact 0.00431 fewer 0.00808 despit 0.00424 equal 0.00666 predict 0.00400 counterpart 0.00647 non-respond 0.00399 better 0.00562 contrast 0.00396 similarli 0.00486 includ 0.00365 tend 0.00472 Humans 0.01497 Humans 0.01263 Time Factors 0.01033 Middle Aged 0.00650 Animals 0.00748 Analysis of Variance 0.00588 Reverse Transcriptase Polymerase Chain Reaction 0.00344 Adult 0.00539 Adult 0.00321 Time Factors 0.00478 Dose-Response Relationship, Drug 0.00321 Animals 0.00429 Pharmacogenetics 0.00309 Aged 0.00429 Intracellular Signaling Peptides and Proteins 0.00273 Adolescent 0.00270 Treatment Outcome 0.00261 Regression Analysis 0.00270 Biological Markers 0.00261 Retrospective Studies 0.00245 Transcription Factors 0.00249 Reference Values 0.00221 Pregnancy 0.00238 Risk Factors 0.00221 Predictive Value of Tests 0.00238 Aged, 80 and over 0.00196 Mice 0.00226 Data Interpretation, Statistical 0.00196 Mutation 0.00226 Age Factors 0.00196 Models, Biological 0.00226 Infant 0.00184 Drug Resistance 0.00226 Infant, Newborn 0.00184 DNA-Binding Proteins 0.00214 Aging 0.00172 United States 0.00214 DNA 0.00172 RNA, Messenger 0.00202 Mutation 0.00172 TOPIC 283 0.00089 TOPIC 284 0.00089 evid 0.20658 posit 0.36437 provid 0.14777 repeat 0.16099 direct 0.08005 neg 0.15522 link 0.05379 tandem 0.02570 support 0.03180 correl 0.02516 suggest 0.03170 cag 0.01873 demonstr 0.02801 length 0.01670 recent 0.02528 number 0.01352 find 0.02351 respect 0.01333 data 0.02040 indic 0.01205 strong 0.01997 expans 0.01098 known 0.01919 suggest 0.01028 addit 0.01726 short 0.01005 implic 0.01548 fals 0.00936 directli 0.01394 satellit 0.00869 littl 0.01377 presenc 0.00836 evidenc 0.01307 show 0.00764 clear 0.01197 determin 0.00743 independ 0.01184 invers 0.00723 indirect 0.01034 unit 0.00611 Humans 0.01010 Trinucleotide Repeats 0.04261 Animals 0.00727 Repetitive Sequences, Nucleic Acid 0.03014 Models, Biological 0.00481 Tandem Repeat Sequences 0.02755 Polymerase Chain Reaction 0.00456 Trinucleotide Repeat Expansion 0.02038 Time Factors 0.00357 DNA, Satellite 0.00766 Mice 0.00283 Humans 0.00753 Mutation 0.00283 Base Sequence 0.00556 Rats 0.00259 Repetitive Sequences, Amino Acid 0.00482 Cell Line 0.00246 Animals 0.00358 Nuclear Proteins 0.00234 DNA 0.00358 Nerve Tissue Proteins 0.00222 Middle Aged 0.00321 Neoplasms 0.00222 Predictive Value of Tests 0.00296 Adult 0.00209 False Positive Reactions 0.00296 Membrane Proteins 0.00209 Aged 0.00284 Child 0.00209 Polymerase Chain Reaction 0.00259 United States 0.00209 Receptors, Androgen 0.00259 RNA, Messenger 0.00197 Adult 0.00235 Microscopy, Fluorescence 0.00197 Aged, 80 and over 0.00222 Evidence-Based Medicine 0.00197 Risk Assessment 0.00222 Base Sequence 0.00185 Probability 0.00222 TOPIC 285 0.00089 TOPIC 286 0.00088 state 0.17244 condit 0.19875 natur 0.06367 experi 0.12566 transit 0.05113 experiment 0.06396 occur 0.04446 depend 0.05315 unite 0.03120 direct 0.03276 lead 0.02326 physiolog 0.03166 defin 0.02069 possibl 0.03142 rise 0.02048 differ 0.02875 consequ 0.02008 investig 0.02690 repres 0.01986 affect 0.02568 appear 0.01949 influenc 0.02452 gener 0.01829 order 0.02272 like 0.01726 work 0.01272 possibl 0.01542 consid 0.01256 probabl 0.01342 place 0.01224 exist 0.01307 allow 0.01050 give 0.01265 consequ 0.00979 fact 0.01209 indirect 0.00875 despit 0.01202 particular 0.00833 phenomenon 0.01098 hand 0.00790 United States 0.01545 Humans 0.00682 Humans 0.01471 Animals 0.00608 Animals 0.00791 Time Factors 0.00484 Great Britain 0.00396 Analysis of Variance 0.00335 Time Factors 0.00383 Dose-Response Relationship, Drug 0.00285 Oregon 0.00247 Adult 0.00273 Models, Biological 0.00235 Rats 0.00260 History, 20th Century 0.00235 United States 0.00236 Adult 0.00223 Genetic Techniques 0.00236 Prognosis 0.00210 Cells, Cultured 0.00223 Alleles 0.00198 Kinetics 0.00211 Base Sequence 0.00185 Mice 0.00186 Aged 0.00173 Aged 0.00186 RNA, Messenger 0.00173 Adaptation, Physiological 0.00174 Gene Expression Regulation 0.00173 Aging 0.00161 Pregnancy 0.00173 Nerve Tissue Proteins 0.00161 Molecular Sequence Data 0.00161 DNA 0.00161 Infant 0.00161 Reproducibility of Results 0.00161 Sequence Alignment 0.00161 Hydrogen-Ion Concentration 0.00161 Cell Cycle 0.00161 Genetic Screening 0.00149 TOPIC 287 0.00086 TOPIC 288 0.00086 analysi 0.40291 properti 0.10014 reveal 0.17124 potenti 0.09543 analys 0.08846 abil 0.08938 indic 0.05161 modul 0.08124 studi 0.03990 demonstr 0.06368 perform 0.03989 capac 0.04884 data 0.03343 exhibit 0.03261 confirm 0.03135 abl 0.02436 demonstr 0.02027 capabl 0.02381 detail 0.01489 biolog 0.02069 analyz 0.01008 possess 0.01902 find 0.00842 displai 0.01743 furthermor 0.00805 intrins 0.01705 addit 0.00791 addit 0.01659 suggest 0.00745 partial 0.01289 lpa 0.00544 varieti 0.01278 determin 0.00500 similar 0.01249 comprehens 0.00354 uniqu 0.01195 princip 0.00338 function 0.01154 summari 0.00244 natur 0.01131 Humans 0.00989 Animals 0.00877 Gene Expression Profiling 0.00393 Stilbenes 0.00521 Gene Expression 0.00355 Time Factors 0.00470 Lysophospholipids 0.00330 Humans 0.00445 Time Factors 0.00304 Mice 0.00445 Reverse Transcriptase Polymerase Chain Reaction 0.00304 Kinetics 0.00356 Base Sequence 0.00279 Cricetinae 0.00330 Immunohistochemistry 0.00279 DNA Primers 0.00318 Aged 0.00266 Gene Expression Regulation 0.00318 Polymerase Chain Reaction 0.00266 Models, Biological 0.00305 Animals 0.00254 Phenotype 0.00267 Mutation 0.00254 Models, Genetic 0.00267 Sequence Analysis, DNA 0.00254 Aging 0.00241 Aged, 80 and over 0.00241 Electrophoresis, Polyacrylamide Gel 0.00241 Molecular Sequence Data 0.00228 Gene Expression Profiling 0.00229 Models, Biological 0.00228 Variation (Genetics) 0.00229 Sequence Alignment 0.00228 Signal Transduction 0.00229 Membrane Glycoproteins 0.00228 Mutation 0.00203 DNA Mutational Analysis 0.00228 Peptides 0.00203 DNA Primers 0.00216 Tumor Cells, Cultured 0.00191 TOPIC 289 0.00086 TOPIC 290 0.00084 report 0.24815 form 0.30556 studi 0.18825 solubl 0.04491 previou 0.08125 indic 0.02601 intern 0.05571 elong 0.02547 find 0.03745 suggest 0.02356 consist 0.03548 appear 0.02285 includ 0.02981 pure 0.01970 confirm 0.02807 cross-link 0.01823 demonstr 0.02774 report 0.01562 suggest 0.02114 extens 0.01547 addit 0.02066 occur 0.01524 extern 0.01955 highli 0.01383 describ 0.01625 reveal 0.01331 observ 0.01608 character 0.01319 work 0.01449 demonstr 0.01288 earlier 0.01356 known 0.01275 extend 0.01082 presenc 0.01131 complet 0.01039 possibl 0.01115 fail 0.00936 exist 0.01102 recent 0.00715 remain 0.01025 Humans 0.00651 Solubility 0.01982 Animals 0.00383 Red-Cell Aplasia, Pure 0.01773 Adolescent 0.00383 Pseudoxanthoma Elasticum 0.01239 S100 Proteins 0.00370 Humans 0.00991 Adult 0.00357 Erythropoietin, Recombinant 0.00535 Time Factors 0.00268 Cross-Linking Reagents 0.00443 Genes, Reporter 0.00255 Animals 0.00417 DNA, Complementary 0.00242 Time Factors 0.00404 Mice 0.00217 Transglutaminases 0.00404 Reproducibility of Results 0.00217 Models, Biological 0.00378 Child, Preschool 0.00204 Multidrug Resistance-Associated Proteins 0.00313 Cohort Studies 0.00191 Gene Expression 0.00287 Cell Line 0.00191 Membrane Proteins 0.00274 Models, Biological 0.00191 Base Sequence 0.00261 Molecular Sequence Data 0.00179 Adolescent 0.00261 Child 0.00179 DNA 0.00261 Cricetinae 0.00179 Rats 0.00235 Middle Aged 0.00179 Recombinant Proteins 0.00235 Adenosine Deaminase 0.00179 Cutis Laxa 0.00222 DNA Primers 0.00166 Protein Binding 0.00209 TOPIC 291 0.00084 TOPIC 292 0.00083 includ 0.09535 high 0.34131 rang 0.07844 low 0.25190 wide 0.07369 level 0.16156 major 0.05283 densiti 0.06217 varieti 0.05214 higher 0.01776 common 0.04895 lower 0.01628 divers 0.04635 extrem 0.01543 known 0.03495 moder 0.01444 larg 0.03110 rel 0.01420 broad 0.02848 despit 0.01045 spectrum 0.02570 intermedi 0.00947 repres 0.02290 highest 0.00855 caus 0.01798 contrast 0.00737 type 0.01473 remain 0.00538 numer 0.01336 show 0.00488 particular 0.01271 explain 0.00381 littl 0.01239 poor 0.00373 number 0.01165 amount 0.00369 remain 0.00994 reflect 0.00361 certain 0.00979 degre 0.00240 Humans 0.00837 Humans 0.00632 Animals 0.00615 Animals 0.00580 Neoplasms 0.00340 Time Factors 0.00422 Time Factors 0.00288 Sensitivity and Specificity 0.00382 Variation (Genetics) 0.00248 Adult 0.00369 Genetic Predisposition to Disease 0.00222 Adolescent 0.00356 Cell Nucleus 0.00196 Aged 0.00263 Phenotype 0.00196 Risk Assessment 0.00263 Sequence Analysis, DNA 0.00196 Mice 0.00250 Molecular Sequence Data 0.00170 Base Sequence 0.00237 Mice 0.00170 Phenotype 0.00224 Models, Molecular 0.00170 Cell Count 0.00224 Sequence Alignment 0.00170 DNA Primers 0.00211 Reproducibility of Results 0.00170 Sequence Analysis, DNA 0.00211 Drug Design 0.00170 Cell Proliferation 0.00198 DNA Primers 0.00157 Middle Aged 0.00198 Proteins 0.00157 Aged, 80 and over 0.00184 Oligonucleotide Array Sequence Analysis 0.00157 Statistics, Nonparametric 0.00184 DNA 0.00157 Adaptation, Physiological 0.00184 Gene Expression Regulation 0.00157 Rabbits 0.00171 TOPIC 293 0.00083 TOPIC 294 0.00082 data 0.21763 primari 0.27426 support 0.17567 reduc 0.20108 hypothesi 0.06454 reduct 0.13131 set 0.05290 secondari 0.09128 provid 0.02856 compar 0.02938 evid 0.02729 result 0.02412 analys 0.02649 signific 0.01969 consist 0.02385 addit 0.01835 suggest 0.02321 observ 0.01749 base 0.01588 mark 0.01374 propos 0.01479 data 0.01333 hypothes 0.01429 occur 0.01273 previou 0.01408 substanti 0.01227 collect 0.01224 examin 0.01195 larg 0.01164 decreas 0.01108 addit 0.01111 caus 0.00916 exist 0.01083 contrast 0.00820 notion 0.00955 markedli 0.00781 find 0.00943 lead 0.00689 idea 0.00915 indic 0.00663 Humans 0.01175 Humans 0.01561 United States 0.00647 Middle Aged 0.00640 Animals 0.00409 Adult 0.00414 Models, Biological 0.00304 Time Factors 0.00400 Adolescent 0.00264 Animals 0.00320 Data Interpretation, Statistical 0.00264 Mutation 0.00307 Reproducibility of Results 0.00251 DNA Primers 0.00294 Molecular Sequence Data 0.00225 DNA-Binding Proteins 0.00294 Mice 0.00198 Aged, 80 and over 0.00280 Software 0.00198 Down-Regulation 0.00267 Immunohistochemistry 0.00185 Cell Line 0.00267 Sequence Analysis, DNA 0.00185 Treatment Outcome 0.00267 Nerve Growth Factors 0.00185 Cell Adhesion 0.00254 Analysis of Variance 0.00185 Neoplasms, Second Primary 0.00254 DNA Primers 0.00172 Cells, Cultured 0.00227 Gene Expression Regulation 0.00172 Oxidation-Reduction 0.00227 Time Factors 0.00172 Magnetic Resonance Imaging 0.00227 Kinetics 0.00172 Transcription Factors 0.00213 Cluster Analysis 0.00172 Aged 0.00213 Utah 0.00172 Immunohistochemistry 0.00200 TOPIC 295 0.00081 TOPIC 296 0.00081 initi 0.17646 number 0.40102 phase 0.15043 larg 0.11954 second 0.08377 copi 0.06484 follow 0.06537 small 0.05029 subsequ 0.04967 increas 0.02317 observ 0.03885 limit 0.01843 occur 0.03661 approxim 0.01695 indic 0.02175 rel 0.01587 sequenti 0.02045 proport 0.01511 consist 0.01975 singl 0.01470 studi 0.01891 total 0.01365 salmonella 0.01796 includ 0.01330 demonstr 0.01641 possibl 0.01311 complet 0.01252 high 0.01170 tuber 0.01135 larger 0.00932 addit 0.01100 fewer 0.00899 typhimurium 0.01050 numer 0.00877 enter 0.01029 greater 0.00767 serovar 0.00906 low 0.00712 stationari 0.00798 half 0.00644 Tuberous Sclerosis 0.03477 Gene Dosage 0.07418 Salmonella typhimurium 0.03099 Humans 0.00530 Repressor Proteins 0.01186 Time Factors 0.00475 Humans 0.00795 Cell Count 0.00448 Time Factors 0.00714 Animals 0.00353 Tumor Suppressor Proteins 0.00512 Models, Genetic 0.00326 Salmonella 0.00512 DNA 0.00258 Salmonella Infections, Animal 0.00485 Reproducibility of Results 0.00245 Rhabdomyoma 0.00445 Mutation 0.00231 Salmonella enterica 0.00323 Adolescent 0.00217 Animals 0.00283 Mice 0.00204 Neoplasms, Second Primary 0.00283 Aged 0.00204 Heart Neoplasms 0.00270 Proteins 0.00190 Models, Biological 0.00243 Treatment Outcome 0.00190 Adult 0.00216 Neoplasms 0.00190 Mutation 0.00216 Middle Aged 0.00177 Analysis of Variance 0.00202 Gene Expression Regulation 0.00177 Bacterial Proteins 0.00202 Polymerase Chain Reaction 0.00177 Gene Expression Regulation, Bacterial 0.00189 Chemokines, CC 0.00177 Salmonella Infections 0.00189 Cell Line, Tumor 0.00163 TOPIC 297 0.00080 TOPIC 298 0.00080 differ 0.43016 rel 0.11946 type 0.14518 influenc 0.09446 subtyp 0.06710 differ 0.07687 distinct 0.03071 observ 0.06839 specif 0.02041 extent 0.05578 comparison 0.02015 impact 0.05120 characterist 0.01645 determin 0.04015 origin 0.01296 prefer 0.03943 distinguish 0.01263 studi 0.02813 exist 0.01207 compar 0.02384 accord 0.01142 signific 0.02135 relat 0.01110 indic 0.01946 analyz 0.01017 contrast 0.01805 similar 0.01009 color 0.01791 separ 0.00932 littl 0.01632 vari 0.00919 appear 0.01558 defin 0.00902 lesser 0.01487 clear 0.00880 greater 0.01420 predomin 0.00826 strong 0.01381 pattern 0.00803 examin 0.01119 Humans 0.00753 Humans 0.00740 Animals 0.00643 Animals 0.00589 Analysis of Variance 0.00411 Time Factors 0.00534 Genotype 0.00370 Color 0.00370 Adult 0.00329 Adolescent 0.00315 Phenotype 0.00315 Middle Aged 0.00260 Polymerase Chain Reaction 0.00301 Reference Values 0.00247 Sequence Analysis, DNA 0.00301 Dose-Response Relationship, Drug 0.00219 Aged 0.00274 Phenotype 0.00219 Adolescent 0.00246 Base Sequence 0.00205 DNA 0.00246 Neoplasms 0.00205 Reverse Transcriptase Polymerase Chain Reaction 0.00233 Regression Analysis 0.00205 Oligonucleotide Array Sequence Analysis 0.00219 Color Perception 0.00205 Signal Transduction 0.00219 Analysis of Variance 0.00192 Middle Aged 0.00205 Genetic Predisposition to Disease 0.00178 Aged, 80 and over 0.00205 Age Factors 0.00178 Polymorphism, Genetic 0.00205 Linear Models 0.00178 Cell Line 0.00192 Molecular Sequence Data 0.00164 Mutation 0.00192 Proteins 0.00164 Reference Values 0.00192 Infant 0.00164 TOPIC 299 0.00079 TOPIC 300 0.00075 gener 0.31763 tumour 0.25990 specif 0.11014 analys 0.05334 produc 0.09838 studi 0.04295 chimer 0.02452 characteris 0.02796 allow 0.02116 investig 0.02781 demonstr 0.01987 weak 0.02196 replac 0.01978 aim 0.02037 addit 0.01891 malign 0.02006 deriv 0.01503 observ 0.01914 highli 0.01473 potenti 0.01592 potenti 0.01415 centr 0.01461 subsequ 0.01390 frequent 0.01453 abl 0.01347 possibl 0.01415 yield 0.01250 type 0.01296 util 0.01190 relat 0.01293 abil 0.01173 differ 0.01282 chimera 0.01069 aims 0.01247 uniqu 0.01051 high 0.01211 lack 0.00944 signific 0.01202 creat 0.00911 solid 0.01197 Chimera 0.01020 Neoplasms 0.02155 Animals 0.00800 Humans 0.00792 Humans 0.00524 Tumor Markers, Biological 0.00792 Recombinant Fusion Proteins 0.00386 Cell Transformation, Neoplastic 0.00630 Green Fluorescent Proteins 0.00331 Disease Progression 0.00440 Cell Line 0.00290 Adult 0.00366 Rats 0.00248 Prognosis 0.00322 Kinetics 0.00248 Aged 0.00322 DNA, Complementary 0.00248 Neoplasm Proteins 0.00322 Plasmids 0.00248 Child 0.00293 Molecular Sequence Data 0.00234 Time Factors 0.00293 Recombinant Proteins 0.00234 Animals 0.00279 Cell Line, Tumor 0.00221 Transcription Factors 0.00279 Base Sequence 0.00221 In Situ Hybridization 0.00279 Phenotype 0.00221 Aged, 80 and over 0.00279 Middle Aged 0.00221 Adenocarcinoma 0.00279 Time Factors 0.00221 Immunohistochemistry 0.00279 Gene Expression 0.00207 Cell Line, Tumor 0.00264 Isoenzymes 0.00207 Mice 0.00264 DNA 0.00193 Mutation 0.00264